Acute ethanol-related nervous system injuries

Vyshka, Gentian; Shaqiri, Tefta; Cakani, Bujar; Distafa, Artan

doi:10.4103/2221-6189.250372

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…14 Alcohol intake may affect one's adherence to treatment, they may forget to take their medication or prefer not to buy medicine in preference for alcohol, which may cause increased seizure experiences. 19 We found that frequent alcohol intake did not have a significant effect on the control of seizures. On the contrary, many other studies show that alcohol causes an increased risk of epileptic seizures and that it is a predictor of uncontrolled seizures.…”

Section: Discussionmentioning

confidence: 59%

Correlates of Seizure Control Among Patients with Epilepsy at Two Referral Hospitals in Zambia

Mwansa

Daka

Mulenga

et al. 2020

IJTMRPH

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Background: Epilepsy is a neurological condition that has proven to be a major public health challenge worldwide, including Zambia. Despite the availability of many treatment alternatives, people with epilepsy still experience seizures. There is paucity of information on the control of seizures and associated factors in Zambia. Methods: A cross sectional study was conducted among epileptic patients at Kitwe and Ndola Teaching Hospitals, two referral hospitals in Northern Zambia, from September 2 to September 23, 2019. We performed a multivariate logistic regression analysis to identify independent predictors of seizure control. Adjusted odds ratios and their 95% confidence intervals are reported. Results: A total of 220 epileptic patients were enrolled in the study. Of these, 23.6% had controlled seizures while 76.4% had uncontrolled seizures. Occupation (p value=0.018), level of education (p value<0.001), clinic attendance (p value<0.001), drug adherence (p value<0.001), belief about drugs (p value=0.006) and having friends (p value=0.025) were significantly associated with seizure control. A higher level of education (AOR:0.243, CI:0.080-0.738), regular clinic attendance (AOR:8.578, CI:3.327-22.112) and age at first seizure of 7-12 years (AOR: 1.035, CI:0.240-4.454) were predictors of controlled seizures. Conclusions and Implications for Translation: Our study showed that there was a low prevalence of controlled seizures among the study population. Key words: • Seizure • Control • Epilepsy • Zambia • Healthcare Copyright © 2020 Mwansa et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.

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Section: Discussionmentioning

confidence: 59%

Correlates of Seizure Control Among Patients with Epilepsy at Two Referral Hospitals in Zambia

Mwansa

Daka

Mulenga

et al. 2020

IJTMRPH

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“…3 of 4 [15]. In addition, Jellinek typology had strong psychological backgrounds and the everyday clinical practice might see overlapping of the conditions [14,16].…”

Section: Disorders Of An Acute Naturementioning

confidence: 99%

Gastrointestinal Injuries Following the Acute and Chronic Alcohol Abuse: An Update

Karemani

Basha

Vyshka

2022

WJCMR

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The deleterious health effects of ethanol abuse are widely known and a diversity of medical conditions appear with excessive consumption. Acute and chronic abuse have different clinical characteristics, although severe intoxications are rare among alcoholics of a long career, where the systemic complications will dominate the symptomatology. While the medical focus acutely will mostly stay on the nervous and circulatory effects, gastrointestinal complications that will come up chronically (liver, pancreas, bowel dysfunction) need proper consideration. Ethanol will affect gastrointestinal functionality through a triple action, directly on the epithelial cell and the secretory activity, by altering the motility and in the long-term scope, through promoting carcinogenesis. Medical teams dealing with acute and chronic ethanol intoxication or abuse must be aware of the multiple effects it shows, and perform a prompt diagnosis as well as appropriate intervention.

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“…However, the inability to modify drinking action which has always culminated into chronic consumption is a problem of public health concern. 6 Reports have shown that an estimated 1.2 million people are killed in road traffic crashes each year and up to 50 million injured worldwide. 7 Considering the lifestyle of some community drivers in Nigeria and some other part of Africa who drinks Alcohol/alcohol contained solution before embarking on their daily routine, followed by acetaminophen after a long day at work (probably to relieve their pain).…”

Section: Introductionmentioning

confidence: 99%

Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen

Adekeye

Fafure

2022

Hum Exp Toxicol

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Ethanol exposures have been reported to disrupt the development of the retina and optic nerve which can be considered as part of underlying mechanisms of visual pathway impairments. This study aims to investigate the cellular integrity of the retina and the expression of melatonin receptor (MTNR1A) in the retina when assaulted chronically and simultaneously by ethanol and acetaminophen. Animals were randomly grouped into five groups. Control (normal saline), Alcohol group (25% alcohol in 2% sucrose solution), Acetaminophen group, (100 mg/kg BW for 14 days), Acetaminophen + Alcohol group (25% alcohol in 2% sucrose solution + 100 mg/kg BW of paracetamol). Withdrawal group (25% alcohol in 2% sucrose solution + 100 mg/kg BW of paracetamol). The body weight and rectal temperature of the animals were taking every 2 days and a post mortem study was conducted by quantitatively assessing the markers of oxidative stress. Melatonin level was quantified in the retina tissue and Immunohistochemistry was done via MTNR1A to study the expression of melatonin receptor type 1A in the retina. These results demonstrate that alcohol and acetaminophen significantly reduced the activity of retina rat melatonin (MTNR1A) levels, lowers the SOD and MDA activity. Expression of MTNR1A was reduced in the ganglionic cell layer of Alcohol and acetaminophen group as compared to the control and withdrawal group. It can be inferred that chronic simultaneous intake/consumption of alcohol and acetaminophen altered the melatonin level in the retina and this may implicate the circadian clock and melatonin in Wistar rat visual system.

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Acute ethanol-related nervous system injuries

Cited by 3 publications

References 21 publications

Correlates of Seizure Control Among Patients with Epilepsy at Two Referral Hospitals in Zambia

Correlates of Seizure Control Among Patients with Epilepsy at Two Referral Hospitals in Zambia

Gastrointestinal Injuries Following the Acute and Chronic Alcohol Abuse: An Update

Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen

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