Acute HIV Infection Presenting With Diffuse Plaque Psoriasis Treated With Highly Active Antiretroviral Therapy

Bressler, Moshe Y.; Pathak, Naeha; Rotblat, David; Tamez, Rebecca

doi:10.7759/cureus.19680

Cited by 1 publication

(2 citation statements)

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“…Improvement of psoriasis in PLHIV receiving ARV was reported in several case reports/series 34–36 . The National Psoriasis Foundation Medical Board recommended ARV and phototherapy as a first‐line treatment for moderate‐to‐severe psoriasis 16 .…”

Section: Discussionmentioning

confidence: 98%

“…Improvement of psoriasis in PLHIV receiving ARV was reported in several case reports/series. [34][35][36] The National Psoriasis Foundation Medical Board recommended ARV and phototherapy as a first-line treatment for moderate-to-severe psoriasis. 16 The antipsoriatic efficacy of ARV may relate to tumor necrosis factorα (TNFα), which is a pivotal cytokine in the pathogenesis of both psoriasis and HIV.…”

Section: Ta B L E 3 (Continued)mentioning

confidence: 99%

See 1 more Smart Citation

Retrospective study of psoriasis in people living with HIV: Thailand’s experience

Chaiyabutr

Jiamton

Silpa‐archa

et al. 2022

The Journal of Dermatology

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Psoriasis is a common and chronic acquired skin inflammatory disorder. Its estimated prevalence in adult populations ranges from 0.14% in East Asia to 1.99% in Australasia. 1 The majority of countries with a high psoriasis prevalence are among the high-income countries with older populations, which include Europe (1.83%-1.92%) and North America (1.50%). 1 HIV, which causes AIDS, is a serious global epidemic infection.With the advent of superb antiretroviral drugs (ARV), people living with HIV (PLHIV) now enjoy longer life expectancies, and as a result, the number of PLHIV has greatly increased. In 2019, there were approximately 38 million PLHIV globally. The prevalence of PLHIV varies from country to country, and it is higher in low-income countries, especially Africa. 2 In 2021, Thailand, an upper-middle-income country, was estimated to have 470 000 PLHIV out of a population of nearly 70 million. 3,4 Many previous reports have reported an association between psoriasis and HIV. In terms of its epidemiology, psoriasis is the most common skin autoimmune disease in PLHIV. 5 Moreover, HIV was recently found to be an independent factor for incident psoriasis. 6 PLHIV with positive HLA-B*5701 have around a threefold increased risk of psoriasis, compared with PLHIV with negative HLA-B*5701. 7 Psoriasis can be found in every stage of HIV infection. Psoriasis in PLHIV has been reported to be more severe, have more atypical presentations, and be more refractory to treatment than in general psoriasis patients. 8,9 The severity of psoriasis has also been associated with a low CD4 count. 10 Plaque psoriasis appears to be the most common clinical type in PLHIV, with the predilection sites being the scalp and the palmoplantar and flexural areas. 11 A recent case series

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Section: Discussionmentioning

confidence: 98%