Acute febrile neutrophilic dermatosis (Sweet's syndrome) in a patient with relapsing polychondritis

Abstract

Acute febrile neutrophilic dermatosis (Sweet's syndrome) in a patient with relapsing polychondritis CORRESPONDENCE 931

Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

“…There are also several conditions for which the association with Sweet's syndrome is possibly bona fide (Table 6). In addition, the validity of the association between Sweet's syndrome and many of the conditions that have been observed in patients with the dermatosis remains to be established (Table 7) (Figure 9); indeed, the detection of that condition in an individual with Sweet's syndrome may merely represent a coincidental occurrence [1,2,5,11-20,30,36-43,69-126,158-161,164,166,186-190,195,214,231,236,259-339,401,404,407,409-411,413,415,417-419,421,424,425,431,433]. …”

“…However, eosinophils have been observed within the dermal infiltrate in the Sweet's syndrome skin lesions of some patients with either the classical [11,167,168,195,202-204,212] or the drug-induced [84,107,110,111] dermatosis. Occasionally, lymphocytes or histiocytes may also be present in the inflammatory infiltrate [11,104,167,168,198-200,425].…”

“…However, neutrophils can also be present in the epidermis [17,197] or adipose tissue. For example, exocytosis of neutrophils into the overlying epidermis has been observed as either neutrophilic spongiotic vesicles [194] or subcorneal pustules [12,80,167,195,196]. The condition is referred to as "subcutaneous Sweet's syndrome" when the neutrophils are located either entirely or only partially in the subcutaneous fat [4,8,12,17,99,119,164-184,397,399,417].…”

Concomitant Sweet’s Syndrome and Relapsing Polychondritis

“…Seven patients were from a study of 200 cases of RP in Paris; no temporal association was described (5). Two patients from case reports manifested RP followed by SS with an interval of months to years., and in one patient SS was followed by RP (6)(7)(8). Six ofthe cases were associated with malignancies, mainly haematological.…”

Síndrome de Sweet e policondrite recidivante reveladores de síndrome mielodisplásica

“…In these, SS preceded the appearance of PR in two cases, occurred after its appearance in four cases and was concomitant in one case. [9][10][11][12][13][14][15] Twelve patients with SS and PR had associated neoplasia: MDS in 11 cases and bladder cancer in one case.…”