Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model

Mensing, Thomas; Marek, W.; Raulf‐Heimsoth, Monika; Baur, Xaver

doi:10.1183/09031936.98.12061371

Cited by 24 publications

(18 citation statements)

References 20 publications

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“…15 We found a mean persulphate exposure during mixing and application 10-700 times lower (0.015-0.49 mg/m 3 ). The estimated exposure during the mixing periods was 35-250 times lower (0.04-0.15 mg/m 3 ).…”

Section: Discussionmentioning

confidence: 62%

Incidence of asthma in female Swedish hairdressers

Albin

2002

Occup Environ Med

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Objective: To investigate the risk of asthma in hairdressers. Methods: The incidence of asthma was retrospectively estimated in a Swedish nationwide study including all female hairdressers certified from vocational schools from 1970 to 1995, and a stratified sample of women from the general population were referents. A postal questionnaire included questions on respiratory tract symptoms, atopy, smoking, working periods as a hairdresser, and number of specific hair treatments performed/week. Reported exposures were validated by occupational hygienists. Rate ratios of incidence (IRRs) of asthma were estimated by Poisson regression, adjusted for calendar year of observation, hay fever, smoking, and region of domicile. Results: The crude incidences of asthma/1000 person-years were: 3.9 during active years as a hairdresser, 2.8 among the hairdressers when not working in the profession, and 3.1 among the referents. The corresponding IRR for being an active hairdresser compared with the referents was 1.3 (95% confidence interval (95% CI) 1.0 to 1.6). Moderate effects on risk of asthma were found both from hairdressing work (IRR=1.6 (1.1 to 2.2) among never-smokers) and from smoking (IRR=1.6 (1.2 to 2.2) among referents). However, the combined effect from hairdressing work and smoking (IRR=1.5 (1.0 to 2.1)) was less than expected (p=0.02). No effect modification by respiratory atopy was found. The hairdressers most often performing hair bleaching treatments (IRR=1.5 (0.7 to 3.0)) or using hair spray (IRR=1.4 (0.8 to 2.4)) had, compared with the most infrequent users, a slightly, but not significantly higher incidence of asthma. Exposure to persulphates in hair bleach was estimated to be 0.04-0.15 mg/m 3 during mixing of the powder. Reported average number of bleaching treatments agreed well with those performed according to a diary. Conclusions: Active hairdressing work was associated with a moderately increased incidence of asthma among lifelong non-smokers. The results are moderately supportive, but not conclusive, of associations between asthma and exposure to hair bleach or hair spray.

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Section: Discussionmentioning

confidence: 62%

Incidence of asthma in female Swedish hairdressers

Albin

2002

Occup Environ Med

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“…The proposed modified electrode showed stable and reproducible electrochemical behavior at a wide pH range (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The proposed modified electrode showed stable and reproducible electrochemical behavior at a wide pH range (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 92%

“…Cyclic voltammograms of the GC/RuOx/CB electrode at various pH values (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) were recorded ( Figure 6) to investigate the effect of pH on the redox response of the modified electrodes. As presented in the inset of Figure 6, the formal potential of the redox couple was pH dependent.…”

Section: Stability and Ph Dependence Of The Modified Electrodementioning

confidence: 99%

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Electrochemical Detection of Persulfate at the Modified Glassy Carbon Electrode with Nanocomposite Containing Nano‐Ruthenium Oxide/Thionine and Nano‐Ruthenium Oxide/Celestine Blue

Roushani

Karami

2014

Electroanalysis

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The present study describes the fabrication of a sensitive amperometric sensor for the determination of persulfate. The immobilization surface was prepared by modifying a glassy carbon (GC) electrode with a nanocomposite containing ruthenium oxide (RuOx) nanoparticles and thionine (TH) or celestin blue (CB). The modified electrodes indicated excellent electrocatalytic activity toward persulfate reduction at a potential of +0.1 V. The proposed sensor showed detection limits of 1.46 µM for the GC/RuOx/TH modified electrode and 2.64 µM for the GC/RuOx/CB modified electrode. The sensitivities were obtained as 3 nA µM−1 at a concentration range of 10 µM to 11 mM for the GC/RuOx/TH modified electrode and 1 nA µM−1 at a concentration range of 10 µM to 6 mM for the GC/RuOx/CB modified electrodes.

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“…Mast cells are thought to be involved in the pathogenesis of persulphate-induced asthma by releasing a number of inflammatory mediators, including histamine, arachidonic acid derivatives, biogenic amines, chemoattractants, cytokines, growth factors and neuropeptides [13,33]. Direct irritation and damage of the airway mucosa is also thought to play a role [34,35]. …”

Section: Discussionmentioning

confidence: 99%

Inhaled Ammonium Persulphate Inhibits Non-Adrenergic, Non-Cholinergic Relaxations in the Guinea Pig Isolated Trachea

et al. 2009

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Background: Persulphates can act both as irritants and sensitizers in inducing occupational asthma. A dysfunction of nervous control regulating the airway tone has been hypothesized as a mechanism underlying bronchoconstriction in asthma. Objectives: It was the aim of this study to investigate whether inhaled ammonium persulphate affects the non-adrenergic, non-cholinergic (NANC) inhibitory innervation, the cholinergic nerve-mediated contraction or the muscular response to the spasmogens, carbachol or histamine, in the guinea pig epithelium-free, isolated trachea. Methods: Male guinea pigs inhaled aerosols containing ammonium persulphate (10 mg/m³ for 30 min for 5 days during 3 weeks). Control animals inhaled saline aerosol. NANC relaxations to electrical field stimulation at 3 Hz were evaluated in whole tracheal segments as intraluminal pressure changes. Drugs inactivating peptide transmission, nitric oxide synthase, carbon monoxide production by haem oxygenase-2 and soluble guanylyl cyclase were used to assess the involvement of various inhibitory neurotransmitters. Carbachol and histamine cumulative concentration-response curves were obtained. Results: In both groups, nitric oxide and carbon monoxide participated to the same extent as inhibitory neurotransmitters. In exposed animals, the tracheal NANC relaxations were reduced to 45.9 ± 12.1% (p < 0.01). The cholinergic nerve-mediated contractions to electrical field stimulation and the muscular response to histamine were not modified by ammonium persulphate exposure. The muscular response to carbachol was unaffected up to 1 µM. Conversely, the response to the maximal concentration of carbachol (3 µM) was increased (p < 0.01). Conclusion: Ammonium persulphate inhalation at high concentrations impairs the nervous NANC inhibitory control in the guinea pig airways. This may represent a novel mechanism contributing to persulphate-induced asthma.

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Acute exposure to hair bleach causes airway hyperresponsiveness in a rabbit model

Cited by 24 publications

References 20 publications

Incidence of asthma in female Swedish hairdressers

Incidence of asthma in female Swedish hairdressers

Electrochemical Detection of Persulfate at the Modified Glassy Carbon Electrode with Nanocomposite Containing Nano‐Ruthenium Oxide/Thionine and Nano‐Ruthenium Oxide/Celestine Blue

Inhaled Ammonium Persulphate Inhibits Non-Adrenergic, Non-Cholinergic Relaxations in the Guinea Pig Isolated Trachea

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