Acute exposure of laboratory mice to manganese oxide

Adkins, Bernard; Luginbuhl, Geraldine H.; Gardner, Donald E.

doi:10.1080/15298668091425130

Cited by 28 publications

(12 citation statements)

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“…Following a 2-h inhalation, mean initial lung deposition was 21.7 ± 2.2 µg Mn/g lung weight, comparable to our highest level for Mn 3 O 4 of 22.8 ± 6.5 µg/g lung weight. Within 24 h, Adkins et al (1980) found that lung levels decreased to 2.98 ± 0.2 µg/g lung weight (not significantly different from control levels). Lung levels 24 h postinstillation in our study were 0.7 ± 0.5 µg/g lung weight (not significantly different from control levels).…”

Section: Manganese Pulmonary Clearance 949mentioning

confidence: 75%

“…In an inhalation study of Mn 3 O 4 by Adkins et al (1980), within 24 h after a 2-h exposure to 1.8 mg/m 3 of Mn 3 O 4 in mice, approximately 14% of inhaled Mn remained in the lung. Following a 2-h inhalation, mean initial lung deposition was 21.7 ± 2.2 µg Mn/g lung weight, comparable to our highest level for Mn 3 O 4 of 22.8 ± 6.5 µg/g lung weight.…”

Section: Manganese Pulmonary Clearance 949mentioning

confidence: 99%

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Pulmonary Clearance of Manganese Phosphate, Manganese Sulfate, and Manganese Tetraoxide by Cd Rats Following Intratracheal Instillation

Vitarella

2000

Inhalation Toxicology

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Manganese (Mn) is ubiquitous in ambient air due to both industrial and crustal sources. It is also a component of the octane-enhancing fuel additive methylcyclopentadienyl manganese tricarbonyl (MMT). The combustion of MMT by the automobile engine results in the formation of Mn particulates including phosphate, sulfate, and oxide forms. The objectives of this study were to determine the contribution of particle dissolution on pulmonary clearance rates of Mn sulfate (MnSO(4)), Mn phosphate, and Mn tetraoxide (Mn(3)O(4)) in CD rats following an intratracheal instillation exposure. In addition, brain (striatal) Mn concentrations were evaluated following exposure. Adult CD rats were intratracheally instilled with 0, 0.04, 0.08, or 0.16 microg Mn/g of either MnSO(4), Mn phosphate, or Mn(3)O(4). Rats were euthanized at 0, 1, 3, or 14 days after instillation. Lung and striatal Mn concentrations were measured by neutron activation analysis. Pulmonary clearance following single intratracheal instillation of MnSO(4), Mn phosphate, or Mn(3)O(4) was similar for each of the three compounds at each of the three doses used. All pulmonary clearance half-times were less than 0.5 day. At the concentrations used, striatal Mn levels were unaffected, and lung pathology was unremarkable. The dissolution rate constant of the Mn particles was determined in vitro using lung simulant fluids. The solubility of the Mn compounds was in general 20 to 40 times greater in Hatch artificial lung lining fluid than in Gamble lung simulant fluid. The dissolution rate constant of the water-soluble MnSO(4) particles in Hatch artificial lung fluid containing protein was 7.5 x 10(-4) g (Mn)/cm(2)/day, which was 54 times that of relatively water-insoluble Mn phosphate and 3600 times that of Mn(3)O(4). The dissolution rate constants for these compounds were sevenfold slower in Gamble lung fluid simulant. For both solutions, the time for half the material to go into solution differed only by factors of 1/83 to 1/17 to 1 for MnSO(4), Mn phosphate, and Mn(3)O(4), respectively, consistent with measured differences in size distribution, specific surface, and dissolution rate constant. These data suggest that dissolution mechanisms only played a role in the pulmonary clearance of MnSO(4), while nonabsorptive (e.g., mechanical transport) mechanisms predominate for the less soluble phosphate and oxide forms of Mn.

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Section: Manganese Pulmonary Clearance 949mentioning

confidence: 75%

Section: Manganese Pulmonary Clearance 949mentioning

confidence: 99%

Pulmonary Clearance of Manganese Phosphate, Manganese Sulfate, and Manganese Tetraoxide by Cd Rats Following Intratracheal Instillation

Vitarella

2000

Inhalation Toxicology

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“…[26] Adkins et al . [27] studied an acute inhalation exposure of laboratory mice to respirable Mn3O4 aerosols and found that a systemic distribution of the manganese was observed in various tissues following exposure. Another present concern is the use of the gasoline additive methylcyclopentadienyl manganese tricarbonyl, which is documented for the generation of air manganese and can be the future problem.…”

Section: Manganese Intoxicationmentioning

confidence: 99%

Minor heavy metal: A review on occupational and environmental intoxication

Wiwanitkit

2008

Indian J Occup Environ Med

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Heavy metal is widely used in industries and presents as a problematic environmental pollution. Some heavy metals, especially lead and mercury, are well described for their occupational and environmental intoxication whereas the other minor heavy metals are less concerned. In this article, the author will present the details of occupational and environmental minor heavy metal intoxication. This review focuses mainly on aluminum, tin, copper, manganese, chromium, cadmium and nickel.

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“…Nach einer zweistündigen Inhalation von Mn 3 O 4 -Aerosol (1,4 Vm, 1798 mg/m 3 ) werden nach 4; 6 und 24 Stunden noch 47; 27 und 14% im Lungengewebe von weiblichen Mäusen gefunden [4]. Im Konzentrationsbereich von 0�2,9 mg Mn/m 3 besteht unter sonst identischen Versuchsbedingungen bei Mäusen, die unmittelbar nach der zweistündigen Exposition getötet wurden, eine lineare Beziehung zwischen der Mangan-Aerosolkonzentration in der Einatmungsluft und dem Mangangehalt/g getrockneter Lunge [4]. …”

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“…In einer weiteren Inhalationsstudie mit Mäusen (2 h, 1837 mg/mn/m 3 ) wurde die Gewebeverteilung 0; 24 und 48 Stunden nach der Inhalation gemessen [4]. In der Lunge finden sich zu diesen Zeitpunkten 21,7; 2,98 und 2,69 Vg Mn/g Trockengewebe.…”

unclassified

Trimangantetroxid (Rauch, Staub) [MAK Value Documentation in German language, 1981]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 8. Lieferung, Ausgabe 1981 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Resorption und Verteilung Erfahrungen beim Menschen Tierexperimentelle Befunde Akute Toxizität Begründung des MAK‐Wertes

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Acute exposure of laboratory mice to manganese oxide

Cited by 28 publications

References 0 publications

Pulmonary Clearance of Manganese Phosphate, Manganese Sulfate, and Manganese Tetraoxide by Cd Rats Following Intratracheal Instillation

Pulmonary Clearance of Manganese Phosphate, Manganese Sulfate, and Manganese Tetraoxide by Cd Rats Following Intratracheal Instillation

Minor heavy metal: A review on occupational and environmental intoxication

Trimangantetroxid (Rauch, Staub) [MAK Value Documentation in German language, 1981]

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