Acute Hepatitis Induced by a Unique Combination of Herbal Supplements

Alali, Fadi; Hermez, Klodia; Ullah, Nadeem

doi:10.14309/00000434-201810001-03025

Cited by 2 publications

(2 citation statements)

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“…Aloe vera-induced hepatotoxicity has been reported widely in countries such as Korea, Germany, and the United States, among many others [6][7][8]. Other supplements, such as ashwagandha, have also been shown to cause hepatitis, particularly when taken in conjunction with additional supplements or drugs [9][10][11]. While it is difficult to discern whether ashwagandha alone is sufficient to cause hepatitis, more cases are emerging in patients who are consuming more than one type of supplement or taking supplements with concomitant use of alcohol or other prescribed or non-prescribed medications.…”

Section: Discussionmentioning

confidence: 99%

A Case of Supplement-Induced Hepatitis

Pusec¹,

Wolsky²,

Llerena³

et al. 2022

Cureus

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Acute hepatitis is an uncommon sequela of herbal supplement use. Regardless, considering the hepatotoxic effects of natural supplements is important, especially in patients taking other medications or substances. We herein describe a case of acute steatohepatitis in a patient who chronically consumed high doses of ashwagandha and other herbal supplements in the context of alcohol use and a multi-medication regimen.

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Section: Discussionmentioning

confidence: 99%

A Case of Supplement-Induced Hepatitis

Pusec¹,

Wolsky²,

Llerena³

et al. 2022

Cureus

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“…[7][8][9][10] However, recent studies suggest potential for hepatotoxicity, though without clear guidance about which patients are most at risk. 5,11,12 A study by Inagaki and colleagues suggests the potential for dose-dependent mechanism of liver injury, and this is supported by in vitro CYP450 inhibition with high doses of W Somnifera extract. 11,13 We hypothesize that there may be a multihit process that makes some patients more susceptible to supplement harm, particularly those with repeated exposures and with ongoing exposure to hepatic toxins, such as AUD.…”

Section: Discussionmentioning

confidence: 98%

Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha

Vazirani

2023

Federal Practitioner

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FEDERAL PRACTITIONER • 315 mdedge.com/fedprac Background: As patients look more to alternative herbal and dietary supplements to boost energy and mood, reports are increasing of unintended adverse effects, particularly to the liver. Case Presentation: We report a case of a 48-year-old man with a history of severe alcohol use disorder who presented to the emergency department with a cholestatic pattern of liver injury in the setting of alcohol and use of a testosteroneboosting supplement containing ashwagandha.Conclusions: Drug-induced liver damage should be considered in patients with alcohol use disorder who present with a cholestatic pattern of liver injury. Although many natural substances are well tolerated, others can have unanticipated and harmful adverse effects and drug interactions. Future research should identify not only potentially harmful substances, but also which patients may be at greatest risk.

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Acute Hepatitis Induced by a Unique Combination of Herbal Supplements

Cited by 2 publications

References 0 publications

A Case of Supplement-Induced Hepatitis

A Case of Supplement-Induced Hepatitis

Supplements Are Not a Synonym for Safe: Suspected Liver Injury From Ashwagandha

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