Acute Generalized Exanthematous Pustulosis With Cytomegalovirus Infection

Allopurinol Hypersensitivity Syndrome Associated with Systemic Cytomegalovirus Infection and Systemic Bacteremia.

“…Although the initial eruption decreased following the initiation of prednisolone therapy, a newrash appeared and developed into toxic epidermal necrosis. Wespeculated that the newrash might have been induced by CMVinfection (17). If this was true, treatment with ganciclovir and tapering of the treatment with prednisolone should have been started as soon as possible.…”

Do the Physical and Histologic Features and Time Course in Acute Generalized Exanthematous Pustulosis Reflect a Pattern of Cytokine Dysregulation?

“…Although AGEP is usually reported with drugs used to treat known or suspected underlying infections, it has also been associated with viral infections without therapy, to an ever wider spectrum of other classes of drugs in patients without associated infections, to dietary supplements, after exposure to mercury, and after radiation. [1][2][3][4][5][6][7][8][9][10][11][12][13][14] Antibiotics are the most common medications associated with these eruptions, usually in patients with underlying infections. 1,12 This is also the case in the patients in our study; however, antifungal medications were implicated in approximately 25% of our patients.…”

Severe Cutaneous Adverse Reactions

“…The role of infectious agents in AGEP has been suggested in various case reports due to the absence of an inciting drug [231]. The organisms include coxsackie B4 [232], cytomegalovirus [233], parvovirus B19 [234], Chlamydia pneumoniae [235], and Escherichia coli [236]. No significant risk for infection was found in the EuroScar study although the study was not designed to identify potential causative organisms.…”