Acute Generalized Exanthematous Pustulosis Induced by Topical Lindane

Juan, Wei-Hsin; Yang, Lan-Yan; Hong, Hong‐Shang

doi:10.1159/000079899

Cited by 14 publications

(4 citation statements)

References 13 publications

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“…There were three cases of shortness of breath, all of which followed labeled usage of lindane, two of these also involved visual changes (18), and the other was an anaphylactic reaction following labeled usage of lindane shampoo (15). Of the three other reactions, there was one case of aplastic anemia (19); one case of leukocytosis, tachycardia, and alopecia (15); and one case of acute generalized exanthematous pustulosis (8).…”

Section: Resultsmentioning

confidence: 99%

“…The US Food and Drug Administration (FDA) (7) recognized the need for better patient education of the use of lindane and required, in 2003, that a Medication Guide be dispensed with every lindane prescription in addition to the package insert. Cases of adverse events with lindane and inappropriate use continued in spite of this added safety measure (8). In December 2007, the FDA sent a warning letter to Morton Grove Pharmaceuticals, the US manufacturer of lindane products.…”

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confidence: 99%

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Lindane Toxicity: A Comprehensive Review of the Medical Literature

Nolan

Kamrath

Levitt

2011

Pediatric Dermatology

109

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Lindane is an organochloride pesticide, first introduced as a scabicide for human use in the 1950s. Because of its low cost and efficacy, it quickly became a first-line treatment for scabies and head lice, but not long after its use became widespread, its safety was called into question, primarily regarding its neurotoxic effects. We intend to show through review of the literature and databases that lindane has been associated with numerous severe and fatal adverse reactions. This review will summarize 67 cases of adverse reactions and deaths associated with the medical use of lindane. Many of the most serious events and fatalities occurred in pediatric and geriatric populations. We concede that toxicity frequently arises from misuse, but labeled usage of lindane caused 43% of the serious adverse reactions of this review. Moreover, the numerous instances of lindane misuse elucidate the importance of clear labeling and instructions, especially with a product with a narrow therapeutic index. Therefore, this report attempts to elucidate the dangers of lindane as a medical treatment for scabies and head lice by providing a comprehensive review of all documented adverse drug reactions since its introduction.

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Section: Resultsmentioning

confidence: 99%

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confidence: 99%

Lindane Toxicity: A Comprehensive Review of the Medical Literature

Nolan

Kamrath

Levitt

2011

Pediatric Dermatology

109

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“…Anti-infective drugs and in particular beta-lactam antibiotics as well as a wide variety of other systemic drugs and rarely also topical products such as mercury and lindane (γ-benzene hexachloride) are recognized as causative agents [7, 11, 12]. Quinolone-induced cases are rare and only 4 cases have been described so far including this report [4,5,6].…”

Section: Discussionmentioning

confidence: 99%

Ciprofloxacin-Induced Acute Generalized Exanthematous Pustulosis Mimicking Bullous Drug Eruption Confirmed by a Positive Patch Test

Häusermann¹,

Scherer

Weber³

et al. 2005

Dermatology

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We report the case of an 80-year-old woman presenting with ciprofloxacin-induced acute generalized exanthematous pustulosis (AGEP) confirmed by a positive patch test. Cutaneous morphology, course and histological findings were consistent with a definite diagnosis according to the AGEP validation score of the EuroSCAR study group. We point to the rarity of quinolone-induced AGEP and discuss immunological mechanisms, the value of in vivo and in vitro tests as well as the main differential diagnosis. Furthermore, we highlight in this particular case the challenging differentiation from bullous drug eruption.

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“…Association with systemic drugs was still the most common aetiology (10 of 16 patients), especially antibiotics, although significantly lower than previously reported (2) (62.5% vs. 87%, p < 0.05, χ 2 test). Among the rest of patients, one had contact history with scabicide (8), one had no contributory causes, and 4 had a history of recent infection.…”

Section: Clinical Manifestations and Characteristics Of Patients With...mentioning

confidence: 99%

Clinical Manifestations and Characteristics of Patients with Acute Generalized Exanthematous Pustulosis in Asia

Chang

Huang²,

Yang³

et al. 2008

Acta Derm Venereol

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Acute generalized exanthematous pustulosis is a rare, sterile inflammation of the skin (and mucous membranes) characterized by acute onset of generalized pustule formation, fever and leukocytosis, and a rapid resolution. A computer-based search of the literature revealed only a limited series of reports, none of them based on Asian patients. We identified and retrospectively analysed 16 biopsy-proven and criteria-matched patients over a 15-year period in a single medical centre. The study showed a female predominance (11 of 16 patients), a relatively low association with systemic drugs (62.5% vs. 87% in a previous report) and normal renal function (in contrast to a previous report where 32% of patients had renal failure). The study also revealed high levels of C-reactive protein (76.0 mg/l) and normal absolute eosinophil count (176.2/microl) in most patients. Furthermore, there was no difference between different treatment regimens regard-ing the course and duration of the disease or the length of fever (p>0.05). In addition, if the patients were subdivided by aetiology into those strongly associated with or not strongly associated with systemic drugs, a significant difference was found in age of onset between the 2 groups (p

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Acute Generalized Exanthematous Pustulosis Induced by Topical Lindane

Cited by 14 publications

References 13 publications

Lindane Toxicity: A Comprehensive Review of the Medical Literature

Lindane Toxicity: A Comprehensive Review of the Medical Literature

Ciprofloxacin-Induced Acute Generalized Exanthematous Pustulosis Mimicking Bullous Drug Eruption Confirmed by a Positive Patch Test

Clinical Manifestations and Characteristics of Patients with Acute Generalized Exanthematous Pustulosis in Asia

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