Acute Hypotonia in an Infant

Acute Flaccid Myelitis: Review of Clinical Features, Diagnosis, and Management with Nerve Transfers

“…After removal of duplicates and initial screening, 500 were reviewed and assessed for eligibility. After application of inclusion and exclusion criteria, 99 articles were included in this study (55 case reports/series, 1,4–7,9–57 33 retrospective cohort studies, 2,3,58–88 seven cross-sectional studies, 89–95 and four case-control studies 96–99 ) (Fig. 1).…”

“…Inflammatory markers were occasionally elevated in AFM, 33,49,57 but were often normal. 1,7,11,13,25,53 Cytokine markers for AFM are currently being investigated, 31,99 although none has been definitively established.…”

Unmet Needs in the Evaluation, Treatment, and Recovery for 167 Children Affected by Acute Flaccid Myelitis Reported by Parents Through Social Media

“…4 However, larger biennial AFM clusters reported in 2014 and 2016 (326 cases were confirmed between August 2014 and June 2018), as well as in 2018 (additional 158 cases confirmed for 2018 of 311 reports under investigation), highlighted the fact that AFM rates were indeed rising. 5 A number of case reports and series have been published describing mainly the 2014 and 2016 experiences with non-polioerelated AFM regionally (among others, in Arizona, 6 Colorado, 7e9 Florida, 10 Missouri, 11 Utah, 12 Washington, 13 nationally 14,15 and internationally including Argentina, 16 Spain, 17 Germany, 18 Japan, 19 China, 20 and Australia/New Zealand 21 ). These clusters of AFM coincided temporally with the first documented national outbreak of Enterovirus D68 (EV-D68), 22 a respiratory virus first identified in California in 1962 but which until 2014 had remained rare.…”