Acute febrile neutrophilic dermatosis (Sweet's syndrome) in a patient with biliary sepsis

Yong, Adrian Sze Wai; Lee, Kevin Y. C.; Murphy, Joseph G.; Phillips, M; Rushbrook, Simon; Garioch, J.

doi:10.1136/postgradmedj-2013-132162

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Neutrophilic Dermatosis Accompanying Acute Cholecystitis1

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“…In the published work, an association between acute cholecystitis and ND has not been reported, although Sweet syndrome complicated with biliary sepsis has been reported. 5 Even in the confusing condition such as that of our case, it is important to evaluate the pathological condition correctly in order to provide appropriate treatment.…”

Section: Neutrophilic Dermatosis Accompanying Acute Cholecystitismentioning

confidence: 86%

Neutrophilic dermatosis accompanying acute cholecystitis

Hoshina

Tsujiwaki

Furuya

et al. 2016

The Journal of Dermatology

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Section: Neutrophilic Dermatosis Accompanying Acute Cholecystitismentioning

confidence: 86%

Neutrophilic dermatosis accompanying acute cholecystitis

Hoshina

Tsujiwaki

Furuya

et al. 2016

The Journal of Dermatology

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Insights Into the Pathogenesis of Sweet's Syndrome

2019

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Sweet's syndrome, also known as Acute Febrile Neutrophilic Dermatosis, is a rare inflammatory condition. It is considered to be the prototype disease of neutrophilic dermatoses, and presents with acute onset dermal neutrophilic lesions, leukocytosis, and pyrexia. Several variants have been described both clinically and histopathologically. Classifications include classic Sweet's syndrome, malignancy associated, and drug induced. The cellular and molecular mechanisms involved in Sweet's syndrome have been difficult to elucidate due to the large variety of conditions leading to a common clinical presentation. The exact pathogenesis of Sweet's syndrome is unclear; however, new discoveries have shed light on the role of inflammatory signaling, disease induction, and relationship with malignancy. These findings include an improved understanding of inflammasome activation, malignant transformation into dermal infiltrating neutrophils, and genetic contributions. Continued investigations into effective treatments and targeted therapy will benefit patients and improve our molecular understanding of inflammatory diseases, including Sweet's syndrome.

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Acute febrile neutrophilic dermatosis (Sweet's syndrome) in a patient with biliary sepsis

Cited by 2 publications

References 6 publications

Neutrophilic dermatosis accompanying acute cholecystitis

Neutrophilic dermatosis accompanying acute cholecystitis

Insights Into the Pathogenesis of Sweet's Syndrome

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