Acute generalized exanthematous pustulosis induced by celecoxib

Acute generalized exanthematous pustulosis associated with ipilimumab and nivolumab

“…2 Anti-Programmed Death-1 (PD-1) therapies recently showed their efficacy in several types of tumour, especially in patients with recurrent or metastatic head and neck squamous cell carcinomas that has continued to progress despite standard of care treatment, suggesting the potential efficacy of anti-PD1 in CSCC. 3,4 Here, we report two cases of CSCC responding to anti-PD1 antibodies.…”

“…2 Thus, prompt diagnosis and discontinuation of the drug are very important to prevent further complications. 3 We report a 46-year-old man who had a history of malignant melanoma with cerebral, pulmonary and mediastinal metastases. He was given four cycles of ipilimumab in combination with nivolumab during 2 months.…”