Acute Fulminant Multiple Sclerosis and Plasma Exchange

Jacquerye, P.; Ossemann, Michel; Laloux, Patrice; Dive, Alain; Coene, Beatrijs De

doi:10.1159/000008030

Cited by 16 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Whilst further prospective, blinded and sham controlled studies are required to examine whether this tentative observation is valid, or a result of either sub-optimal trial design or merely regression to the mean in a population selected for high relapse rate it does at least suggest the possibility that the plasma exchange may not only promote recovery from acute relapse but also prospectively reduce further attacks for a period of time. Indeed of three studies [24][25][26] which have looked at the effects of plasma exchange on brain MRI gadolinium-enhancing lesions one found a reduction [24] in the number of gadolinium-enhancing lesions following PE; one found no change [26] and the other reported an increase [25]. It is therefore suggested that PE may modify the overall inflammatory process [25].…”

Section: Discussionmentioning

confidence: 99%

Plasma exchange in episodes of severe inflammatory demyelination of the central nervous system

et al. 2004

View full text Add to dashboard Cite

The standard therapy for episodes of severe acute inflammatory demyelinating disease of the central nervous system is high dose intravenous corticosteroids. A small proportion of patients fail to improve with this regime and their prognosis can become grave. A recent sham controlled double blind crossover trial in this group of patients demonstrated a significant benefit from plasma exchange. We report six patients with severe acute steroid-insensitive inflammatory demyelinating disease of the central nervous system treated with plasma exchange. We observed a clear improvement in five of these six patients. Whilst complications of plasma exchange occurred these did not outweigh the benefits. Our study supports the use of plasma exchange in severe acute steroid-insensitive inflammatory disease of the central nervous system.

show abstract

Section: Discussionmentioning

confidence: 99%

Plasma exchange in episodes of severe inflammatory demyelination of the central nervous system

et al. 2004

View full text Add to dashboard Cite

show abstract

“…This highly aggressive form is defined by its swift and relentless decline to significant disability or even death, often within a few weeks or months after the onset of the initial attack. It is characterized by widespread and progressive cerebral white matter destruction or by severe pathological involvement of clinically strategic regions such as brainstem, resulting in bulbar paralysis [12].…”

Section: Optic-spinal Form Of Multiple Sclerosismentioning

confidence: 99%

“…Multiple sclerosis (MS) or Demyelinating disease [12] is a disease in which the nerves of the central nervous system (brain and spinal cord) degenerate [13, 17 and 31]. Myelin, which provides a covering or insulation for nerves, improves the conduction of impulses along the nerves and also is important for maintaining the health of the nerves.…”

Section: Introductionmentioning

confidence: 99%

Cognitive analysis of multiple sclerosis utilizing fuzzy cluster means

Agboizebeta¹

2012

IJAIA

View full text Add to dashboard Cite

Multiple sclerosis, often called MS, is a disease that affects the central nervous system (the brain and spinal cord). Myelin provides insulation for nerve cells improves the conduction of impulses along the nerves and is important for maintaining the health of the nerves. In multiple sclerosis, inflammation causes the myelin to disappear. Genetic factors, environmental issues and viral infection may also play a role in developing the disease. Ms is characterized by life threatening symptoms such as; loss of balance, hearing problem and depression. The application of Fuzzy Cluster Means (FCM or Fuzzy C-Mean) analysis to the diagnosis of different forms of multiple sclerosis is the focal point of this paper. Application of cluster analysis involves a sequence of methodological and analytical decision steps that enhances the quality and meaning of the clusters produced. Uncertainties associated with analysis of multiple sclerosis test data are eliminated by the system

show abstract

“…Plasmapheresis is utilized in the acute treatment of both MS and ADEM [73][74][75][76][77][78]. It has been studied in two placebocontrolled trials to date.…”

Section: Acute Demyelinating Encephalomyelitis (Adem)/ Hyperacute Mulmentioning

confidence: 99%

“…Seventy-five percent of responders do so within three exchanges or 5 days of treatment [81]. A typical treatment regimen is single volume plasmapheresis daily or every other day for 3-5 exchanges, though prolonged therapy (up to 20 exchanges) has been reported [73][74][75][76][77][78].…”

Section: Acute Demyelinating Encephalomyelitis (Adem)/ Hyperacute Mulmentioning

confidence: 99%