Acute Hepatitis Associated With Cetirizine Intake

Sánchez-Lombraña, J L; Álvarez, Ramón; Rodrigo, Luı́s; Oliva, Narcisco Pérez; Martínez, Rosa María Simó

doi:10.1097/00004836-200204000-00030

Cited by 16 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A 14-year-old girl developed acute hepatitis >2 months after the initiation of intermittent treatment with cetirizine. 5 The antihistamine had been prescribed to prevent a local cutaneous allergic reaction to the subcutaneous administration of a desensitizing vaccine toward house dust and mites. The vaccine was administered once a month, and the patient had been instructed to take cetirizine 10 mg the day before vaccination, the day of vaccination, and the day after vaccination.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Recurrent Acute Hepatitis Associated with Use of Cetirizine

Pompili

Basso²,

Grieco³

et al. 2004

Ann Pharmacother

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

“…These include one case of intrahepatic cholestasis 2 and 3 cases of acute hepatitis with probable toxic mechanisms. 3–5 We describe a case of recurrent acute hepatitis induced by repeated exposure to cetirizine and present evidence of the possible involvement of an autoimmune-mediated mechanism.…”

mentioning

confidence: 99%

Recurrent Acute Hepatitis Associated with Use of Cetirizine

Pompili

Basso²,

Grieco³

et al. 2004

Ann Pharmacother

View full text Add to dashboard Cite

show abstract

“…There are, however, side effects associated with use of both agents: Asthma patients treated with AZE over extended time periods report taste disorders, asthenia, and weight gain (19); with one report of the drug inducing a seizure in an epileptic patient being treated for asthma (20). CTZ is known to have hepatotoxic properties (21,22) and despite its classification as a non-sedating antihistamine, drowsiness and fatigue are also associated with its use in some patients (23); and it has additionally been reported to induce urticaria (24). Hence therapy based on naturally-occuring products with few side-effects is a desireable alternative to these and similar agents.…”

Section: Introductionmentioning

confidence: 99%

In Vitro Effects of Astaxanthin Combined With Ginkgolide B on T Lymphocyte Activation in Peripheral Blood Mononuclear Cells From Asthmatic Subjects

et al. 2004

View full text Add to dashboard Cite

Abstract. This study was undertaken to identify novel approaches to pharmacological treatment of asthma. Here we hypothesize that the platelet-activating factor receptor antagonist ginkgolide B (GB) in combination with the antioxidant carotenoid astaxanthin (ASX) suppresses T cell activation comparably to two commonly-used antihistamines: cetirizine dihydrochloride (CTZ) and azelastine (AZE). Peripheral blood mononuclear cells from asthmatics, cultured 24 h with either 50 mg / ml phytohemaglutinin (PHA) or PHA plus selected dosages of each drug are analyzed by flow cytometry for CD25+ or HLA-DR+ on CD3+ (T cells). Results are reported as stimulation indices (SI) of %CD3+CD25+ cells or %CD3+HLA-DR+ cells in cultures treated with PHA alone versus these subpopulations in cultures treated with both PHA and drugs. Combinations of ASX and GB exhibited optimal suppression at 10 -7 M GB + 10 -8 M ASX for CD3+CD25+ (SI = 0.79 ± 0.04, P = 0.001) and 10 -7 M GB + 10 -7 M ASX for CD3+HLA-DR+ (SI = 0.82 ± 0.05, P = 0.004). In conclusion, suppression of T cell activation below fully stimulated values by GB, ASX, and their combinations was comparable and for some combinations better than that mediated by CTZ and AZE. These results suggest that ASX and GB may have application as novel antiasthmatic formulations.

show abstract

Current Awareness: Pharmacoepidemiology and Drug Safety

2002

Pharmacoepidemiology and Drug

View full text Add to dashboard Cite

In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of pharmacoepidemiology and drug safety. Each bibliography is divided into 19 sections: 1 Books, Reviews & Symposia; 2 General; 3 Anti‐infective Agents; 4 Cardiovascular System Agents; 5 CNS Depressive Agents; 6 Non‐steroidal Anti‐inflammatory Agents; 7 CNS Agents; 8 Anti‐neoplastic Agents; 9 Haematological Agents; 10 Neuroregulator‐Blocking Agents; 11 Dermatological Agents; 12 Immunosuppressive Agents; 13 Autonomic Agents; 14 Respiratory System Agents; 15 Neuromuscular Agents; 16 Reproductive System Agents; 17 Gastrointestinal System Agents; 18 Anti‐inflammatory Agents ‐ Steroidal; 19 Others. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted.

show abstract

Acute Hepatitis Associated With Cetirizine Intake

Cited by 16 publications

References 7 publications

Recurrent Acute Hepatitis Associated with Use of Cetirizine

Recurrent Acute Hepatitis Associated with Use of Cetirizine

In Vitro Effects of Astaxanthin Combined With Ginkgolide B on T Lymphocyte Activation in Peripheral Blood Mononuclear Cells From Asthmatic Subjects

Current Awareness: Pharmacoepidemiology and Drug Safety

Contact Info

Product

Resources

About