Acute Flaccid Myelitis: Characteristics and Outcomes of 2014 and 2016 Cases at a Single Center

Matesanz, Susan; McGuire, Jennifer L.; Hopkins, Sarah

doi:10.1016/j.jpeds.2019.07.015

Cited by 10 publications

(13 citation statements)

References 18 publications

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“…To date, few studies have looked at functional outcomes in the context of rehabilitative intervention in children with AFM. 34,35 We retrospectively calculated the mRS so the change in our cohort could be interpreted in the context of previously reported outcomes; change on this measure was similar to that previously reported, even if the effect of the specific rehabilitative interventions cannot be compared directly.…”

Section: Discussionmentioning

confidence: 89%

Improvements in Function Following Inpatient Activity-Based Therapy for Children With Acute Flaccid Myelitis

Hagen

Porter

Martin

et al. 2020

Topics in Spinal Cord Injury Rehabilitation

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Background: Acute flaccid myelitis (AFM) is an illness defined by rapid onset of flaccid paralysis in one or more limbs or bulbar muscles, with MRI findings of predominantly spinal cord gray matter abnormalities spanning one or more spinal segments following a viral illness. Individuals with AFM may require rehabilitation to promote recovery. Activity-based restorative therapy (ABRT) has previously been shown to result in positive outcomes in children with neurologic deficits related to AFM. Objectives: This study examined functional changes in a group of children with AFM who participated in ABRT in an inpatient setting. Methods: Retrospective chart review of children with AFM admitted to a single inpatient rehabilitation unit from 2014 to 2018. Children were assessed using the Functional Independence Measure for Children (WeeFIM), Manual Muscle Testing (MMT), Spinal Cord Independence Measure (SCIM), and the Physical Abilities and Mobility Scale (PAMS) as part of routine clinical care; the Modified Rankin Scale for Neurologic Disability was completed retrospectively. Results: Children showed significant improvements across all outcome measures, with effect sizes ranging from moderate to large. Significant change was also seen across all muscle groups on MMT, with effect sizes ranging from small to large. Consistent with previous reports, children demonstrated better function in distal than proximal muscle groups at both admission and discharge. Conclusion: Children with AFM who participated in ABRT increased muscle strength and made functional gains across all outcome measures. These results support the utility of rehabilitation in the long-term care of children with AFM and residual neurologic deficit.

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Section: Discussionmentioning

confidence: 89%

Improvements in Function Following Inpatient Activity-Based Therapy for Children With Acute Flaccid Myelitis

Hagen

Porter

Martin

et al. 2020

Topics in Spinal Cord Injury Rehabilitation

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“…After removal of duplicates and initial screening, 500 were reviewed and assessed for eligibility. After application of inclusion and exclusion criteria, 99 articles were included in this study (55 case reports/series, 1,4–7,9–57 33 retrospective cohort studies, 2,3,58–88 seven cross-sectional studies, 89–95 and four case-control studies 96–99 ) (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Acute Flaccid Myelitis: Review of Clinical Features, Diagnosis, and Management with Nerve Transfers

Kozlowski¹,

Linzey

Muhlestein

et al. 2022

Plastic &Amp; Reconstructive Surgery

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cute flaccid myelitis (AFM) is a polio-like illness in children that causes inflammation of the spinal cord gray matter. AFM is characterized by a viral prodrome that is followed by mild to severe weakness in one to four limbs that can be persistent even after conservative management. 1 Almost one-third of patients admitted to the hospital require intubation because of weakness of respiratory muscles or bulbar muscle weakness. 2 AFM was initially recognized after the first major outbreak in the United States in 2014.

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“…Multiple sclerosis classically causes a partial myelitis with predilection for the white matter tracts, while other causes may result in a mix of gray and white matter involvement (4). In recent years, outbreaks of a gray-matter centric myelitis associated with enterovirus D68 (EVD68) have resulted in flaccid paralysis in children (5). Such examples highlight the nuance in characterizing myelopathies in the transverse plane.…”

Section: Immune-mediated Myelopathies Are Radiographically Heterogeneousmentioning

confidence: 99%

Revisiting Transverse Myelitis: Moving Toward a New Nomenclature

Blackburn

Greenberg

2020

Front. Neurol.

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Acute Flaccid Myelitis: Characteristics and Outcomes of 2014 and 2016 Cases at a Single Center

Cited by 10 publications

References 18 publications

Improvements in Function Following Inpatient Activity-Based Therapy for Children With Acute Flaccid Myelitis

Improvements in Function Following Inpatient Activity-Based Therapy for Children With Acute Flaccid Myelitis

Acute Flaccid Myelitis: Review of Clinical Features, Diagnosis, and Management with Nerve Transfers

Revisiting Transverse Myelitis: Moving Toward a New Nomenclature

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