Acute Glucocorticoids Interact with Arousal State in Regulating Long‐term Memory Formation

Campolongo, Patrizia; Roozendaal, Benno

doi:10.1002/9781118083222.ch9

Cited by 2 publications

(3 citation statements)

References 122 publications

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“…In the present study, Synacthen injection promoted an increased brain activity in chronically stressed animals, during the neutral olfactory stimulation with the vehicle, notably in the hippocampus and in regions involved in sensory perception and arousal. It is well documented that glucocorticoids interact with the arousal state [49] and that their signaling, notably in the hippocampus, amygdala and DL-PFC, play a critical role in encoding, processing, and retaining emotional and stressful events [50]. Consolidating such memory is an adaptive response that might be necessary for appropriate reactions to further similar situations [50].…”

Section: Pharmacological Acute Stress Increased the Brain Activity Inmentioning

confidence: 99%

Regular exposure to a Citrus-based sensory functional food ingredient alleviates the BOLD brain responses to acute pharmacological stress in a pig model of psychosocial chronic stress

Menneson

Serrand²,

Janvier³

et al. 2020

PLoS ONE

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Psychosocial chronic stress is a critical risk factor for the development of mood disorders. However, little is known about the consequences of acute stress in the context of chronic stress, and about the related brain responses. In the present study we examined the physio-behavioural effects of a supplementation with a sensory functional food ingredient (FI) containing Citrus sinensis extract (D11399, Phodé, France) in a pig psychosocial chronic stress model. Female pigs underwent a 5- to 6-week stress protocol while receiving daily the FI (FI, n = 10) or a placebo (Sham, n = 10). We performed pharmacological magnetic resonance imaging (phMRI) to study the brain responses to an acute stress (injection of Synacthen®, a synthetic ACTH-related agonist) and to the FI odour with or without previous chronic supplementation. The olfactory stimulation with the ingredient elicited higher brain responses in FI animals, demonstrating memory retrieval and habituation to the odour. Pharmacological stress with Synacthen injection resulted in an increased activity in several brain regions associated with arousal, associative learning (hippocampus) and cognition (cingulate cortex) in chronically stressed animals. This highlighted the specific impact of acute stress on the brain. These responses were alleviated in animals previously supplemented by the FI during the entire chronic stress exposure. As chronic stress establishes upon the accumulation of acute stress events, any attenuation of the brain responses to acute stress can be interpreted as a beneficial effect, suggesting that FI could be a viable treatment to help individuals coping with repeated stressful events and eventually to reduce chronic stress. This study provides additional evidence on the potential benefits of this FI, of which the long-term consequences in terms of behaviour and physiology need to be further investigated.

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Section: Pharmacological Acute Stress Increased the Brain Activity Inmentioning

confidence: 99%

Regular exposure to a Citrus-based sensory functional food ingredient alleviates the BOLD brain responses to acute pharmacological stress in a pig model of psychosocial chronic stress

Menneson

Serrand²,

Janvier³

et al. 2020

PLoS ONE

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“…Hormonal responses to an emotional experience regulate memory for that experience (e.g., Gold and McGaugh, 1975; Gold, 1992; Cahill and McGaugh, 1998; Korol and Gold, 2007, 2008; de Quervain et al, 2009; Gold and Korol, 2010; Schwabe et al, 2012; Campolongo and Roozendaal, 2011; Sandi, 2011). The hormonal regulators of memory include adrenal, gonadal, and stress steroids as well as adrenal catecholamines.…”

Section: Introductionmentioning

confidence: 99%

“…Of these, glucocorticoids and epinephrine respond acutely to the emotional context of an experience and appear to regulate both the strength and quality of emotional memories. Glucocorticoids have received the most attention in this respect, as noted by several recent reviews of the steroid’s effects on memory (e.g., Campolongo and Roozendaal, 2011; Schwabe et al, 2010, 2012; Sandi, 2011). Of note, the effects of glucocorticoids and epinephrine on memory appear to have several points of convergence.…”

Section: Introductionmentioning

confidence: 99%

Making Memories Matter

Gold¹,

Korol²

2012

Front. Integr. Neurosci.

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This article reviews some of the neuroendocrine bases by which emotional events regulate brain mechanisms of learning and memory. In laboratory rodents, there is extensive evidence that epinephrine influences memory processing through an inverted-U relationship, at which moderate levels enhance and high levels impair memory. These effects are, in large part, mediated by increases in blood glucose levels subsequent to epinephrine release, which then provide support for the brain processes engaged by learning and memory. These brain processes include augmentation of neurotransmitter release and of energy metabolism, the latter apparently including a key role for astrocytic glycogen. In addition to up- and down-regulation of learning and memory in general, physiological concomitants of emotion and arousal can also switch the neural system that controls learning at a particular time, at once improving some attributes of learning and impairing others in a manner that results in a change in the strategy used to solve a problem.

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Acute Glucocorticoids Interact with Arousal State in Regulating Long‐term Memory Formation

Cited by 2 publications

References 122 publications

Regular exposure to a Citrus-based sensory functional food ingredient alleviates the BOLD brain responses to acute pharmacological stress in a pig model of psychosocial chronic stress

Regular exposure to a Citrus-based sensory functional food ingredient alleviates the BOLD brain responses to acute pharmacological stress in a pig model of psychosocial chronic stress

Making Memories Matter

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