Acute fibrinous and organizing pneumonia in a patient with Sjogren’s syndrome

Fasanya, Adebayo; Gandhi, Viral; DiCarlo, Christina; Thirumala, Raghukumar

doi:10.1016/j.rmcr.2016.11.010

Cited by 9 publications

(8 citation statements)

References 13 publications

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“…AFOP has been reported in the post-transplant period with features similar to acute rejection, primary graft dysfunction or infections, such as cytomegalovirus (CMV) [ 8 ]. In our case report, there was no evidence of connective tissue disorder, environmental toxins or chemical exposure or any infection, and it is possible that this case, as in many cases was an idiopathic case of AFOP [ 2 , 3 , 6 , 9 , 10 ].…”

Section: Discussionmentioning

confidence: 80%

Acute Fibrinous and Organizing Pneumonia: A Case Report and Review of the Literature

et al. 2017

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Patient: Female, 35Final Diagnosis: Acute fibrinous and organizing pneumoniaSymptoms: Shortness of breathMedication: —Clinical Procedure: Video assisted thoracoscopic lung biopsySpecialty: PulmonologyObjective:Unknown ethiologyBackground:Acute fibrinous organizing pneumonia (AFOP) is a rare condition of the lung that is associated with acute lung injury, and has a poor prognosis. AFOP is characterized histologically by intra-alveolar fibrin. AFOP has been described to be associated with lung infections, connective tissue disorders, drugs, toxic environmental exposure, and in lung transplantation. However, most cases of AFOP remain idiopathic, and because the condition can present with a wide variety of clinical manifestations, open lung biopsy or video-assisted thoracoscopic (VAT) lung biopsy is necessary for the diagnosis. Currently, treatments for AFOP remain under investigation.Case Report:A 35-year-old woman presented with a cough and dyspnea, and was initially diagnosed to have pneumonia. Due to the progression of her symptoms and increasing respiratory failure she underwent video-assisted thoracoscopic (VAT) biopsy and was diagnosed with AFOP, 19 days following hospital admission. She was treated with mechanical ventilation, intravenous steroids, and cyclophosphamide. She required tracheostomy after 14 days of mechanical ventilation and died two weeks later.Conclusions:AFOP is an uncommon clinical condition, with a poor prognosis, which often has a delay in diagnosis. Some patients benefit from steroids and immunosuppressive therapy. Currently, new treatments for AFOP are under investigation.

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Section: Discussionmentioning

confidence: 80%

Acute Fibrinous and Organizing Pneumonia: A Case Report and Review of the Literature

et al. 2017

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“…The two patients in this case report did not have possible related infections, drugs, environmental exposure or chemical exposure. Many idiopathic cases of AFOP have been previously reported [4–7].…”

Section: Discussionmentioning

confidence: 99%

Acute fibrinous and organizing pneumonia: two case reports and literature review

Yin

Zha

et al. 2019

BMC Pulm Med

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Background Acute fibrinous and organizing pneumonia (AFOP) is a very rare form of acute or subacute lung injury, which is characterized by patches of “fibrin balls” distributed within the alveoli. Given the lack of typical clinical manifestations, AFOP is often misdiagnosed as pneumonia, tuberculosis, etc. Definitive diagnosis is obtained from a lung biopsy. Corticosteroids are usually effective. Case presentation We report two cases of patients with histopathological manifestations of AFOP, which were significantly improved after corticosteroid therapy. Previous reports of the clinical and pathological characteristics of AFOP were reviewed to improve clinicians’ understanding of this disease. Conclusions Early identification and diagnosis are very important for AFOP treatment. The prognosis is acceptable after timely and effective treatment.

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“…AFOP could be idiopathic or could also be associated with other diseases, lung transplantation [ 8 ], connective tissue disease [ 9 , 10 ], infection [ 11 , 12 ], drug reactions [ 13 ], etc. For this case, the patient was a general farmer with a history of contact with an herbicide prior to symptom onset.…”

Section: Discussionmentioning

confidence: 99%

A case of herbicide-induced acute fibrinous and organizing pneumonia?

et al. 2017

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BackgroundTo improve the understanding of acute fibrinous and organizing pneumonia (AFOP), we present one case of AFOP proven by percutaneous lung biopsy along with clinical features, chest imaging and pathology.Case presentationA 50-year-old man was admitted to our department after he was given empiric therapy for community-acquired pneumonia (CAP). The clinical symptoms of the patient were dry cough, chills, night sweats and high fevers. Chest computed tomography (CT) scan showed a high-density shadow in the right lung lobe, similar to lobular pneumonia. The patient was preliminarily diagnosed with community-acquired pneumonia; however, antibacterial treatment was ineffective. To confirm the diagnosis, we performed bronchoscopy and percutaneous lung biopsy; pathology was consistent with AFOP. After he was treated with glucocorticoids, the patient’s symptoms were relieved, and the shadow seen on imaging dissipated during the follow-up period.ConclusionsAFOP is a rare histopathological diagnosis that can be easily misdiagnosed. Clinicians need to consider the possibility of AFOP in the case of invalid antibacterial therapy.

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Acute fibrinous and organizing pneumonia in a patient with Sjogren’s syndrome

Cited by 9 publications

References 13 publications

Acute Fibrinous and Organizing Pneumonia: A Case Report and Review of the Literature

Acute Fibrinous and Organizing Pneumonia: A Case Report and Review of the Literature

Acute fibrinous and organizing pneumonia: two case reports and literature review

A case of herbicide-induced acute fibrinous and organizing pneumonia?

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