Acute heart failure related to a large left atrial myxoma

Chiariello, Giovanni Alfonso; Bruno, Piergiorgio; Colizzi, Christian; Pavone, Natalia; Nesta, Marialisa; Cammertoni, Federico; Mazza, Andrea; Posteraro, Alfredo; Perri, Gianluigi; Massetti, Massimo

doi:10.1080/08998280.2018.1446641

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…About 80% of patients manifest dyspnoea, palpitations, syncope, ankle oedema, and chest pain; acute heart failure in patients with atrial myxoma has rarely been described. 10 A 30% of tumours in this location manifest some embolic event. 6 , 11…”

Section: Discussionmentioning

confidence: 99%

Acute heart failure due to a giant left atrial myxoma: a case report

Alan

Andres

Antonio

2022

European Heart Journal - Case Reports

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Background Cardiac myxomas are the most common primary benign tumor of the heart. Most of them occur between the 4th and 6th decade of life, are most frequent in the woman, and most frequently localized in the left atrium Case summary We present a case of a 41-year-old female who presented with a history of left-sided heart failure. A left atrial mass of 87 × 88 × 65 mm was documented by cardiac magnetic resonance. She was taken to surgical resection of the mass. Histopathologic findings were diagnostic of cardiac myxoma. Generally, myxomas that are bigger than 6 cm are associated with the worst prognosis. Discussion Primary cardiac tumors are mostly benign, being in 50% of the cases a cardiac myxoma. The rest of them correspond to papillary fibroelastoma (26%), fibromas (6%), lipomas (4%), and others including calcified tumors, hemangiomas, teratomas, cysts, and rhabdomyomas. Our clinical case illustrates an unusual and rare presentation of cardiac myxoma with a double mitral lesion.

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Section: Discussionmentioning

confidence: 99%

Acute heart failure due to a giant left atrial myxoma: a case report

Alan

Andres

Antonio

2022

European Heart Journal - Case Reports

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“…5,15 The emergence of heart failure is contingent on tumor location and burden in creating a pseudo-stenotic effect due to malapposition of mitral valve leaflets and obstructive physiology within the left ventricular outflow tract. 16 Also, it has been postulated that a paraneoplastic cytokine milieu may induce myocardial inflammation and resultant ischemia. 17,18 Coronary embolization of tumor fragments may also be implicated in the pathogenesis of incident heart failure; however, angiography was deferred in preference to a non-invasive approach.…”

Section: Discussionmentioning

confidence: 99%

Medical management of a suspected atrial myxoma in a nonagenarian

Kawall¹,

Seecheran²,

Seecheran³

et al. 2020

SAGE Open Medical Case Reports

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Cardiac myxomas are the most frequently encountered tumors of the heart. However, they are unusual to be newly diagnosed in the geriatric population. Myxomas are among the great mimickers, with a myriad of clinical presentations related to heart failure, embolic events, and constitutional symptoms. We describe a rare case of a giant atrial myxoma in a nonagenarian presenting with heart failure, which was medically managed.

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“…The development of acute heart failure, due to inadequate coaptation of the mitral valves with obstruction of the left ventricular outflow tract in diastole depends on the myxoma’s size and position. Some authors have hypothesized the release of interleukin-6 and -8 by the atrial myxoma may provoke myocardial tissue inflammation and global left ventricular dysfunction 10,11. These cytokine mechanistic effects promote the adhesion of neutrophils; and with the attachment of myxoma cells to the coronary endothelium, may be responsible for triggering myocardial ischemia and infarction at the cellular level 12,13.…”

Section: Discussionmentioning

confidence: 99%