Acute hemodynamic benefit of multisite ventricular pacing after congenital heart surgery

Zimmerman, Frank; Starr, Joanne P.; Koenig, Peter; Smith, Patricia; Hijazi, Ziyad M.; Bacha, Emile A.

doi:10.1016/s0003-4975(03)00175-9

Cited by 125 publications

(68 citation statements)

References 14 publications

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“…This is consistent with other studies, in which QRS duration during pacing was not related to cardiac function [25,36,42]. It is important to bear in mind that QRS duration reflects total biventricular activation time, whereas intraventricular mechanical synchrony and sequence of electrical ventricular activation [26] probably are more important determinants of LV function [19,36].…”

Section: Relation Between Pacing Site and LV Functionsupporting

confidence: 91%

“…Cardiac resynchronization therapy with biventricular pacing increases cardiac function after surgery for patients with congenital heart disease compared with intrinsic activation [13,42]. Experience with chronic biventricular pacing in children is sparse, but a multicenter study showed promising results with regard to cardiac function after 4 months of resynchronization therapy [11], and biventricular pacing proved effective in the treatment of six children with RV pacing-induced heart failure [20].…”

Section: Relation Between Pacing Site and LV Functionmentioning

confidence: 99%

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Chronic Left Ventricular Pacing Preserves Left Ventricular Function in Children

et al. 2008

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Chronic right ventricular (RV) pacing can induce structural and functional cardiac deterioration. Because animal studies showed a benefit of left ventricular (LV) over RV pacing, this study compared the effects of chronic RV and LV pacing in children. Retrospectively, echocardiographic data were evaluated from 18 healthy children (control subjects) and from children undergoing chronic epicardial RV pacing (7 RVP) or LV pacing (7 LVP). Assessment included LV end-diastolic wall thickness (LVEDWT) and end-systolic wall thickness (LVESWT) as well as LV end-diastolic diameter (LVEDD) and end-systolic diameter (LVESD). The shortening fraction and eccentricity index (LV diameter/2 9 LV wall thickness) were calculated as measures of LV function and eccentricity, respectively. Duration of QRS and septal posterior wall motion delay (SPWMD) were used as measures of electrical and mechanical dyssynchrony, respectively. A p value less than 0.05 determined significance. As the findings showed, LVEDD, LVESD, LVEDWT, and LVESWT were not significantly different between the groups. The shortening fraction was significantly lower in the RVP (21.7% ± 6.0%) than in the LVP (32.2% ± 5.2%) or control (29.3% ± 4.3%) children. The systolic LV eccentricity index was significantly larger in the RVP (1.8 ± 0.2) than in the LVP (1.4 ± 0.1) or control (1.4 ± 0.2) children. The SPWMD was significantly larger in the RVP (338 ± 20 ms) than in the LVP (-16 ± 14 ms) or control (-5 ± 35 ms) group, whereas QRS duration was similarly longer in the RVP (157 ± 10 ms) and LVP (158 ± 22 ms) groups compared than in the control group (69 ± 7 ms). The authors conclude that LV function in children is preserved by chronic pacing at the LV lateral wall.Keywords Cardiac function Á Children Á Dyssynchrony Á Pacing Á Site Á Ventricular In children and adults with congenital or acquired atrioventricular (AV) block, the ventricular pacing lead is traditionally positioned at the right ventricle (RV) [16,19]. However, RV apex pacing causes an acute decrease in left ventricular (LV) function in animals [26], adults [6] and children [14,36]. During chronic RV pacing in children, LV function, morphology [30,31], and histology [15] are at risk for deterioration over time (for review see Karpawich [16]). Chronic RV pacing can eventually result in cardiac failure, which occurs in 6% to 7% of children [17,20,38]. Also, in adults, chronic RV apex pacing has deleterious effects (for review see Manolis [19]) and increases the risk of heart failure [1,28].Recognition of the possible harmful effects from RV apex pacing initiated the search for alternative ventricular pacing sites including the RV outflow tract, His bundle, LV wall, and biventricular pacing. Pacing at the His bundle is likely the superior approach [8], but appears to be

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Section: Relation Between Pacing Site and LV Functionsupporting

confidence: 91%

Section: Relation Between Pacing Site and LV Functionmentioning

confidence: 99%

Chronic Left Ventricular Pacing Preserves Left Ventricular Function in Children

et al. 2008

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“…The authors concluded that temporary CRT via postoperative pacing wires is technically feasible and provides a highly useful adjunct for the treatment of postoperative ventricular dysfunction. • The use of CRT in the acute postoperative setting has also been evaluated by Zimmerman et al [18]. In this study, the acute hemodynamic effect of CRT delivered via atrial synchronous multisite ventricular pacing was assessed in 29 patients following congenital heart surgery.…”

