Acute erythema and edematous skin reaction and ectropion following docetaxel in a patient with non-small cell lung cancer

Abstract

Docetaxel can cause skin reactions such as hypersensitivity, edema, and erythrodysesthesia syndrome as well as side effects involving the skin, including alopecia, nail onycholysis, nail pigmentation, photosensitivity, scleroderma, and paresthesia. In this case report, a patient was admitted to the hospital with widespread erythematous and edematous eruption in the head, neck, trunk, and lower and upper extremities, erythema around the eyes, and drooping of the lower eyelids that developed about 2 hours after receiving chemotherapy consisting of docetaxel. Use of the Naranjo Adverse Drug Reaction Probability Scale--a method for estimating the probability of adverse drug reactions--indicated a probable relationship between the skin reaction and docetaxel therapy in this patient. Docetaxel-associated skin reactions that are so extensive and severe as to lead to eye madarosis and ectropion are reported rarely in the literature.

Delayed hypersensitivity reaction related to the use of pegfilgrastim

“…Typically these occur with or soon after drug administration. 15–18 The time course of the reaction in our patient and the fact that the rash did not return when it was withheld from the last cycle points to this rash being due to the pegfilgrastim.…”

“…On literature review most cases describe allergic reactions to docetaxel and cyclophosphamide as Type I hypersensitivity reaction occurring within a day of administration. [13][14][15][16] Additionally these drugs were continued without reaction for cycle 4; no other drugs were withheld other than pegfilgrastim.…”

Madarosis: A marker of many Maladies

“…[106–108] Garibaldi and Adler described a case that developed madarosis following addition of cetuximab,[109] and which resolved following discontinuation of the treatment.…”

Strahlungs-induzierter subakut kutaner Lupus erythematodes oder außergewöhnliche Radiodermatitis?

“…Problematisch bleibt jedoch die fehlende Sicherung der Diagnose mittels Hautbiopsie. Bei einigen der verwendeten Chemotherapeutika wie Paclitaxel [12 -14], Doxetaxel [15] oder Cisplatin [16] sind zwar phototoxische Reaktionen beschrieben, aber ungewöhnlich. Paclitaxel wurde auch mit der Induktion eines SCLE in Verbindung gebracht [17,18], ist aber ebenfalls sehr selten, sodass eine phototoxische oder medikamentöse [18,19]…”