Acute generalized exanthematous pustulosis due to ceftriaxone: Report of a pediatric case with recurrence after positive patch test

Abstract

Acute generalized exanthematous pustulosis (AGEP) is seen uncommonly in children and sometimes shows atypical clinical features in this population. Patch testing can be used effectively in children for the confirmation of the culprit drug in cases of multiple drug use. Here, we report a rare, pediatric case of ceftriaxone‐induced AGEP confirmed by patch testing with subsequent recurrence of the skin eruption.

Systemic pustular allergic contact dermatitis induced by thioureas: Report of a case with recurrence upon patch testing

“…The widespread micropustules were also found on the patch test reactions to thioureas, suggesting the same cellular pathogenesis was involved at the local patch test site than at the systemic level. During histopathological analysis, the observed pustular spongiosis is consistent with a subtype of ACD not usually found in AGEP 4,5 …”

“…During histopathological analysis, the observed pustular spongiosis is consistent with a subtype of ACD not usually found in AGEP. 4,5…”

Hydroxychloroquine‐induced acute generalized exanthematous pustulosis: a series of seven patients and review of the literature

“…No HCQ‐induced AGEP cases have been reported among the 45 patients with AGEP 23 . Drug patch testing in patients with AGEP is considered safe, although relapse during patch testing has been reported 24 . This test was performed in three of our patients, showing a positive result in only one case.…”

“…23 Drug patch testing in patients with AGEP is considered safe, although relapse during patch testing has been reported. 24 This test was performed in three of our patients, showing a positive result in only one case. Value and safety of Intradermal reaction and prick testing in AGEP are unknown, but systemic provocation of suspected drug or cross-reactive drugs is contraindicated.…”

Generalized pustular figurate erythema first report in two COVID‐19 patients on hydroxychloroquine

“…AGEP has been linked with many medications, including teicoplanin and lopinanvir that were taken by the patient, but infections may also be occasional triggers 4–7 . Patch testing is often positive in AGEP with confirmation of the culprit drug; however, it can cause recurrence of the skin eruption 8 …”