Acute generalized exanthematous pustulosis induced by gliclazide: a case report

Contreras-Steyls, Marisol; Vílchez-Márquez, F.; Mota, Ana Luísa; Moyano, Blanca; Herrera‐Ceballos, Enrique

doi:10.1111/j.1365-4632.2012.05521.x

Cited by 11 publications

(5 citation statements)

References 8 publications

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“…Clavulanic acid can also induce acute systemic erythematous impetigo [13]. Other drugs have been reported to be associated with AGEP, such as acetylsalicylic acid, ibuprofen, gliclazide, acarbose, and prednisolone [14][15][16][17][18]. Te determination of amoxicillin as the primary cause of AGEP is based on the timing of the onset of AGEP and the sequence of medications taken, as well as the improvement of symptoms after withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP

Lei,

Fan,

et al. 2024

Dermatologic Therapy

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Background. Amoxicillin was associated with acute generalized exanthematous pustulosis (AGEP), and the clinical characteristics were not clear. The purpose of this study was to explore the clinical characteristics of amoxicillin-induced AGEP and to provide a basis for prevention and treatment. Methods. Case reports and case series of amoxicillin-induced AGEP were collected for retrospective analysis by searching the Chinese and English databases from inception to January 31, 2023. Results. A total of 46 patients were included with a median age of 40 years (range 1.4, 87). The onset time of AGEP ranged from 6 hours to 28 days, with a median of 2.5 days. Fever occurred in 32 patients (69.6%), and pruritus occurred in 13 patients (28.3%). Ten patients (21.7%) had mucous membrane involvement and systemic involvement, respectively. Twenty-two patients had elevated neutrophils, with a median of 12850/mm3 (range 7880, 29140). Skin biopsy mainly showed subcorneal pustules (22 cases, 47.8%), spongy pustules (14 cases, 30.4%), and inflammatory cell infiltration (26 cases, 56.5%). Skin lesions disappeared in a median of 10 days (range 2, 42) after discontinuation of amoxicillin and administration of topical steroids (26 cases, 56.5%) as well as systemic corticosteroids (13 cases, 28.3%). Conclusions. AGEP is a rare complication of amoxicillin and is self-limiting. Clinicians should correctly identify AGEP and should avoid represcribing amoxicillin. Clinicians should correctly identify AGEP and avoid represcribing amoxicillin, which can prevent unnecessary treatment measures.

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Section: Discussionmentioning

confidence: 99%

Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP

Lei,

Fan,

et al. 2024

Dermatologic Therapy

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“…Whether the mechanism of this PNS-induced skin reaction is related to drug-specific T-cells and interleukin-8 needs further investigation. AGEP or pustular drug eruption can be induced by drugs other than antibiotics, including hydroxychloroquine,5,7 sorafenib,8,9 acetazolamide,10 gliclazide,11 recombinant interleukin-2,12 and ibuprofen 13. However, there are no reports in the literature on pustular drug eruption due to traditional Chinese medicine, including PNS.…”

Section: Discussionmentioning

confidence: 99%

Pustular drug eruption due to Panax notoginseng saponins

Yin¹,

Ma²,

Xu³

et al. 2014

DDDT

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Panax notoginseng saponins (PNS) are a patented product in the People’s Republic of China, and have extensive effects on the cardiovascular system. Here we report on four elderly patients (one male and three female) with drug eruption induced by PNS injection. All developed a sudden skin rash with pruritus from head to foot, and subsequently accepted hospitalization. In each case, PNS had been used for less than 1 week before appearance of the rash. No specific short-term medications or changes in diet or exposure to environmental factors immediately prior to appearance of the rash were identified. These four patients had some interesting features in common, ie, pustules, fever, and elevated circulating neutrophil counts, which required high-dose, long-term glucocorticoid therapy. To our knowledge, this is the first report of pustular drug eruption induced by PNS and provides a useful reference and warning for clinicians.

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“…AGEP's diagnostic criteria include; a) sudden onset of numerous non-follicular pustules on widespread erythema, b) typical histopathologic changes, c) fever above 38 o C, d) neutrophilia, e) acute evolution with spontaneous resolution in 15 days [6].…”

Section: Discussionmentioning

confidence: 99%

Metamizole Associated Acute Generalized Exanthematous Pustulosis

2016

J turk acad dermatol

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Observation: Acute generalized exanthematous pustulosis is a rare and severe cutaneous reaction generally triggered by drug intake. Metamizole is a frequently used drug as an analgesic and antipyretic all over the world. Although it's widely usage there are only a few report about metamizole associated acute generalized exanthematous pustulosis. Herein we present a 49-yearold man with AGEP due to metamizol.

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Acute generalized exanthematous pustulosis induced by gliclazide: a case report

Cited by 11 publications

References 8 publications

Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP

Clinical Characteristics, Treatment, and Prognosis of Amoxicillin-Induced AGEP/ALEP

Pustular drug eruption due to Panax notoginseng saponins

Metamizole Associated Acute Generalized Exanthematous Pustulosis

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