Acute high-intensity interval rowing increases thrombin generation in healthy men

Abstract

PurposeHigh-intensity exercise induces several health benefits, but may acutely and transiently increase the risk of cardiovascular events due to thrombotic changes promoting blood coagulation and thrombin formation. This study examined the effects of high-intensity exercise on plasma thrombin generation and triacylglycerol concentrations.MethodsSixteen healthy men completed two, 2-day conditions separated by 1 week. On day 1, participants rested (control) or completed four, 3-min high-intensity rowing intervals at an average rating of perceived exertion of 17 (exercise). Venous blood samples were collected pre- and post-intervention to determine plasma thrombin generation. On day 2, participants rested and consumed a glucose load (0 h) and high-fat meal (2 h). Fifteen venous blood samples were collected between 0 and 8 h to measure plasma thrombin generation and triacylglycerol concentrations.ResultsOn day 1, lag time was shorter and peak thrombin and endogenous thrombin potential were greater in the exercise than control condition (ES ≥ 0.37, main effect condition P ≤ 0.03), and post-intervention compared with pre-intervention (ES ≥ 0.49, main effect time P ≤ 0.003). The magnitude of the post-intervention change was greater in the exercise than control condition for all thrombin generation parameters (condition by time interaction P ≤ 0.05). On day 2, no differences in postprandial thrombin generation parameters were seen between conditions (P ≥ 0.21). The total area under the curve for triacylglycerol was lower in the exercise than control condition (ES = 0.34, P = 0.02).ConclusionAn acute bout of high-intensity interval rowing increased plasma thrombin generation immediately after exercise, but these differences were eliminated 16–24 h after exercise.

Effects of Repeated Bouts of Exercise on the Hemostatic System

“…This is in accordance with findings from a recent study in which an acute bout of high-intensity exercise increased TG immediately after exercise, but returned to baseline the following day. 20 Remarkably, almost no increase in ETP was observed after cycling on the second and third day. The ETP before exercise actually decreased over the 3 days of cycling (►Fig.…”

“…17 Exercise is known to exert a plethora of effects on hemostasis. These include increased levels of clotting factors (factor VIII [FVIII] and von Willebrand factor [VWF]), platelet count and reactivity, a shortening of the activated partial thromboplastin time (aPTT) 18,19 and increased thrombin generation (TG), 20 as well as increases in fibrinolytic markers (prothrombin fragments 1 þ 2 and thrombin-antithrombin complexes). 21,22 Altogether, these changes result in a shift toward a transient hypercoagulable state, 23 that depends at least partly on exercise intensity.…”

Dietary Antiplatelets: A New Perspective on the Health Benefits of the Water-Soluble Tomato Concentrate Fruitflow®

“…On a molecular level, during exercise, we are inducing an inflammatory burst, which is mediated by platelets. Strenuous exercise releases adrenalin and serotonin and generates thrombin [ 40 ], resulting in platelet activation [ 33 ]. In addition, intense aerobic exercise can reduce the amount of anti-aggregatory nitric oxide (NO) produced by the vascular endothelium, especially in untrained subjects, as the amount of oxygen reaching the NO-producing cells is reduced [ 41 ].…”

Study of Effect of Various Grades of Exercise on Serum Proteins in Healthy Young Indian Adults

“…In vigorously exercising subjects compared with the controlsincreased levels of aspartate transaminase (AST), total protein (TP), albumin, urea and high density lipoprotein-cholesterol (HDL-C) were observed while the levels of Na+, K+, cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C) and glucose were significantly reduced as found byJohnson JL et al (2007) [8] . The level of proteins that differ between groups indicate a long-term exercise effect on plasma protein concentrations was a important finding of Schild M et al (2016) [9] .Sedgwick MJet al (2016) [10] observed that acute bout of high-intensity interval rowing increased plasma thrombin generation immediately after exercise, but these differences were eliminated 16-24 h after exercise.…”