Acute Flaccid paralysis in adults: Our experience

Kaushik, Rupesh; Kharbanda, P; Bhalla, Ashish; Rajan, Roopa; Prabhakar, Sudesh

doi:10.4103/0974-2700.136847

Cited by 17 publications

(10 citation statements)

References 10 publications

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“…Incidence of MFS is often less frequently reported in previous studies [23,24], as no MFS patients were reported during our study period. and descending pattern of weakness in 6.8% [15]. Facial palsy was seen in more than half of the GBS patients and bilateral weakness pattern was seen in most of them which was consistent with previous studies [25,26].…”

Section: Discussionsupporting

confidence: 91%

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Clinical Variants and Evaluation of Clinical Severity of Guillain Barre Syndrome in a Tertiary Care Hospital of Nepal

Ojha¹,

Oli²,

Gajurel³

et al. 2019

Preprint

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Background Guillain Barre Syndrome(GBS) is an acute, frequently severe, and fulminant polyradiculoneuropathy that is autoimmune in nature. Our aim is to evaluate the grading of disability and outcome among different variants of GBS. Methods All consecutive patients recruited prospectively in the study were of age ≥16 years and were being admitted in department of Neurology of Tribhuvan University Teaching Hospital, Kathmandu, Nepal from 2016 March to 2017 February. All demographic, historical and clinical data were collected. Nerve conduction study, cerebrospinal fluid analysis along with clinical features were evaluated to assess the diagnostic certainty of Brighton Criteria. Overall disability sum score (ODSS) and GBS disability score were assessed in all patients. The study protocol was approved by the Institutional Review Boards. Results A total of 46 patients were included: male patients being predominant (70% vs 30%), mean age= 36.5±16.2, range = 16 - 80 years. Thirty-two patients (70%) were an axonal variant, acute motor axonal neuropathy being more common (18 patients), and 14 patients were acute motor and sensory axonal neuropathy. Fourteen patients (30%) were demyelinating type, out of which 11 patients had both motor and sensory features, and only 3 patients were pure motor demyelinating type. Axonal variants were found to have higher ODSS during nadir (p=0.024) and discharge(p=0.004), and also higher GBS disability score during nadir (p=0.012) and discharge (p=0.021). Acute motor axonal neuropathy (AMAN) had higher GBS disability score than acute inflammatory demyelinating polyneuropathy (AIDP) at nadir (p=0.034) and discharge (p=0.039). Conclusions Axonal neuropathy variants are predominant among the Nepalese population and are clinically severe than demyelinating variants. Further, prospective study of longer duration to include larger number of patients will be needed.

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Section: Discussionsupporting

confidence: 91%

“…Our study showed men are more likely to have GBS than women which was consistent with most of the GBS studies [14][15][16]. GBS can affect people of all ages, but majority of patients were below the age of 40 years.…”

Section: Discussionsupporting

confidence: 90%

Clinical Variants and Evaluation of Clinical Severity of Guillain Barre Syndrome in a Tertiary Care Hospital of Nepal

Ojha¹,

Oli²,

Gajurel³

et al. 2019

Preprint

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“…Neuroparalytic snakebite has been previously reported as a significant cause of acute flaccid paralysis in young rural men from Northern India. [2] Our study shows a male preponderance among patients with acute flaccid paralysis Males constituted 69/97 (71.1%) of total number of cases. This is attributed to higher proportion of males in both snake envenomation and LGBS groups.…”

Section: Discussionmentioning

confidence: 50%

Etiology and Outcomes of Acute Flaccid Paralysis in Adults: A Study in Tertiary Care Center.

Gupta

Daid

2020

Preprint

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INTRODUCTION: The World Health Organization defines acute flaccid paralysis syndrome as rapid onset of weakness of an individual's extremities, often including weakness of the muscles of respiration and swallowing, progressing to maximum severity within 1 to 10 days. We carried out this observational study in a tertiary care center in North India with the aim of determining the etiology and outcome of Acute Flaccid Paralysis in adults. METHODS: In this observational study, all cases diagnosed with Acute flaccid paralysis admitted to the tertiary care center from 1st January 2015 till 30th June 2016 were enrolled. Ninety-seven consecutive patients of age above 18 years presenting with weakness of duration less than two weeks were enrolled after obtaining informed consent and various investigations were studied. RESULTS: The study analyzed data of 97 patients presenting with flaccid paralysis. They were analyzed for the demographic data, clinical features, investigations, electrophysiological data, and results of the treatment. The most common etiology of acute flaccid paralysis in this entire population was GBS, which was responsible for 50.5% of the cases, followed by the Hypokalemic paralysis (25.8%) followed by neuroparalytic snake bite (15.5%).In this study, 48% of patients with hypokalemic paralysis had a secondary cause for their condition. Primary hypokalemic periodic paralysis occurred in 52% of patients. CONCLUSIONS: In this observational study, GBS was found to be the most common cause for Acute Flaccid Paralysis followed by Neuroparalytic snake bite. Respiratory paralysis was an important risk factor associated with mortality.

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“…AIP as cause of AFP was noted in 4.5% patients. [ 17 ] In a descriptive observational study, among 108 patients presenting with features of acute polyneuropathy or encephalopathy associated with pain and/or dysautonomia, porphyrin metabolites were screened. AIP was diagnosed in 12 patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical, biochemical characteristics and hospital outcome of acute intermittent porphyria patients: A descriptive study from North India

Kumar

Bhalla

Sharma

et al. 2017

Ann Indian Acad Neurol

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Acute Flaccid paralysis in adults: Our experience

Cited by 17 publications

References 10 publications

Clinical Variants and Evaluation of Clinical Severity of Guillain Barre Syndrome in a Tertiary Care Hospital of Nepal

Clinical Variants and Evaluation of Clinical Severity of Guillain Barre Syndrome in a Tertiary Care Hospital of Nepal

Etiology and Outcomes of Acute Flaccid Paralysis in Adults: A Study in Tertiary Care Center.

Clinical, biochemical characteristics and hospital outcome of acute intermittent porphyria patients: A descriptive study from North India

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