Acute Exacerbations of Chronic Obstructive Pulmonary Disease

Weiden, Michael D.; Horowitz, Harold W.

doi:10.1016/b978-1-4557-4801-3.00067-9

Cited by 1 publication

(1 citation statement)

References 201 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These latter two are associated with more severe cases of AB with long periods of incubation. Although bacterial species are rarely associated with AB, there is wide evidence of their key role in the pathogenesis of acute exacerbations of chronic bronchitis (AECB), a different clinical syndrome caused by multiple factors such as environmental exposure, infections, inflammation, and genetic predisposition [34]. S. pneumoniae, H. influenzae, and M. catarrhalis represent the main colonizing bacteria of the lower airways in AECB, with local findings of P. aeruginosa, Stenotrophomonas maltophilia, and Enterobacteriaceae in patients with a high degree of functional pulmonary impairment [34].…”

Section: Acute Bronchitis (Ab)mentioning

confidence: 99%

Respiratory Tract Infections and Laboratory Diagnostic Methods: A Review with A Focus on Syndromic Panel-Based Assays

et al. 2022

View full text Add to dashboard Cite

Respiratory tract infections (RTIs) are the focus of developments in public health, given their widespread distribution and the high morbidity and mortality rates reported worldwide. The clinical spectrum ranges from asymptomatic or mild infection to severe or fatal disease. Rapidity is required in diagnostics to provide adequate and prompt management of patients. The current algorithm for the laboratory diagnosis of RTIs relies on multiple approaches including gold-standard conventional methods, among which the traditional culture is the most used, and innovative ones such as molecular methods, mostly used to detect viruses and atypical bacteria. The implementation of molecular methods with syndromic panels has the potential to be a powerful decision-making tool for patient management despite requiring appropriate use of the test in different patient populations. Their use radically reduces time-to-results and increases the detection of clinically relevant pathogens compared to conventional methods. Moreover, if implemented wisely and interpreted cautiously, syndromic panels can improve antimicrobial use and patient outcomes, and optimize laboratory workflow. In this review, a narrative overview of the main etiological, clinical, and epidemiological features of RTI is reported, focusing on the laboratory diagnosis and the potentialities of syndromic panels.

show abstract

Section: Acute Bronchitis (Ab)mentioning

confidence: 99%