Acute hepatitis C infection: an indication for alfa interferon therapy?

Vlies, C.H. van der; Tang, Thjon J.; Niesters, Hubert G. M.; Zondervan, Pieter E.; Janssen, Harry L.A.; Man, Robert A. de

doi:10.1016/s0300-2977(00)00027-9

Cited by 1 publication

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“…However the optimum therapeutic regimen and duration of therapy for acute HCV infection had not been defined. In most studies patients with acute HCV infection were treated with daily application of interferon-α [1,5,6]. There were only two case reports and a small trial (nine cases) regarding the safety and efficacy of using either interferon-α or pegylated interferon plus ribavirin in patients with acute HCV infection [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

“…Detection of HCV RNA should be done 12 weeks after the onset of jaundice, and treatment should be started if the result is positive [12]. In a state of marked endogenous immunological activation interferon-α might induce an uncontrolled immunological process, which could increase hepatic activity [6]. Therapy could be started more safely at the time when ALT activity decreasing, like in our case.…”

Section: Discussionmentioning

confidence: 99%

“…The histologic finding is necessary evaluated in continuity of clinical and serologic data. The important for treatment of acute HCV infection is fact that patients after passed viral hepatitis C (only anti-HCV positive) had proved chronic hepatitis by histologic examination of liver in future [1,2,6]. …”

Section: Discussionmentioning

confidence: 99%

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Treatment of acute hepatitis C virus infection with interferon-α 2b and ribavirin: Case report and review of the literature

Leblebicioğlu

Bayirli

Esen

et al. 2002

Ann Clin Microbiol Antimicrob

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Hepatitis C virus (HCV) infection becomes chronic in about 85 % of individuals as demonstrated by the persistence of HCV. It is necesseray to treat acute hepatitis C infection. Interferon-a is generally used for the treatment of acute HCV infection. Case presentation:A 55-year-old woman with a history of fatique and icter was diagnosed as acute hepatitis C virus infection. She was treated with interferon-a 2b 3 million unite sc three times in a week and ribavirin 1000 mg daily for 6 months. Within 2 weeks of therapy, the alanine aminotransferase (ALT) had became normal. At the end of the 3 months of therapy, HCV RNA was negative and remained negative 6 months after the end of interferon treatment (sustained response). Conclusion:This report suggests that interferon-a 2b and ribavirin may have a role in treatment of acute hepatitis C virus infection.

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