Acute exacerbations after decades of non-active chronic multiple sclerosis

Late activity rebound in non-active multiple sclerosis: A rare event

“…We read with interest the letter by Haupts et al, 1 who reported two women, aged 61 and 67 years, with progressive, non-active multiple sclerosis (respectively, for 3 decades and 13 years) who suddenly presented acute exacerbations with concomitant gadolinium-enhancing T1 lesions. If the second patient had recent withdrawal of disease modifying therapies (DMD), no specific trigger was identified in the former raising the opened question of DMD cessation in the context of a stable MS. We recently performed a study to address rebound in MS patients aged ≥50 years with a previous long-term stable disease.…”