Acute Haemorrhagic Oedema of the Skin in Infancy

Taı̈eb, Alain; Legrain, V.

doi:10.1002/9781444345384.ch161

Cited by 8 publications

(13 citation statements)

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“…It is considered to be an immune complex‐mediated vasculitis and mostly affects infants between 4 months and 2 years of age (5). The aetiology is obscure, although it has been suggested that bacterial and viral infections (mainly of the upper respiratory and urinary tracts) contribute to the development of AHEI (6). The differential diagnosis includes urticarial vasculitis, Kawasaki disease, erythema multiforme, Sweet’s syndrome and Gianotti‐Crosti disease (7).…”

Section: The Case Presentation Can Be Found On Page 1390 Discussionmentioning

confidence: 99%

Infant with tender oedema and purpuric lesions (Discussion and Diagnosis)

Both

Versteeg

et al. 2009

Acta Paediatrica

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Section: The Case Presentation Can Be Found On Page 1390 Discussionmentioning

confidence: 99%

Infant with tender oedema and purpuric lesions (Discussion and Diagnosis)

Both

Versteeg

et al. 2009

Acta Paediatrica

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“…AHO of the skin was first described in an infant by Snow 1 in 1913, and useful reviews have been published recently 2–4 . The majority (80%) of cases occur in children aged < 2 years, and the condition has become known as ‘acute haemorrhagic oedema of infancy’, but cases have been reported in children up to the age of 60 months 3 …”

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confidence: 99%

“…Histology often, but not exclusively, shows leucocytoclastic vasculitis involving the small blood vessels of the dermis. Perivascular IgA deposits have been identified in about 30% of cases 4 …”

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confidence: 99%

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Acute haemorrhagic oedema in a 5-year-old boy

Smith¹,

Highet²

2012

Clinical and Experimental Dermatology

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Acute haemorrhagic oedema (AHO) of the skin usually occurs in infancy, but it may occur in older children. We report the case of a 5-year-old boy with AHO, to illustrate that the condition can occur in older children.A 5-year-old boy presented with a 2-week history of an eruption appearing shortly after a mild upper respiratory infection. Tender oedema, particularly of the hands and feet, had developed, which was already settling spontaneously by presentation. He was otherwise well, and had no relevant history or allergies.On physical examination, he had widespread, sizable circular areas of slightly swollen erythema, some of which had evolved into a bruise-like appearance (Fig. 1a). Within the preceding few days, he had developed a bright red discoloration of the scrotum, with associated oedema of the penis (Fig. 1b). He was apyrexial and there was a remarkable lack of symptoms, given the extent and apparent severity of the eruption. Urinalysis excluded haematuria or proteinuria. Routine blood parameters, including inflammatory markers, were within normal limits. No histology was performed. After 1 week the lesion on the scrotum had resolved spontaneously, and no new lesions developed. The other lesions settled within 3 weeks. This episode was considered to be characteristic of AHO.AHO of the skin was first described in an infant by Snow 1 in 1913, and useful reviews have been published recently. [2][3][4] The majority (80%) of cases occur in children aged < 2 years, and the condition has become known as 'acute haemorrhagic oedema of infancy', but cases have been reported in children up to the age of 60 months. 3 The typical presentation is with sizable lesions (up to a few centimetres in diameter) of inflammatory oedema and ecchymotic purpura, mainly of the limbs and face. Some lesions may be targetoid. In boys, scrotal lesions are common. In around three-quarters of patients, there is a history of a preceding respiratory infection, medication use or immunization. A striking feature is the contrast between the severity of the cutaneous findings and the general good health of the child. Involvement of C P D Figure 1 (a) Widespread sizable circular areas of slightly swollen erythema, some of which had evolved into a bruise-like appearance; (b) bright-red discoloration of the scrotum with associated oedema of the penis. CED Clinical and Experimental Dermatology

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“…It was first described by Snow as a purely cutaneous variant of Henoch‐Schönlein purpura (1,2). Infants present with mild fever, edema of the face and extremities, erithemateous and purpuric lesions without systemic symptoms (1,3). Treatment is unnecessary.…”

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confidence: 99%