Acute hemodynamic effects of intravenous nicardipine in patients treated chronically with propranolol for coronary artery disease

Rocha, P; Zannier, D; Baron, Bernard; Pathé, M; David, D; Kahn, J.C.

doi:10.1016/0002-9149(87)91090-3

Cited by 13 publications

(1 citation statement)

References 28 publications

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“…Intravenous nicardipine (5 mg) given to patients with coronary artery disease without heart failure, already receiving large doses of propranolol, decreased the sys-temic vascular resistance and increased cardiac output [71]. Intravenous nicardipine (5 mg) given to patients with coronary artery disease without heart failure, already receiving large doses of propranolol, decreased the sys-temic vascular resistance and increased cardiac output [71].…”

Section: Interaction and Combination Of Calcium Antagonists With ~-Admentioning

confidence: 99%

Calcium channel antagonists part IV: Side effects and contraindications drug interactions and combinations

Opie

1988

Cardiovasc Drug Ther

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With the correct selection of drug and patient, the calcium antagonists as a group can be remarkably effective at relatively low cost of serious side effects. Almost all side effects are dose related. Minor side effects include those caused by vasodilation (flushing and headaches), constipation (verapamil), and ankle edema. Serious side effects are rare and result from improper use of these agents, as when intravenous verapamil (or diltiazem) is given to patients with sinus or atrioventricular nodal depression from drugs or disease, or nifedipine to patients with aortic stenosis. The potential of a marked negative inotropic effect is usually offset by afterload reduction, especially in the case of nifedipine which actually has the most marked negative inotropic effect. Yet caution is required when even calcium antagonists, especially verapamil, are given to patients with myocardial failure unless caused by hypertensive heart disease. Drug interactions of calcium antagonists occur with other cardiovascular agents such as alpha-adrenergic blockers, beta-adrenergic blockers, digoxin, quinidine, and disopyramide. The most marked interaction with digoxin is that with verapamil, which may raise digoxin levels by over 50%. Combination therapy of calcium antagonists with beta-blockers is increasingly common, and is probably safest in the case of dihydropyridines. Other combinations being explored are those with angiotensin-converting enzyme inhibitors and diuretics.

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Section: Interaction and Combination Of Calcium Antagonists With ~-Admentioning

confidence: 99%

Calcium channel antagonists part IV: Side effects and contraindications drug interactions and combinations

Opie

1988

Cardiovasc Drug Ther

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Combination Therapy with Nicardipine and Beta‐Adrenergic Blockade for Angina Pectoris

Lambert

1992

Clinical Cardiology

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Summary: Nicardipine a second-generation dihidropyridine calcium antagonist, has been approved in oral formulation for use in the United States, and is under review for parenteral use. Nicardipine is the most vascular-selective agent of this class currently approved and should, on theoretical grounds, be ideal for combination therapy with betaadrenergic blocking agents. Studies have shown that the combination of nicardipine and beta-blocking agents offers additional efficacy over monotherapy with either agent alone. The hemodynamic profile of combination therapy appears to be especially favorable in patients with diminished left ventricular function needing therapy with agents of both classes. Adverse effects are few and may be improved compared with other agents of the dihidropyridine class.

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Side Effects and Contraindications Drug Interactions and Combinations

Opie

Coetzee

1989

Clinical Use of Calcium Channel Antagonist Drugs

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Acute hemodynamic effects of intravenous nicardipine in patients treated chronically with propranolol for coronary artery disease

Cited by 13 publications

References 28 publications

Calcium channel antagonists part IV: Side effects and contraindications drug interactions and combinations

Calcium channel antagonists part IV: Side effects and contraindications drug interactions and combinations

Combination Therapy with Nicardipine and Beta‐Adrenergic Blockade for Angina Pectoris

Side Effects and Contraindications Drug Interactions and Combinations

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