Acute exposure to a 50Hz magnetic field impairs consolidation of spatial memory in rats

Jadidi, Majid; Firoozabadi, Seyed Mohammad; Rashidy-Pour, Ali; Sajadi, Ahmad Ali; Sadeghi, Hassan; Taherian, Aliakbar

doi:10.1016/j.nlm.2007.07.010

Cited by 62 publications

(58 citation statements)

References 23 publications

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“…Previous studies suggest that static and time-varying electric and MFs exposure caused oxidative DNA damage (Ivancsits et al 2003;Yokus et al 2005), increased plasma, liver, lung and kidney TBARS and SOD levels (Harakawa et al 2005;Guler (Jelenkovic et al 2005;Di Loreto et al 2009) altered cell proliferation , cortical serotonergic neurotransmission (Janac et al 2009) and memory impair (Jadidi et al 2007) in various biological organisms. However, the present study differed from earlier investigations in certain regard, as the present investigation was conducted at much lower magnetic intensities (50 and 100 µT) as compared to the other studies, which were conducted at higher intensities (0.1 to 2 mT).…”

Section: Discussionmentioning

confidence: 99%

“…A variety of central nervous system disorders, such as nervousness, anxiety, sleep disturbances and stress have been reported to occur in human population when exposed to magnetic field (Akerstedt et al 1998;Jadidi et al 2007;Funk et al 2009), which has been attracting increased public interest. Previous epidemiological surveys conducted on human exposure to extremely low frequency (ELF) electromagnetic fields (EMF) have implicated that ELF-EMF causes several health disorders in humans, such as various types of brain cancers, depression and suicide, neurodegenerative, cardiovascular and reproductive diseases (Central Power Research Institute Report 2000;Ahlbom et al 2001;World Health Organization Report, 2007;Schuz and Ahlbom 2008;Kheifets et al 2009).…”

Section: Introductionmentioning

confidence: 99%

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Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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Abstract. The present investigation was conducted to understand the influence of long-term exposure of rats to extremely low frequency magnetic fields (ELF-MF), focusing on oxidative stress (OS) on different regions of rat's brain. Male Wistar rats (21-day-old) were exposed to ELF-MF (50 Hz; 50 and 100 µT) for 90 days continuously; hippocampal, cerebellar and cortical regions from rats were analyzed for (i) reactive oxygen species (ROS), (ii) metabolites indicative of OS and (iii) antioxidant enzymes. In comparison to control group rats, the rats that were continuously exposed to ELF-MF caused OS and altered glutathione (GSH/GSSG) levels in dose-dependent manner in all the regions of the brain. Accumulation of ROS, lipid peroxidation end products and activity of superoxide dismutase in different regions was in the descending order of cerebellum > hippocampus > cortex. Decrement in GSH/GSSG levels and increment in glutathione peroxidase activity were in the descending order of hippocampus > cerebellum > cortex. The continuous exposure to ELF-MF caused OS in all the examined regions of brain more significantly at 100 µT than at 50 µT. Varied influences observed in different regions of the brain, as documented in this study, may contribute to altered metabolic patterns in its related regions of the central nervous system, leading to aberrant neuronal functions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Extremely low frequency magnetic fields induce oxidative stress in rat brain

Pk¹,

Rajendra²,

Devendranath³

et al. 2014

gpb

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“…Jadidi et al (2007) provided evidence that exposure to an 8 mT, 50 Hz magnetic field for 20 min impaired the consolidation of spatial memory using a water maze but not the retrieval of learned information. No effect was found with a 2 mT magnetic field (Jadidi et al, 2007). McKay and Persinger (2000) also found that 60 min exposure to a 200-500 nT ELF before the training phase impaired spatial memory in the radial maze, whereas exposure before the testing phase decreased the response times of rats in this task.…”

Section: Figurementioning

confidence: 98%

Effects of single, brief exposure to an 8 mT electromagnetic field on avoidance learning in male and female mice.

Foroozandeh¹,

Ahadi²,

Askari³

et al. 2011

Psychology & Neuroscience

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The present study investigated the effect of extremely low frequency (8 mT, 50 Hz) electromagnetic fields (ELF-EMF) on avoidance learning in mice and compared the effect of an ELF-EMF in adult male and female mice. Learning was evaluated using a passive avoidance learning procedure in a standard wooden box, in which, despite their instinctive tendencies, mice learn to stay on a small platform to avoidant an electric shock. Before each learning session, the animals were exposed to an 8 mT, 50 Hz ELF created by a round coil. Immediately after 60 min exposure to the ELF-EMF, the mice were subjected to avoidance learning. The animals in the sham-exposed control group were placed in the coil for 60 min but were not exposed to the EMF and were subjected to the same behavioral procedures as the experimental group. The comparison of learned behaviors in the experimental and control groups showed that exposure to an 8 mT, 50 Hz ELF for 60 min significantly affected passive avoidance learning in both male (p < .023) and female (p < .015) mice.

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“…Finally, these changes induce neurodegeneration in the brain, so ELF-EMF is regarded as a useful tool to model neuropathology. Some studies have suggested that induced by ELF-EMF exposure at 8 mT for a short time can impair consolidation of spatial memory [6]. Furthermore, studies also found that exposure to 2 mT magnetic fields for 60 min significantly decreased cholinergic activities of hippocampus [7].…”

Section: Introductionmentioning

confidence: 96%