Acute Garcinia mangostana (mangosteen) supplementation does not alleviate physical fatigue during exercise: a randomized, double-blind, placebo-controlled, crossover trial

Abstract

BackgroundThe purple mangosteen (Garcinia mangostana), known as the "queen of fruit," is widely consumed and unique not only because of its outstanding appearance and flavor but also its remarkable and diverse pharmacological effects. The aim of the present study is to evaluate the effect of acute mangosteen supplementation on physical fatigue during exercise.MethodsA randomized, double-blind, placebo-controlled, crossover study was carried out by 12 healthy adults. The participants were randomly assigned to receive acute oral administration of either 250 mL of the mangosteen-based juice (supplementation treatment; 305 mg of α-mangostin and 278 mg of hydroxycitric acid) or a placebo (control treatment) 1 h before cycle ergometer exercise. Time to exhaustion, heart rate, Borg Rating of Perceived Exertion score, blood biochemical markers (namely ammonia, cortisol, creatine kinase, aspartate aminotransferase, alanine aminotransferase, glucose, and lactate), muscle dynamic stiffness, and Profile of Mood States (POMS) were evaluated and recorded.ResultsThe results showed all parameters we examined were significantly altered by the exercise challenge, which demonstrated they directly reflected the condition of fatigue. However, there were no differences between the two treatments besides a positive impact on the POMS examination.ConclusionsThe occurrence of physical fatigue depends on multiple underlying mechanisms. We concluded that acute mangosteen supplementation had no impact on alleviating physical fatigue during exercise.

Mangosteen Pericarp and Its Bioactive Xanthones: Potential Therapeutic Value in Alzheimer’s Disease, Parkinson’s Disease, and Depression with Pharmacokinetic and Safety Profiles

“…Although there are no clinical data directly focusing on the effects of MP agents in the depressive patients, several studies have evaluated their impacts on mental health outcomes in humans. In a small randomized controlled trial (RCT), mangosteen-based supplementation containing 305 mg of α-MG and 278 mg of hydroxycitric acid was orally administered to healthy adults prior to cycle ergometer exercise and the parameters directly reflecting the condition of physical fatigue were measured [ 99 ]. All parameters measured showed no differences between the supplementation group and placebo group, except the Profile of Mood States (POMS) scores.…”

“…All parameters measured showed no differences between the supplementation group and placebo group, except the Profile of Mood States (POMS) scores. The single dose of mangosteen supplementation showed a positive impact on the scores of POMS, a psychological rating scale used to assess transient, distinct mood states [ 99 ].…”

The Therapeutic Potential of Mangosteen Pericarp as an Adjunctive Therapy for Bipolar Disorder and Schizophrenia

“…Due to the association between ROS and fatigue during exercise, Chang et al (109) trialed mangosteen in 12 healthy adults. Participants were randomized to receive an acute dose of either a mangosteen juice blend or a diluted drink that replaced 50% mangosteen juice with water.…”

Repressed Exercise-Induced Hepcidin Levels after Danggui Buxue Tang Supplementation in Male Recreational Runners

“…Serum levels of AST, ALT, and plasma ammonia are sensitive biomarkers that reflect the occurrence of physical fatigue. The concentrations of these biomarkers would increase during or after an exercise challenge [ 66 ]. However, although previous studies have shown that treatment with both AM and AS reduced ammonia production in mice in a dose-dependent manner [ 25 , 26 ], such findings were not in accordance with this study.…”