Acute hepatitis m childhood: virological, immunological and clinical aspects

Nigro, Giovanni; Bartmann, U.; Mattia, S.; Nastasi, Valentina; Torre, Andrea; Manganaro, M; Perrone, Tommasina; Tucciarone, L

doi:10.1016/0753-3322(92)90023-z

Cited by 5 publications

(1 citation statement)

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“…Long-term sequelae of liver infection, including biliary disease and fibrosis, have been reported in congenitally or perinatally infected infants [5,6]. CMV hepatitis is now recognized as being more frequent and severe in previously healthy children than earlier studies suggested, with persistent inflammation, hepatomegaly and clinical disease described [7,8]. Furthermore, hepatic dysfunction is common in previously healthy adults who develop CMV mononucleosis, and may be fatal [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Cytomegalovirus hepatitis: characterization of the inflammatory infiltrate in resistant and susceptible mice

Olver

Price

Shellam

1994

Clinical and Experimental Immunology

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SUMMARYMice susceptible and resistant to murine cytomegalovirus (MCMV) were infeeted with this virus and livers were harvested after 2-231 days. Cryostat sections were stained to visualize cells bearing CD4, CDS or Mac-1 antigens. Mac-1 ^ cells were prevalent in inflammatory foci after 2 days. These cells persisted in susceptible BALB/c and A/J mice, but disappeared from livers of resistant C57BI/ 6 and CBA/CaH mice by day 28. T cell inflammation peaked on days 7-11. This declined by day 56 in C57BI/6 and CBA/CaH mice, but persisted in BALB/c and A/J mice for at least 231 days. Persistent CD8* cells were dispersed throughout the parenchyma. More CD8"^ cells were observed 7-14 days after infection in the livers of bg/bg (natural killer (NK) cell-deficient) C57B1/6 and CBA mice, and in C57BI/6 mice depleted of NKl.l cells by MoAb. Thus, miee of strains susceptible to MCMV exhibit hepatitis characterized by persistence of dispersed CD8^ cells. This phenomenon may be limited by NK ceils in resistant strains.

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