Acute glomerulonephritis in Trinidad: serological typing of group A streptococci

Parker, M. T.; Bassett, D. C. J.; Maxted, W. R.; Arneaud, J. D.

doi:10.1017/s0022172400028394

Cited by 39 publications

(19 citation statements)

References 19 publications

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“…They appear to be of moderate virulence and non-nephritogenic, and to have little if any affinity for respiratory tissues. While Parker found that in a series of patients there tended to be a sequence of streptococcal types during the course of their illness (Parker et al 1968), our cases were remarkable for the purity and consistency of their culture isolates during an episode of infection. A further unusual feature is the long-term presence of the two strains in almost unchanged proportions in the affected population.…”

Section: Discussionmentioning

confidence: 53%

A large outbreak of streptococcal pyoderma in a military training establishment

Cruickshank

Lightfoot

Sugars

et al. 1982

J. Hyg.

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SUMMARYAn outbreak of streptococcal pyoderma in a military institution into which fresh susceptible recruits were regularly introduced involved more than 1300 persons over an eighteen-month period. Two M types were responsible for the great majority of the cases and an attack by one conferred immunity to that strain but not to the other. Lesions varied from trivial to disabling. Epidemiological studies indicated that contact -direct or indirect -through such things as gymnasium equipment and room dust was the means of transmission. The outbreak was eventually controlled by vigorous case finding, thorough treatment of cases and the strict application of hygienic principles to prevent spread. There were no late complications and throat streptococci were not involved. It is possible to control such an outbreak without isolation or the making of any significant concessions in the training programme even when large numbers of persons are living and working at close quarters.

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Section: Discussionmentioning

confidence: 53%

A large outbreak of streptococcal pyoderma in a military training establishment

Cruickshank

Lightfoot

Sugars

et al. 1982

J. Hyg.

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“…Neither M-type 57 strains nor antibodies (with one exception) were found before that time, while both were present subsequently. This type also nearly disappeared as T-type 4 The highest titers of type-specific antibody were obtained in the tests for M-type 55 antibody in 1965. Several BI's were well over 100.…”

Section: Resultsmentioning

confidence: 88%

“…M-type 49 strains also have been identified in our laboratory from two boys who had acquired skin lesions in Puerto Rico and developed nephritis following their return to Chicago, from skin lesions on a child with nephritis in the Panama Canal Zone, and from the sibling of a young patient with acute nephritis in Chicago. Identification of this type in 38% of the strains from nephritic patients in Trinidad, compared with 15% of the strains from school children (4) indicates its importance in the second wave of the 1965 epidemic. Failure to find M-type 49 antibodies in more than 17% of patients ill at that time may have resulted from factors affecting antibody response (vide infra) rather than to absence of infection with this streptococcal type.…”

Section: Resultsmentioning

confidence: 96%

“…This epidemic was biphasic with peak incidences in January and September which were associated with two respective M types of streptococci (2)(3)(4). After the epidemic, long-term surveillance studies of streptococcal infections and nephritis were established in Trinidad which document the occurrence of an additional biphasic epidemic in [1967][1968], involving 540 cases of acute glomerulonephritis.…”

Section: Introductionmentioning

confidence: 99%

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Changing types of nephritogenic streptococci in Trinidad

Potter¹,

Ortiz²,

Sharrett³

et al. 1971

J. Clin. Invest.

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A B STRA CT The relation of seven different M types of streptococci to acute glomerulonephritis associated with skin lesions in South Trinidad has been studied by means of type-specific antibody assays as well as by isolation and identification of the strains. The data indicate that, one after another, five of these strains have prevailed among patients with acute glomerulonephritis during the past five years. At least three of the strains (M-types 55, 49, 57, and/or 60) were associated with epidemic increases in nephritis cases. The appearance of five consecutively predominant types of nephritogenic streptococci during a relatively short period of time is in contrast to the continuing prevalence of M-type 12 strains among nephritogenic streptococci primarily associated with respiratory infections in temperate zones. These observations suggest that the skin sores commonly found on children in tropical Trinidad, provide a particularly suitable environment for development of nephritogenic types. It remains to be seen whether these types will recur or whether new types will continue to emerge in Trinidad.

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“…' Other groups of streptococci were not commonly isolated from lesions: Group G in four instances, Groups B and C in none. (2,3,9,19,20). In Fig.…”

Section: Methodsmentioning

confidence: 99%