Acute Hemodynamic Effects of Piroximone (MDL 19,205) in Patients with Moderate Congestive Heart Failure: Comparison with Sodium Nitroprusside

Arbogast, R; Brandt, Christian; Fincker, J. L.; Schechter, Paul J.

doi:10.1097/00005344-198601000-00014

Cited by 21 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These hemodynamic findings correspond with the beneficial hemodynamic effects in several clinical studies, where piroximone was used in patients with moderate [13,14] and severe [15,16] congestive heart failure as well as in patients with a low output state, refracto ry to conventional therapy after cardiac sur gery [17], Considering the energy depletion, it is of particular interest whether PDE inhibitors re duce the myocardial energy demand by vaso dilation in the periphery or increase the myo cardial energy demand by inotropism. Hasenfuss et al [ 18] postulated that with cnoximone the energy-saving effect of vasodilation repre sented by a reduction of myocardial oxygen consumption is counteracted in part by the increased energy demand of the inotropic stimulation.…”

Section: Preischemic Bolus Of Phosphodiesterase Inhibitorsupporting

confidence: 80%

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart – A Second Look Including Biochemical Data

Podesser¹,

Zwölfer

Zegner³

et al. 1996

Eur Surg Res

View full text Add to dashboard Cite

In a randomized prospective experimental study on 48 adult white Elco rabbits biochemical and rhythmic changes after bolus administration of the phosphodiesterase inhibitor piroximone were investigated using a working heart model. The treatment group (n = 21) intravenously received 1 mg/kg of piroximone 15 min before thoracotomy. Twenty-three untreated hearts served as the control group. From 6 hearts of each group myocardial biopsies were taken before ischemia, 4 (2/2) hearts were excluded. Hemodynamic results of a previous study with an identical protocol were reanalyzed; a biochemical analysis of myocardial high-energy phosphates was investigated after 60 min of global ischemia and at the end of the experiments after 45 min of reperfusion. Already prior to ischemia, in the treatment group depletion of high-energy phosphates was detected. After 60 min of ischemia during early reperfusion in the treatment group ATP and creatine phosphate depletion became even more evident and increased until the end of the experiments. The incidence of reperfusion-induced arrhythmias was significantly lower in the treatment group. Consequently these results and the hemodynamic results of prior studies indicate a possible positive effect of piroximone during the early reperfusion period by optimizing hemodynamics and arrhythmias.

show abstract

Section: Preischemic Bolus Of Phosphodiesterase Inhibitorsupporting

confidence: 80%

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart – A Second Look Including Biochemical Data

Podesser¹,

Zwölfer

Zegner³

et al. 1996

Eur Surg Res

View full text Add to dashboard Cite

show abstract

“…The findings of this study suggest that posi tive hemodynamic effects of piroximone are not only due to the well-documented vasodi lative effects on the periphery [1,8,18,25]. Moreover our findings stress the direct vaso dilative influence on the coronaries expressed by the significant postischemic increase in coronary flow in the piroximone group.…”

Section: Discussionsupporting

confidence: 66%

“…The vasodilative properties on the periphery as well as the inotropic effects of piroximone are known [1,2,11,22]. Arbogast et al [18] considers the vasodilative proper ties as the most evident hemodynamic effect. Vascular smooth muscle relaxation was well documented in animal models [23,24].…”

Section: Discussionmentioning

confidence: 99%

“…Boldt et al [12,13] and Mikulasch et al [14] already reported on the beneficial effects in coronary heart disease and in weaning from cardiopulmonary bypass. In the daily routine weaning from cardiopulmo nary bypass is done using vasodilators such as nitroprusside, nitroglycerine and calcium antagonists such as nifedipine [15,16], In some cases catecholamines in combination with PDE inhibitors help patients with a low cardiac output state [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Postischemic Hemodynamic Changes after Piroximone Administration in Isolated Rabbit Heart

Zwölfer

Podesser²,

Wollenek³

et al. 1994

Eur Surg Res

View full text Add to dashboard Cite

In an experimental study on 22 adult Elco rabbits, hemodynamic parameters were investigated using a working heart model. The study group (10 rabbit hearts) received 1 mg/kg i.v. of the phosphodiesterase inhibitor piroximone 15 min before thoracotomy. 12 untreated rabbit hearts served as a control group. Hemodynamic parameters were measured before and after 60 min of hypothermic ischemia. The pre-ischemic period showed no significant differences between the two groups, except the higher levels of coronary flow in the piroximone group. The postischemic period showed significant increases in heart rate, coronary flow, aortic flow and cardiac output in the piroximone group in comparison to the control group. These results indicate as a main effect the positive influence of piroximone on coronary flow, given as a single shot 15 min preoperatively. This study provides evidence of the vasodilative properties on the coronary arteries beside the documented effects on the periphery. Therefore, piroximone represents an alternative tool in weaning from the cardiopulmonary bypass.

show abstract

“…However, there is evidence that these agents may, have a future major role in CHF treatment (e.g. Jafri et al, 1986;Arbogast et al, 1986).…”

Section: Introductionmentioning

confidence: 99%

In vivo pharmacological studies with SK&F 94836, a potent inotrope/vasodilator with a sustained duration of action

Gristwood¹,

Comer²,

Eden³

et al. 1988

British J Pharmacology

View full text Add to dashboard Cite

4 The inodilator activity of SK&F 94836 in conscious and anaesthetized animals occurred in association with minimal changes in either blood pressure or heart rate. 5 Detailed studies carried out on anaesthetized cats indicated that SK&F 94836 caused a balanced dilatation of both resistance and capacitance blood vessels. 6 Haemodynamic studies in anaesthetized cats indicated that as a consequence of the inotropic/ vasodilator actions, SK&F 94836 caused significant increases in cardiac output and stroke volume. 7 Detailed studies in anaesthetized dogs indicated that significant inodilator activity occurred in the absence of an increase in myocardial oxygen consumption. 8 The duration of action of SK&F 94836 was sustained following both i.v. and oral administration. 9 We conclude that SK&F 94836, as an orally active inotropic/vasodilator agent with a sustained duration in vivo, has potential utility in the treatment of congestive heart failure.

show abstract

Acute Hemodynamic Effects of Piroximone (MDL 19,205) in Patients with Moderate Congestive Heart Failure: Comparison with Sodium Nitroprusside

Cited by 21 publications

References 0 publications

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart – A Second Look Including Biochemical Data

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart – A Second Look Including Biochemical Data

Postischemic Hemodynamic Changes after Piroximone Administration in Isolated Rabbit Heart

In vivo pharmacological studies with SK&F 94836, a potent inotrope/vasodilator with a sustained duration of action

Contact Info

Product

Resources

About

Acute Hemodynamic Effects of Piroximone (MDL 19,205) in Patients with Moderate Congestive Heart Failure: Comparison with Sodium Nitroprusside

Cited by 21 publications

References 0 publications

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart &ndash; A Second Look Including Biochemical Data

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart &ndash; A Second Look Including Biochemical Data

Postischemic Hemodynamic Changes after Piroximone Administration in Isolated Rabbit Heart

In vivo pharmacological studies with SK&F 94836, a potent inotrope/vasodilator with a sustained duration of action

Contact Info

Product

Resources

About

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart – A Second Look Including Biochemical Data

Preischemic Bolus Application of Piroximone Studied on the Isolated Rabbit Heart – A Second Look Including Biochemical Data