Acute exacerbation of idiopathic pulmonary fibrosis

Dallari, Rossano; Foglia, M; Paci, Massimiliano; Cavazza, Alberto

doi:10.1183/09031936.04.00004404

Cited by 20 publications

(17 citation statements)

References 5 publications

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“…(4-7, 19-21, 23). Patients who died shortly after the onset of AE showed an acute phase of DAD, whereas those who survived the initial insult of AE but died of repeated AE afterward showed an organized phase of DAD (19)(20)(21)23 T a b l e 2 . P r o g n o s i s a f t e r Ac u t e E x a c e r b a t i o n …”

Section: Pao2/fio2mentioning

confidence: 99%

“…Patients with IPF may also suffer from acute respiratory deterioration related to complications with a known cause such as pneumonia, pneumothorax, and pulmonary embolism (1)(2)(3)(4)(5)(6)(7). However, a subset of IPF patients would experience an accelerated deterioration of the illness in the absence of any identifiable precipitating cause, namely, AE, which clinically resembles the acute respiratory distress syndrome (2)(3)(4)(5)(6)(7)(19)(20)(21)(22)(23)(24) (3-6, 17, 18). Eventually, ground glass scores were significantly increased in a similar fashion after AE in both the CsA-treated and the non-CsA-treated groups.…”

Section: Ipf Is a Slowly But Relentlessly Progressing Disease (1-7)mentioning

confidence: 99%

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Cyclosporin A in the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

et al. 2010

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Section: Pao2/fio2mentioning

confidence: 99%

Section: Ipf Is a Slowly But Relentlessly Progressing Disease (1-7)mentioning

confidence: 99%

Cyclosporin A in the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

et al. 2010

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“…Since idiopathic pulmonary fibrosis (IPF) is often associated with lung cancer, the indications for surgery need to be assessed by giving careful consideration to the pulmonary function and the risk of acute AE after the sur-cent (7,17,18). The prognosis of AE of IPF/UIP during the postoperative period is extremely poor, and the mortality is reported to be nearly 70-100 percent (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20); therefore, extreme care is required before surgery is performed in IIP patients.…”

Section: Introductionmentioning

confidence: 99%

Acute Exacerbation of Idiopathic Interstitial Pneumonia Following Lung Surgery in 3 of 68 Consecutive Patients: A Retrospective Study

et al. 2011

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Background Acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) is occasionally observed after lung surgery. However, the risk of lung surgery in patients with IIPs is not yet clearly known. Subjects and MethodsWe conducted a retrospective study of consecutive patients who underwent lung surgery for cancer or for the diagnosis of interstitial pneumonia (IP) between 2000 and 2006. Patients who developed AE following the lung operation were assessed. Results The data of 68 consecutive patients (males: 56, females: 12) with IP who underwent lung surgery were analyzed. The lung surgery included lobectomy for lung cancer in 48 patients [idiopathic pulmonary fibrosis (IPF) 31, non-IPF 17], and lung biopsy in 20 patients [IPF 8, non-specific interstitial pneumonia (NSIP) 8, unclassified 4]. Three patients with IPF (4.4% in total) developed AE after the operation (2 lobectomy, 1 biopsy). The triggers of AE were considered to be prolonged ventilation at a large tidal volume with oxygen supplementation at a high concentration. At the time of the AE, the extent of parenchymal involvement on the HRCT images was greater on the non-operated side. All three patients died of respiratory failure 12 to 82 days after the onset of AE despite corticosteroid therapy. Conclusion It is essential to be aware of the risk of AE of IPF following lung operation. Intraoperative respiratory management, such as oxygen supplementation at a high concentration and/or prolonged mechanical ventilation are likely possible etiologic factors.

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“…In some patients, acute exacerbation of idiopathic interstitial pneumonia may comprise organising pneumonia at lung biopsy [421]. Superimposed organising pneumonia was found on explant specimens from a patient with UIP who underwent lung transplantation [422].…”

Section: Severe And/or Overlapping Copmentioning

confidence: 99%

Cryptogenic organising pneumonia

Jf¹

2006

Eur Respir J

485

466

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Organising pneumonia is defined histopathologically by intra-alveolar buds of granulation tissue, consisting of intermixed myofibroblasts and connective tissue. Although nonspecific, this histopathological pattern, together with characteristic clinical and imaging features, defines cryptogenic organising pneumonia when no cause or peculiar underlying context is found. Rapid clinical and imaging improvement is obtained with corticosteroid treatment, but relapses are common after stopping treatment.

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Acute exacerbation of idiopathic pulmonary fibrosis

Cited by 20 publications

References 5 publications

Cyclosporin A in the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Cyclosporin A in the Treatment of Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Acute Exacerbation of Idiopathic Interstitial Pneumonia Following Lung Surgery in 3 of 68 Consecutive Patients: A Retrospective Study

Cryptogenic organising pneumonia

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