Acute Gastroenteritis

Granado-Villar, Deise; Sautu, Beatriz Cunill-De; Granados, Andrea

doi:10.1542/pir.33.11.487

Cited by 13 publications

(13 citation statements)

References 10 publications

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“…Annually, 700 million cases of gastroenteritis are reported worldwide, resulting in 0.8–2 million deaths, 1 making it the second leading cause of death among infants and children under 5 years of age 2 . Various pathogens including bacteria, viruses, protozoa and helminths can cause this disease 3 . Among them, viruses are the most important cause of AGE in the world, causing about 70% of cases 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Among them, viruses are the most important cause of AGE in the world, causing about 70% of cases 2 . Viral gastroenteritis is usually associated with non‐bloody watery diarrhea and low‐grade fever 3 . Rotaviruses (RVs), enteric adenoviruses (EAdVs), astroviruses (AstVs), enteroviruses (EVs) and caliciviruses including noroviruses (NoVs) and Sapoviruses (SaVs) are well‐known viral agents causing AGE 3,4 …”

Section: Introductionmentioning

confidence: 99%

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Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

Razizadeh

Khatami

Zarei

2021

Reviews in Medical Virology

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Sapovirus (SaV) is an emerging cause of children gastrointestinal complications such as acute gastroenteritis (AGE). The aim of the present systematic review and metaanalysis was to estimate the global prevalence of the SaV in children and association of infection with SaVs and AGE in children based on case-control studies. Four international databases (PubMed, Scopus, Web of Sciences and Google Scholar) were used to retrieve English-language studies published between January 2000 and December 2020. Comprehensive Meta-Analysis software was applied to estimate the overall prevalence, publication bias and heterogeneity index. The pooled prevalence of SaV infection among children with gastroenteritis was 3.4% [95% confidence interval (CI): 2.9%-3.9%] based on a random-effects meta-analysis.Genogroup I was the dominant genogroup of SaV in children with gastroenteritis [2.2% (95% CI: 1.6%-3.0%)], association analysis showed that SaV was associated with gastroenteritis [OR: 1.843 (95% CI: 1.27-2.66)]. Given the significant prevalence of the virus in children, it is necessary to pay more attention to this situation.Therefore, preventive health measures in children should be a priority.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

Razizadeh

Khatami

Zarei

2021

Reviews in Medical Virology

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“…Every year, acute gastroenteritis (AGE) is responsible for about 1.7 billion diarrhoea cases among children younger than age 5, of which about one‐third lose their lives due to the disease complications, making it the second leading cause of death in this age group 1 . Some pathogens are involved in the development of AGE, of which, viruses are responsible for about 70% of cases 2,3 . Rotavirus (RoV), Norovirus (NoV), Enteric Adenovirus (EAdV), Human Astrovirus (HAstV), and Sapovirus (SaV) are the most well‐known viruses in the development of AGE 1,4,5 .…”

Section: Introductionmentioning

confidence: 99%

An annoying enteric virus: A systematic review and meta‐analysis of human astroviruses and gastrointestinal complications in children

Razizadeh

Pourrostami

Kachooei

et al. 2022

Reviews in Medical Virology

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Human astroviruses (HAstVs) have frequently been detected in individuals with acute gastroenteritis (AGE). However, a precise estimate of the overall prevalence of the virus in children with AGE as well as the possible association of the virus with gastrointestinal complications is not available up to now. The present study estimated the overall prevalence of HAstVs in children with gastrointestinal complications as well as the association between the virus and symptoms. We systematically searched four international databases (PubMed, Scopus, Web of Science, and Google scholar) to find studies on the prevalence of HAstVs in people with AGE published between Jan 2000 and Sep 2021. Analysis of the 223 included studies presented a 4.2% (95% CI 3.8%–4.8%) prevalence of the virus in AGE individuals. Based on case‐control studies, a significant association between these viruses and AGE was detected (OR: 2.059, 95% CI; 1.438–2.949). HAstV‐1 and HAstV‐VA‐2 is the most and least common genotypes in the AGE patients, respectively (59.0%, 95% CI: 52.1%–65.6% vs. 4.9%, 95% CI: 2.6%–9.1%). Due to the statistically significant association between HAstV and gastrointestinal complications, more attention should be paid to these viruses in people with AGE and more studies should employ case‐control design.

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“…[5][6][7][8][9][10][11] Among the antiemetic drugs that are available, ondansetron has the strongest evidence of efficacy in the setting of AGE and is the most frequently used antiemetic for this indication with clinical pathways to promote its use. [5][6][7][8][9][10][11] Racial and ethnic disparities exist in the United States, and there is growing literature describing these disparities in health care. 12,13 Studies have found inequities in nearly every aspect of ED care, including triage, [14][15][16][17][18] wait time, [19][20][21][22] ED length of stay, 23 and the quality of care that is delivered.…”

mentioning

confidence: 99%

“…Symptoms of AGE include nausea, vomiting, and diarrhea that can lead to dehydration. The administration of antiemetic medications to children with AGE and dehydration is common and effective 2–11 . Antiemetic use has been shown to be successful in improving the efficacy of oral rehydration therapy as well as effective in reducing ongoing vomiting and the need for intravenous (IV) fluid administration or hospitalization 1–4 .…”

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confidence: 99%

Racial and Ethnic Differences in Ondansetron Use for Acute Gastroenteritis in Children

et al. 2022

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Objectives: There is limited research examining racial/ethnic disparities in antiemetic use for acute gastroenteritis (AGE). We assessed racial/ethnic differences in the care of children with AGE. Methods:The Pediatric Health Information System was used to conduct a retrospective cohort study of children 6 months to 6 years old with AGE seen in participating emergency departments from 2016 to 2018. Cases were identified using International Classification of Diseases, Tenth Revision codes. The primary outcome was administration of ondansetron, secondary outcomes were administration of intravenous (IV) fluids and hospitalization, and primary predictor was race/ethnicity. Multivariable logistic regression followed by a mixed model adjusted for sex, age, insurance, and hospital to examine the association of race/ethnicity with each outcome.Results: There were 78,019 encounters included; 24.8% of patients were non-Hispanic White (NHW), 29.0% non-Hispanic Black (NHB), 37.3% Hispanic, and 8.9% other non-Hispanic (NH) race/ethnicity. Compared with NHW patients, minority children were more likely to receive ondansetron

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Acute Gastroenteritis

Cited by 13 publications

References 10 publications

Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

Global molecular prevalence and genotype distribution of Sapovirus in children with gastrointestinal complications: A systematic review and meta‐analysis

An annoying enteric virus: A systematic review and meta‐analysis of human astroviruses and gastrointestinal complications in children

Racial and Ethnic Differences in Ondansetron Use for Acute Gastroenteritis in Children

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