Acute hypotension attenuates brachial flow-mediated dilation in young healthy men

Iwamoto, Erika; Yamada, Yutaka; Katayose, Masaki; Sakamoto, Rintaro; Neki, Toru; Sugawara, Jun; Ogoh, Shigehiko

doi:10.1007/s00421-019-04260-0

Cited by 6 publications

(7 citation statements)

References 52 publications

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“…The decrease in MAP was caused by rapid blood redistribution to the lower extremities, secondary to cuff deflation. A previous study using the same maneuver showed a MAP drop of 23 ± 7 mmHg 9 or 23.7 ± 6.0 mmHg 10 . Cuff inflation and sudden deflation can induce an acute blood pressure drop of 20-30 mm Hg in healthy young males.…”

Section: Map Changesmentioning

confidence: 57%

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Repeated acute hypotension induced by thigh cuff release and cerebral oxygenation changes

Tsubaki,

Tamiya,

Baba

et al. 2024

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables V

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Normal brain function depends on stable cerebral blood flow and autoregulation. Cerebral blood flow is maintained even when blood pressure fluctuates in daily life. However, microcirculation in the cortex, when blood pressure drops rapidly and repeatedly, is poorly understood. This study aimed to determine oxyhemoglobin (O2Hb) levels, which may reflect cortical blood flow changes, during repeated hypotension cycles induced by thigh cuff release. Twelve healthy students participated in this study. Each participant was seated in the recumbent position in a quiet room. Cuffs of digital tourniquets were placed on both thighs and inflated to 250 mmHg for 5 min after 5 min of rest, followed by deflation for 5 min, which was repeated four times. Right (R) and left (L) prefrontal cortex (PFC) O2Hb levels were measured using a multichannel near-infrared spectroscopy system (LABNIRS; Shimadzu Co., Tokyo, Japan). Beat-to-beat mean arterial pressure (MAP) was recorded by finger pulse volume using photoplethysmography (Finometer; Finapres Medical Systems, Amsterdam, the Netherlands), and O2Hb and MAP were averaged over 1-s epochs throughout the study. Ultimately, there were no significant changes in MAP or O2Hb levels among the four measurements. This study demonstrates that repeated hypotension induced by thigh cuff release does not lead to any lowering effects on MAP or O2Hb.

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Section: Map Changesmentioning

confidence: 57%

“…This occlusion-deflation cycle was repeated four times. Sudden deflation of the thigh cuff can induce acute hypotension noninvasively and nonpharmaceutically [8][9][10] . O2Hb levels, which are indicative of cortical microcirculation changes, and mean arterial pressure (MAP) were continuously measured throughout the experiment.…”

Section: Methodsmentioning

confidence: 99%

Repeated acute hypotension induced by thigh cuff release and cerebral oxygenation changes

Tsubaki,

Tamiya,

Baba

et al. 2024

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables V

View full text Add to dashboard Cite

show abstract

“…This decrease was caused by the rapid blood redistribution to the lower extremities resulting from the cuff deflation. A previous study using the same thigh cuff maneuver demonstrated a MAP drop of 23 ± 7 mmHg 12 or 23.7 ± 6.0 mmHg 13 . Cuff inflation and sudden deflation can induce a 20 to 30 mmHg acute drop in blood pressure.…”

Section: Map Changesmentioning

confidence: 69%

“…Following sudden deflation, the participants were observed for 5 minutes. The sudden deflation of the thigh cuff can induce acute hypotension non-invasively and non-pharmaceutically [11][12][13] . O2Hb levels indicative of cortical microcirculation change and mean arterial pressure (MAP) were continuously measured throughout the experiment.…”

Section: Methodsmentioning

confidence: 99%

Acute hypotension induced by thigh cuff release and cerebral oxygenation alternations

Tsubaki

Qu²,

Qin³

et al. 2023

Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV

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Normal brain function is dependent on stable cerebral blood flow and autoregulation. Even when blood pressure fluctuates, cerebral blood flow is maintained. However, the microcirculation of the cortex has not been thoroughly investigated during rapidly induced hypotension. This study aimed to determine oxyhemoglobin (O2Hb) levels, indicative of cortical blood flow changes, during hypotension induced by thigh cuff release. Twenty-one healthy students participated in this study. Each participant was seated in a recumbent position in a quiet room for 5 minutes. Cuffs of digital tourniquets were placed on both thighs and inflated to 250 mmHg for 5 minutes. Following sudden deflation, the participants were observed for 5 minutes. Right (R) and left (L) prefrontal cortex (PFC) O2Hb levels were measured using a multichannel near-infrared spectroscopy system. Using photoplethysmography, the beat-to-beat mean arterial pressure (MAP) was recorded by finger pulse volume. O2Hb and MAP were averaged 1-second epoch throughout the study. MAP decreased from 95.2 ± 9.9 mmHg to 63.5±9.0 mmHg after cuff release. The time from release to the lowest O2Hb was significantly slower than the time from release to the lowest MAP (p < 0.01); time difference, 3.6 ± 2.2 s in the L-PFC and 3.5 ± 1.8 s in the R-PFC. These results suggest that hypotension induced by thigh cuff release decreases the O2Hb levels in both L and R-PFC with a 3.5–3.6 s delay.

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“…We interpolated ICA parameters to 1 Hz prior to subjecting data to a two-stage filtering process (median filter and Savitzky-Golay finite impulse response smoothing filter). In brief, (D base ) and SR were analysed during the last minute and peak diameter (D peak ) were then assessed visually to ensure that: the detected peak SR preceded the detected D peak [7,[31][32][33][34]. BA and ICA SR were calculated using the equation; 4 × mean velocity/arterial diameter.…”

Section: Discussionmentioning

confidence: 99%

Effects of continuous hypoxia on flow-mediated dilation in the cerebral and systemic circulation: on the regulatory significance of shear rate phenotype

et al. 2022

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Emergent evidence suggests that cyclic intermittent hypoxia increases cerebral arterial shear rate and endothelial function, whereas continuous exposure decreases anterior cerebral oxygen (O2) delivery. To examine to what extent continuous hypoxia impacts cerebral shear rate, cerebral endothelial function, and consequent cerebral O2 delivery (CDO2), eight healthy males were randomly assigned single-blind to 7 h passive exposure to both normoxia (21% O2) and hypoxia (12% O2). Blood flow in the brachial and internal carotid arteries were determined using Duplex ultrasound and included the combined assessment of systemic and cerebral endothelium-dependent flow-mediated dilatation. Systemic (brachial artery) flow-mediated dilatation was consistently lower during hypoxia (P = 0.013 vs. normoxia), whereas cerebral flow-mediated dilation remained preserved (P = 0.927 vs. normoxia) despite a reduction in internal carotid artery antegrade shear rate (P = 0.002 vs. normoxia) and CDO2 (P < 0.001 vs. normoxia). Collectively, these findings indicate that the reduction in CDO2 appears to be independent of cerebral endothelial function and contrasts with that observed during cyclic intermittent hypoxia, highlighting the regulatory importance of (hypoxia) dose duration and flow/shear rate phenotype.

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Acute hypotension attenuates brachial flow-mediated dilation in young healthy men

Cited by 6 publications

References 52 publications

Repeated acute hypotension induced by thigh cuff release and cerebral oxygenation changes

Repeated acute hypotension induced by thigh cuff release and cerebral oxygenation changes

Acute hypotension induced by thigh cuff release and cerebral oxygenation alternations

Effects of continuous hypoxia on flow-mediated dilation in the cerebral and systemic circulation: on the regulatory significance of shear rate phenotype

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