Acute generalized exanthematous pustulosis (<scp>AGEP</scp>) induced by azithromycin

Campanón-Toro, M V; Sierra, Omar; Moreno, Esther; Sobrino‐García, Miriam; Bara, María Teresa Gracia; Dávila, Ignacio

doi:10.1111/cod.12717

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…The patient was diagnosed with AGEP by skin biopsy and treated with symptomatic medications (topic clobetasol and loratadine once daily). As expected, the pustulosis cleared within 15 days from suspension of the azithromycin [13].…”

Section: Discussionsupporting

confidence: 79%

Acute Generalized Exanthematous Pustulosis during Puerperal Period Induced by Azithromycin: Case Report

Vettorazzi¹,

Valério²,

Kayser³

et al. 2018

OJOG

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Background: The use of antibiotics, especially beta-lactams and macrolides, may be associated with dermatopathies, such as Acute Generalized Exanthematous Pustulosis (AGEP), which is an uncommon cutaneous adverse reaction. Case: We report a case of AGEP, in a 36-year-old multiparous (G5P3C1A1) woman, with 38 weeks of gestation, admitted to the hospital to induce labor. Due to cephalopelvic disproportion, the cesarean section was indicated. In the postoperative period, the patient evolved with cutaneous rash, accompanied by productive cough and dyspnea. Because it was a fever of obscure origin, the treatment with antibiotics, including azithromycin, was initiated. On subsequent days, she presented pustules on the back, abdomen and extremities. Such reaction was attributed to the use of azithromycin. When the drug was discontinued, the lesions regressed significantly. Conclusion: The clinical picture of AGEP may occur with persistent high fever and therefore could be confused with systemic infections, consequently, being treated with wrong medications capable of aggravating the adverse cutaneous reaction, worsening the course of the disease that could be easily treated by stopping the use of the causative drug. This case shows the importance of including AGEP as a differential diagnosis of dermatopathies in the pregnancy-puerperal cycle, especially in women who are using various medications, including antibiotics.

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Section: Discussionsupporting

confidence: 79%

Acute Generalized Exanthematous Pustulosis during Puerperal Period Induced by Azithromycin: Case Report

Vettorazzi¹,

Valério²,

Kayser³

et al. 2018

OJOG

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“…Azithromycin has been implicated in contact dermatitis in occupational 75 and nonoccupational settings 76 . Cases of fixed drug eruption (FDE), 77 AGEP, 78 and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS), 79 SJS, 80,81 leukocytoclastic vasculitis, 82 and hypersensitivity myocarditis 83 were reported(Table 2).…”

Section: Antiviral And/or Immunomodulatory Drugs Used For Viral Pneummentioning

confidence: 99%

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Gelincik

Brockow

Çelik

et al. 2020

Allergy

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Coronavirus disease 2019 (COVID‐19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID‐19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off‐label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings together all the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off‐label drugs and highlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactions in the course of the disease.

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“…Azithromycin has been implicated in contact dermatitis in occupational (72) and non-occupational settings (73). Cases of fixed drug eruption (FDE) (74), AGEP (75) and Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) (76), SJS (77,78), leukocytoclastic vasculitis (79), and hypersensitivity myocarditis (80) were reported.…”

Section: Hypersensitivity Reactionsmentioning

confidence: 99%

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19

Gelincik

Brockow

Çelik

et al. 2020

Preprint

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID-19), a respiratory tract infection caused by a novel human coronavirus, the severe acute respiratory syndrome coronavirus 2, leads to a wide spectrum of clinical manifestations ranging from asymptomatic cases to patients with mild and severe symptoms, with or without pneumonia. Given the huge influence caused by the overwhelming COVID-19 pandemic affecting over three million people worldwide, a wide spectrum of drugs is considered for the treatment in the concept of repurposing and off-label use. There is no knowledge about the diagnosis and clinical management of the drug hypersensitivity reactions that can potentially occur during the disease. This review brings together all the published information about the diagnosis and management of drug hypersensitivity reactions due to current and candidate off-label drugs and highlights relevant recommendations. Furthermore, it gathers all the dermatologic manifestations reported during the disease for guiding the clinicians to establish a better differential diagnosis of drug hypersensitivity reactions in the course of the disease.

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Acute generalized exanthematous pustulosis (AGEP) induced by azithromycin

Cited by 7 publications

References 5 publications

Acute Generalized Exanthematous Pustulosis during Puerperal Period Induced by Azithromycin: Case Report

Acute Generalized Exanthematous Pustulosis during Puerperal Period Induced by Azithromycin: Case Report

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19: An EAACI Position Paper

Diagnosis and management of the drug hypersensitivity reactions in Coronavirus disease 19

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