Acute hydrated non‐compressive nucleus pulposus extrusion: what do we know so far?

Beltrán, Elsa

doi:10.1136/vr.j5494

Cited by 2 publications

(1 citation statement)

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“…ANNPE is characterized by NP extrusion through a tear in the annulus fibrosus of a nondegenerate IVD, usually whose age of onset is comparatively old with a narrowed affected IVD. [9] Normally, a healthy IVD maintains a hyperosmolar environment, which is produced by vast amounts of extracellular matrix (ECM) that contains high concentrations of proteoglycans whose hydrophilic GAG side chains promote water and cation retention; the negatively charged proteoglycans of the IVD can attract water molecules into the disc and contribute to tissue swelling. [10] In contrast, NP cells may function as an important element for controlling water transport and responding to osmotic changes.…”

Section: Discussionmentioning

confidence: 99%

Probable lumbar acute noncompressive nucleus pulposus extrusion: a case report of acute pain caused by a hydrated nucleus pulposus and review of the literature

Chen

Gao

et al. 2021

Emergency and Critical Care Medicine

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Acute noncompressive nucleus pulposus (NP) extrusion has been widely described in veterinary medicine, especially in dogs and cats; however, cases have rarely been reported in humans. We report a rare case of acute pain caused by a hydrated NP. Magnetic resonance imaging revealed an obvious hyperintense signal on T2-weighted images at the L5/S1 segments, while computed tomography imaging and radiography revealed a mildly herniated disc at the L4/5 level and slight lumbar spondylolisthesis at the L5/ S1 segments. The operation was performed to confirm the presence of a red and swollen nerve root on the right side of the hydrated L5/S1 segment. The patient's severe pain disappeared, and full recovery was achieved months after surgery. Thus, our case demonstrated a probable lumbar acute noncompressive NP extrusion in humans and reported associated symptoms and imaging characteristics. In such circumstances, surgical management is indicated and may be associated with a good outcome.

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Section: Discussionmentioning

confidence: 99%