Acute Generalized Exanthematous Pustulosis (AGEP), an Uncommon Condition in Children: Case Report and Review of the Literature

Meadows, Kappa P.; Egan, Conleth A.; Vanderhooft, Sheryll L.

doi:10.1046/j.1525-1470.2000.017005399.x

Cited by 40 publications

(27 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the withdrawal of the drug, pustules resolve spontaneously within a few (4-10 days) days and are in typical cases followed by a characteristic post-pustular pin-point desquamation. [1,3,4] It seems that more than 90 % of cases with AGEP are drug induced. A wide range of drugs has been suspected of causing these reactions and antibacterials are being the most frequent triggers.…”

Section: Discussionmentioning

confidence: 99%

“…[5] Typical histopathology shows spongioform subcorneal and/or intraepidermal pustules, and often marked perivascular infiltrates with neutropils. [3] Also AGEP is a disease that is rarely seen in childhood. [3] In this case the onset of the disease about five day after the administration of the cetirizine, neutrophylia, typical histopathologic examination and rapidly response to cessation of the drug lead us to the diagnosis of AGEP.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Also AGEP is a disease that is rarely seen in childhood. [3] In this case the onset of the disease about five day after the administration of the cetirizine, neutrophylia, typical histopathologic examination and rapidly response to cessation of the drug lead us to the diagnosis of AGEP. The main differential diagnosis clinically and histologically is pustular psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…[3] It is characterized by widespread, sterile pustular rash. The eruption is of sudden onset and appears 7-10 days after the medication is started.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute Generalized Exanthematous Pustulosis (AGEP) Induced by Cetirizine in a Child A Case Report

Pancar¹,

Kalkan²,

Dürer³

2016

Ann Clin Anal Med

View full text Add to dashboard Cite

ÖzetAkut Generalize Ekzantematöz Püstüloz (AGEP), yaygın foliküler olmayan steril püstüller ile karakterize nadir bir kutanöz döküntüdür. AGEP çocuklarda az rastlanılan bir hastalıktır ve genellikle ilaçlara bağlı ortaya çıkmaktadır. Antibiyotikler, sulfonamidler, ateş düşürücü ve ağrı kesiciler bu ilaç döküntüsünün en sık nedenleridir. Setrizin çocuklarda angioödem, atopik dermatit ve ürtiker tedavisinde sıklıkla kullanılan ikinci kuşak antihistaminiktir. Literatürde ise setrizin ile indük-lenen AGEP olgusu yer almamaktadır. Bu olguda oniki yaşında kız çocuk gövdede yer alan ürtikeryal plaklar ile başvurmuş ve tedavi olarak kullanılan setrizin (günde tek doz) ile foliküler olmayan püstül formasyonu gelişmiştir. Tedavinin sonlandırıl-masından sonlandırılmasının ardından deskuamasyon ile püstüller tamamen gerilemiş ve oral provakasyon testine yanıtta pozitif olarak alınmıştır. Bu olguda ço-cukluk yaş grubunda antihistaminiklerin (setrizin) AGEP nedeni olabileceğini gös-termek amacıyla sunulmuştur. Anahtar Kelimeler AGEP; Çocuklukçağı İlaç Reaksiyonları; Setrizin AbstractAcute Generalized Exanthematous Pustulosis (AGEP), is a rare cutaneous rash characterized by widespread sterile non-follicular pustules. AGEP is a rare disease in childhood and it is often due to drugs. Antibiotics, sulphanamides and antipyretic-analgesics are the main reasons of this drug reaction . Cetirizine is a second generation antihistamine is often used in the treatment of angioedema, atopic dermatitis and urticaria in children. Cetirizine induced AGEP was not reported in the literature. In this case a twelve year old child was admitted with urticarial plaques located on her trunk. She developed maculopapular lesions and pustular eruption with Cetirizine (once a day) treatment. Cetirizine was stopped and the nonfollicular pustules cleared with a desquamation. The result of the oral challenge test was positive. We present this rare case to show that the antihistamines (cetirizine) may cause AGEP in childhood.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…[3] It is characterized by widespread, sterile pustular rash. The eruption is of sudden onset and appears 7-10 days after the medication is started.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acute Generalized Exanthematous Pustulosis (AGEP) Induced by Cetirizine in a Child A Case Report

Pancar¹,

Kalkan²,

Dürer³

2016

Ann Clin Anal Med

View full text Add to dashboard Cite

show abstract

“…beta-lactams and doxycycline), nystatin, furosemide, terbinafine, diltiazem and paracetamol (very commonly used in children) [5,6,7,8,9,10,11]. In some cases, a viral aetiology such as enterovirus was identified.…”

mentioning

confidence: 99%