Acute Hypoxemic Respiratory Failure in Sarcoidosis: A Case Report and Literature Review

Gupta, Dheeraj; Agarwal, Ritesh; Paul, Abinash S; Joshi, Kusum

doi:10.4187/respcare.01174

Cited by 5 publications

(2 citation statements)

References 13 publications

(7 reference statements)

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“…4 Our patient presented with cough, shortness of breath, and diffuse pulmonary infiltrates, which then progressed to acute respiratory failure. Although there are reports of sarcoidosis presenting with acute respiratory failure in adults, [5][6][7][8] this is the first pediatric case where acute respiratory failure developed during the initial presentation of sarcoidosis. Our patient was initially treated with antibiotics and antifungal therapy, but there was no response and BAL cultures remained negative.…”

Section: Discussionmentioning

confidence: 88%

An 11-Year-Old Boy with Diffuse Pulmonary Infiltrates and Respiratory Failure

Sandhu¹,

Sklar²,

Kumar³

et al. 2014

Pediatr Ann

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Healio.com/Pediatrics | 181Editor's note: Each month, this department features a discussion of an unusual diagnosis. A description and images are presented, followed by the diagnosis and an explanation of how the diagnosis was determined. As always, your comments are welcome via email at pedann@Healio.com.A n 11-year-old African-American boy with no significant medical history presented to the emergency department (ED) with a 1-week history of dry, non-productive cough associated with shortness of breath and headaches. No history of fevers, vomiting, diarrhea, throat or ear pain, or recent travel was noted. The

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Section: Discussionmentioning

confidence: 88%

An 11-Year-Old Boy with Diffuse Pulmonary Infiltrates and Respiratory Failure

Sandhu¹,

Sklar²,

Kumar³

et al. 2014

Pediatr Ann

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“…In this case report, an extremely rare presentation of a very common disease has been reported. Indeed, in English language medical literature only 7 previous cases of sarcoidosis causing respiratory failure can be found[ 3 4 5 6 7 8 9 ] and this is the first one in Europe. In our experience patient's conditions progressively worsened, developing respiratory failure with ARDS and requiring intensive treatment with CPAP.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary sarcoidosis presenting with acute respiratory distress syndrome

Arondi¹,

Valsecchi²,

Borghesi³

et al. 2016

Ann Thorac Med

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Sarcoidosis is a common disease that involve almost constantly the lung. Usually the onset is insidious, and symptoms are slowly ingravescent. Very rarely, as in the case here reported, sarcoidosis can cause an acute respiratory failure with acute respiratory distress syndrome (ARDS). A 20-year-old girl from Pakistan presented for acute fatigue, fever, and cough with a chest X-ray displayed the micronodular interstitial disease. Despite of anti-tuberculosis therapy, ARDS developed in a few days requiring continuous positive airway pressure treatment. Examinations on transbronchial specimens obtained by bronchoscopy permitted to reach the diagnosis of sarcoidosis and steroid therapy improved rapidly clinical conditions. This is the first case report reported in Europe that confirms the rare onset of sarcoidosis as ARDS. Steroid therapy allows to cure rapidly this severe complication.

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Acute alveolar sarcoidosis presenting with hypoxaemic respiratory failure

Gera

Gupta²,

Ahuja³

et al. 2014

BMJ Case Reports

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Alveolar sarcoidosis is a less commonly seen pulmonary manifestation of the disease. An acute presentation of this radiological pattern with hypoxaemic respiratory failure has been documented only once, four decades ago. A 30-year-old man presented with acute onset of progressive and persistent dyspnoea over 20 days ago with hypoxaemic respiratory failure. Imaging demonstrated mediastinal lymphadenopathy and coalescent parenchymal alveolar opacities having ill-defined margins along with air bronchograms in the mid and lower zones bilaterally, suggestive of alveolar sarcoidosis. A restrictive pattern with a diffusion defect was seen on pulmonary function testing. Bronchoscopic evaluation revealed non-caseating granulomas on histopathology confirming pulmonary sarcoidosis. This was further supported by an elevated serum ACE level and negative Mantoux test. Oral prednisolone elicited a rapid clinical and radiological response. Alveolar sarcoidosis can rarely present acutely with hypoxaemic respiratory failure, which can respond remarkably and expeditiously to appropriate therapy.

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Acute Hypoxemic Respiratory Failure in Sarcoidosis: A Case Report and Literature Review

Cited by 5 publications

References 13 publications

An 11-Year-Old Boy with Diffuse Pulmonary Infiltrates and Respiratory Failure

An 11-Year-Old Boy with Diffuse Pulmonary Infiltrates and Respiratory Failure

Pulmonary sarcoidosis presenting with acute respiratory distress syndrome

Acute alveolar sarcoidosis presenting with hypoxaemic respiratory failure

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