Acute exposure to paraquat affects the phenotypic differentiation of substantia nigra microglia in rats

Zhang, Wendi; Fan, Xiaobei; Fan, Z.; Wu, Bailin; Wang, Mengchao; Duan, Wanyu; Song, Bo

doi:10.1007/s11356-021-17262-3

Cited by 2 publications

(2 citation statements)

References 35 publications

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“…On the contrary, M2 microglia can remove dead neuron debris and degenerate synapses through immune phagocytosis, secrete anti-inflammatory cytokines, and protect the central nervous system (Perry et al 2010 ). During inflammatory responses, excessive or long-term activation of microglia leads to neuronal death and increases the release of pro-inflammatory cytokines (Rodriguez-Gomez et al 2020 ; Zhang et al 2021b ).…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression

Yao

Liu

Tang

et al. 2022

Environ Sci Pollut Res

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Microglia-mediated neuroinflammation plays a vital role in the pathophysiological processes of multiple neurodegenerative diseases. Lipopolysaccharide (LPS) is an environmental poison that can induce inflammatory microglial activation. Matrix metalloproteinases (MMPs) are vital factors regulating microglial activation, and CD147 is a key MMP inducer, which can induce inflammation by inducing MMPs. However, whether it is involved in the regulation of microglial activation has not been reported. In this study, the role of CD147 in LPS-induced microglial inflammatory activation was investigated by establishing in vivo and in vitro models. The results suggested that LPS-induced microglial activation was accompanied by the induction of CD147 expression while the inhibition of CD147 expression could inhibit LPS-induced microglial inflammatory activation. In addition, the results also indicated that the role of CD147 in LPS-induced pro-inflammatory activation of microglia was related to its downstream MMP-3, MMP-8, and autophagy. Furthermore, the inhibition of MMP-3, MMP-8, and autophagy attenuated LPS-induced inflammatory activation of microglia. At the same time, there was a certain interaction between MMPs and autophagy, which is shown that inhibiting the expression of MMPs could inhibit autophagy, whereas inhibiting autophagy could inhibit the expression of MMPs. Taken together, we provided the first evidence that CD147/MMPs can be involved in LPS-induced inflammatory activation of microglia through an autophagy-dependent manner. Supplementary Information The online version contains supplementary material available at 10.1007/s11356-022-24292-y.

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Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression

Yao

Liu

Tang

et al. 2022

Environ Sci Pollut Res

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show abstract

“…According to experimental work, microglial reactivity is enhanced with parkinsonism-inducing toxicants ( Dai et al, 2012 ; Klusa et al, 2010 ; Swarnkar et al, 2013 ; Zhang et al, 2021b ) and with preformed fibrils (PFFs) synthesized from recombinant α-synuclein ( Duffy et al, 2018b ; Harms et al, 2017 ; Stoll and Sortwell, 2022 ; Thakur et al, 2017 ; Verma et al, 2021 ). PFF-induced microgliosis has also been shown to precede neuronal loss in animal models ( Duffy et al, 2018b ).…”

Section: Introductionmentioning

confidence: 99%

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

Bhatia

Jamenis

Abbas

et al. 2023

Neurobiology of Disease

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Acute exposure to paraquat affects the phenotypic differentiation of substantia nigra microglia in rats

Cited by 2 publications

References 35 publications

Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression

Lipopolysaccharide induces inflammatory microglial activation through CD147-mediated matrix metalloproteinase expression

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes

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