Acute hemodynamic effects of the two dopaminergic agonists ibopamine and dihydroergotamine: A comparison with the parent compound

Ibopamine as a Valuable Adjunct and Substitute for Dopamine in Bridging Therapy before Heart Transplantation

“…Similar efficacy in substitution of intrave nous catecholamines and hemodynamic stabi lization of patients with severe heart failure by ibopamine has been presented by Dei Cas et al [6] and Mizutani [7], In a dose of 100 mg. ibo pamine has comparable effects on hemody namics and dirucsis as dopamine infusions of 2-4 (ig/kg/min [8], By activation of dopamin ergic receptors in renal vascular beds, ibopam ine can decrease diuretic demands without major changes of electrolyte balance [9. 10], Previous studies have not shown evidence of tolerance development during chronic therapy with this new drug [11,12], Thus, ibopamine can be a suitable adjunct for patients with end-stage heart failure await ing cardiac transplantation.…”