Section: Treatmentmentioning

confidence: 98%

Cardiac resynchronization therapy in pediatrics: Emerging technologies for emerging indications

Rhee

2005

Curr Treat Options Cardio Med

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Cardiac resynchronization therapy (CRT) has become the standard of care for the treatment of heart failure in adults with decreased ventricular function and conduction delay who remain symptomatic despite optimal medical therapy. Indications for CRT in adults include medically refractory heart failure with a QRS duration of >or=120 msec and a left ventricular end-diastolic dimension of >or=55 mm with ejection fraction

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“…This strategy of multisite pacing was first evaluated by Zimmerman et al 80 and later by Bacha et al 81 in the immediate postoperative setting. Three unipolar temporary epicardial pacing leads were placed as far apart from each other on the ventricle as possible to allow simultaneous stimulation of both free walls.…”

Section: Crt For the Failing Single Ventriclementioning

confidence: 99%

Cardiac Resynchronization Therapy for Pediatric Patients With Heart Failure and Congenital Heart Disease

Motonaga

Dubin

2014

Circulation

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1879C ardiac resynchronization therapy (CRT) is an effective treatment for adult patients with left ventricular (LV) failure. Large prospective, randomized, controlled trials have demonstrated that CRT results in improvement in cardiac function, LV reverse remodeling, decreased hospitalizations for heart failure (HF), improved quality of life, and decreased overall mortality.1-5 However, 30% of adult patients are nonresponders to CRT, spurring further evaluation of electromechanical dyssynchrony to determine optimal pacing sites and to improve CRT selection criteria for maximal response. 1,6 The positive response in adult HF prompted exploration of the use of CRT in pediatric HF patients. However, the effectiveness of CRT in the pediatric population is difficult to evaluate because of the complex anatomic substrates of congenital heart disease (CHD) and scar formation from multiple cardiac surgeries with a higher proportion of right bundle-branch block (RBBB) and right ventricular (RV) failure than in the adult population. The typical adult HF scenario of an LV ejection fraction (EF) ≤35% with a left bundle-branch block (LBBB) is uncommon in children; therefore, the adult selection criteria for CRT cannot be easily translated to pediatric patients. Furthermore, a small heterogeneous pediatric patient population hinders a systematic assessment of long-term benefit from CRT. Principles of CRTIn the normal heart, ventricular electrical activation spreads through the His-Purkinje system, which has unique rapid propagation properties and widespread distribution. This allows highly coordinated electrical activation between distant regions of both ventricles, resulting in highly synchronous mechanical contraction. Given the strong relationship between electrical excitation and mechanical contraction in the myocardium, it is not surprising that abnormal electrical activation results in abnormal mechanical contraction. 7,8 During a spontaneous or pacing-induced bundle-branch block, ventricular activation spreads primarily cell to cell through the surrounding myocardium, which can be up to 4 times slower than the specialized His-Purkinje system. 9,10 This results in asynchronous electrical activation and thus asynchronous mechanical contraction in which opposing regions of the ventricular wall become out of phase with each other. Energy generated by contraction of early activated regions is dissipated by relaxation of late-activated regions, leading to decreased energy efficiency, depressed pump function, and deleterious ventricular remodeling. 11-14Approximately 25% of adults with HF exhibit a LBBB with mechanical dyssynchrony. CRT has traditionally targeted this electrical and mechanical dyssynchrony with biventricular pacing.15 By simultaneously pacing both ventricles, CRT uniformly prolongs the time to maximum contraction in each ventricle as the activation wave fronts from both ventricles merge. 16,17 This results in a more coordinated contraction pattern, more homogeneous distribution of regional loading conditions ...

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Acute hemodynamic benefit of multisite ventricular pacing after congenital heart surgery

Cited by 125 publications

References 14 publications

Chronic Left Ventricular Pacing Preserves Left Ventricular Function in Children

Chronic Left Ventricular Pacing Preserves Left Ventricular Function in Children

Cardiac resynchronization therapy in pediatrics: Emerging technologies for emerging indications

Cardiac Resynchronization Therapy for Pediatric Patients With Heart Failure and Congenital Heart Disease

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