Acute Glycemic Control in Prediabetes Individuals Favorably Alters Serum NLRP3 Inflammasome and Related Interleukins

Alfadul, Hend; Sabico, Shaun; Alnaami, Abdullah M.; Amer, Osama E.; Hussain, Syed D.; Wani, Kaiser; Clerici, Mario; Al-Daghri, Nasser M.

doi:10.3390/ijms241813837

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…IL-33 serum levels were measured using available commercial ELISA kit (BioVendor, R&D systems, Brno, Czech Republic) Cat No. RAF064R [61,62]. According to the manufacturer, intra-assay and inter-assay % CV were less than 4.7% and less than 6.9%, respectively.…”

Section: Anthropometrics and Biochemical Analysesmentioning

confidence: 97%

Circulating Interleukins-33 and -37 and Their Associations with Metabolic Syndrome in Arab Adults

Amer,

Sabico,

Khattak

et al. 2024

IJMS

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Interleukins (ILs) are a group of cytokines known to have immunomodulatory effects; they include ILs–33 and –37 whose emerging roles in the pathogenesis of metabolic syndrome (MetS) remain under investigated. In this study, we compared circulating IL–33 and IL–37 in Arab adults with and without MetS to determine its associations with MetS components. A total of 417 Saudi participants (151 males, 266 females; mean age ± SD 41.3 ± 9.0 years; mean body mass index ± SD 30.7 ± 6.3 kg/m2) were enrolled and screened for MetS using the ATP III criteria. Anthropometrics and fasting blood samples were taken for the assessment of fasting glucose and lipids. Circulating levels of IL–33 and IL–37 were measured using commercially available assays. The results showed higher levels of serum IL–33 and IL–37 in participants with MetS than those without (IL-33, 3.34 3.42 (2.3–3.9) vs. (1–3.9), p = 0.057; IL-37, 5.1 (2.2–8.3) vs. 2.9 (2.1–6.1), p = 0.01). Additionally, having elevated levels of IL–33 was a risk factor for hypertension, low HDL-c, and hypertriglyceridemia. A stratification of the participants according to sex showed that males had higher IL-33 levels than females [3.7 (3.0–4.1) vs. 3.15 (1.4–3.8), p < 0.001], while females had higher levels of IL–37 than males [3.01 (2.2–7.0) vs. 2.9 (2.1–5.6), p = 0.06]. In conclusion, the presence of MetS substantially alters the expression of ILs–33 and -37. IL-33 in particular can be potentially used as a therapeutic target to prevent MetS progression. Longitudinal and interventional studies are warranted to confirm present findings.

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Section: Anthropometrics and Biochemical Analysesmentioning

confidence: 97%

Circulating Interleukins-33 and -37 and Their Associations with Metabolic Syndrome in Arab Adults

Amer,

Sabico,

Khattak

et al. 2024

IJMS

Self Cite

View full text Add to dashboard Cite

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Trends and characteristics of the metabolically healthy obese phenotype in an Arab population

Wani,

Kumar,

Al-Daghri

et al. 2024

Front. Public Health

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The metabolically healthy obesity (MHO) phenotype represents a complex and distinctive trait, the trends and characteristics of which remain unknown in the Saudi Arabian adult population. The present study aims to fill that gap. A combined total of 10,220 Saudi adults from 2 independent cohorts [2008–2019, N = 7,896 (2,903 males and 4,993 females), and 2021–2023, N = 2,324 (830 males and 1,494 females)] aged 19–70 years old was screened, of whom 9,631 (3,428 males and 6,203 females) were included. Anthropometric data were measured, and fasting blood samples were collected to assess glucose, lipids, adipocytokines and inflammatory markers using routine methods and commercially available assays. Obesity was defined as a body mass index (BMI) ≥30 kg/m2. Screening for MHO was done using the empiric definition proposed by Zembic and colleagues and the by the National Cholesterol Education Program’s Adult Treatment Panel III (NCEP ATPIII). Of the 3,949 (41.0%) participants with obesity, 33.4% (95% confidence interval, CI, 32–35) were considered MHO using the empiric definition, and 32.8% (95% CI, 31–34) using NCEP-ATPIII. The overall age and gender adjusted prevalence of MHO in the Saudi adult population was 31.6% (95% CI, 30–33) and 30.1% (29–31) by the two definitions, respectively. Females had a higher age-adjusted prevalence of MHO than males (OR = 1.22, 95% CI 1.1–1.4, p = 0.009) as per the ATPIII criteria. MHO prevalence substantially increased over time from 2008 to 2023 (p < 0.001) for both definitions. Circulating leptin levels and insulin resistance were significantly higher in the MUO group than the MHO group independent of the definition used, suggesting the presence of a more severe form of leptin resistance in the MUO group which may explain the worse cardiometabolic profile as compared to the MHO group. In summary, the study highlights the first time the characteristics and trends of the MHO phenotype among Saudi Arabian adults. The pluripotent effects of leptin and its resistance may be central to MHO’s progression, or lack thereof, to the MUO phenotype, and this needs further investigation.

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Acute Glycemic Control in Prediabetes Individuals Favorably Alters Serum NLRP3 Inflammasome and Related Interleukins

Cited by 2 publications

References 54 publications

Circulating Interleukins-33 and -37 and Their Associations with Metabolic Syndrome in Arab Adults

Circulating Interleukins-33 and -37 and Their Associations with Metabolic Syndrome in Arab Adults

Trends and characteristics of the metabolically healthy obese phenotype in an Arab population

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