Acute ibuprofen ingestion does not attenuate fatigue during maximal intermittent knee extensor or all-out cycling exercise

Morgan, Paul T.; Vanhatalo, Anni; Bowtell, Joanna L.; Jones, Andrew M.; Bailey, Stephen J.

doi:10.1139/apnm-2018-0432

Cited by 6 publications

(4 citation statements)

References 54 publications

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“…Fortynine articles were fully reviewed; from the bibliography of these six, additional articles were selected and reviewed. Twenty articles were excluded because they did not assess the outcomes of interest, and data could not be extracted from the reported graphs, inadequate intervention; a total of 23 studies were included [17,18,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42] (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

Effect of Non-Steroidal Anti-Inflammatory Drugs on Sport Performance Indices in Healthy People: a Meta-Analysis of Randomized Controlled Trials

et al. 2020

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Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are medications that are frequently used by athletes. There may also be some abuse of these substances, although it is unclear whether NSAIDs in fact enhance performance. We performed a systematic review and meta-analysis to evaluate the effect of NSAIDs on sport performance indices. Methods: We selected randomized trials from the PubMed and Cochrane Library databases investigating the effects of NSAIDs on sport performance. Volunteers could be healthy adult men and women. Any NSAID, administered by any route, taken prior to any type of exercise, and for any duration could be used. The control intervention could be a placebo, an active substance, or no intervention. We included doubleblind, single-blind, and open-label studies. The primary outcome was the maximum performance in exercises as defined in each study. The secondary outcomes were the time until self-reported exhaustion and the self-reported pain. Results: Among 1631 records, we retained thirteen parallel-group and ten crossover studies, totaling 366 and 148 subjects, respectively. They were disparate regarding treatments, dose and duration, and the type of exercise. There was neither significant difference in the maximum performance between NSAIDs and control groups nor in the time until exhaustion nor in self-perceived pain. Conclusions: The existence of an ergogenic effect of NSAIDs on sport performance indices was unable to be concluded, since the level of evidence of the studies is low, the doses tested, and the exercises performed are very heterogeneous and far from those observed in real-life practices. More studies are required.

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Section: Resultsmentioning

confidence: 99%

Effect of Non-Steroidal Anti-Inflammatory Drugs on Sport Performance Indices in Healthy People: a Meta-Analysis of Randomized Controlled Trials

et al. 2020

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“…Immediately following transverse plane imaging of the thigh, while lying in the same position, sagittal plane sections of the right knee were collected (slice thickness: 3.00 mm, TR: 500 ms, TE: 10 ms, flip angle: 124°) to measure patella tendon moment arm length for the assessment of in-situ muscle-specific force. Finally, participants returned to the laboratory for an assessment of isometric leg strength and voluntary activation (VA) of the right quadriceps, determined via isokinetic dynamometry (Biodex System 3, Shirley, NY, USA), as previously described [ 49 ]. Briefly, participants completed 3 × 3 s MVC of the knee extensors with each contraction separated by a 60 s passive recovery period.…”

Section: Methodsmentioning

confidence: 99%

Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals

et al. 2023

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The mechanisms through which obesity impacts age-related muscle mass regulation are unclear. In the present study, rates of integrated myofibrillar protein synthesis (iMyoPS) were measured over 48-h prior-to and following a 45-min treadmill walk in 10 older-obese (O-OB, body fat[%]: 33 ± 3%), 10 older-non-obese (O-NO, 20 ± 3%), and 15 younger-non-obese (Y-NO, 13 ± 5%) individuals. Surface electromyography was used to determine thigh muscle “activation”. Quadriceps cross-sectional area (CSA), volume, and intramuscular thigh fat fraction (ITFF) were measured by magnetic resonance imaging. Quadriceps maximal voluntary contraction (MVC) was measured by dynamometry. Quadriceps CSA and volume were greater (muscle volume, Y-NO: 1182 ± 232 cm3; O-NO: 869 ± 155 cm3; O-OB: 881 ± 212 cm3, P < 0.01) and ITFF significantly lower (m. vastus lateralis, Y-NO: 3.0 ± 1.0%; O-NO: 4.0 ± 0.9%; O-OB: 9.1 ± 2.6%, P ≤ 0.03) in Y-NO compared with O-NO and O-OB, with no difference between O-NO and O-OB in quadriceps CSA and volume. ITFF was significantly higher in O-OB compared with O-NO. Relative MVC was lower in O-OB compared with Y-NO and O-NO (Y-NO: 5.5 ± 1.6 n·m/kg−1; O-NO: 3.9 ± 1.0 n·m/kg−1; O-OB: 2.9 ± 1.1 n·m/kg−1, P < 0.0001). Thigh muscle “activation” during the treadmill walk was greater in O-OB compared with Y-NO and O-NO (Y-NO: 30.5 ± 13.5%; O-NO: 35.8 ± 19.7%; O-OB: 68.3 ± 32.3%, P < 0.01). Habitual iMyoPS did not differ between groups, whereas iMyoPS was significantly elevated over 48-h post-walk in O-OB (+ 38.6 ± 1.2%·day−1, P < 0.01) but not Y-NO or O-NO (+ 11.4 ± 1.1%·day−1 and + 17.1 ± 1.1%·day−1, respectively, both P > 0.271). Equivalent muscle mass in O-OB may be explained by the muscle anabolic response to weight-bearing activity, whereas the age-related decline in indices of muscle quality appears to be exacerbated in O-OB and warrants further exploration.

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“…In a study from 2019, Morgan and collegues tested physically active males [103], 13 participants completed 60 sets of 3-second maximum voluntary contractions of the knee extensors, and 16 participants completed two 3-minute all-out tests on a cycle ergometer. The critical torque and critical power were estimated from the mean torque or power output over the last 12 contractions or the final 30 seconds of the test, respectively.…”

Section: Cycling Performancementioning

confidence: 99%

Non-Steroidal Anti-Inflammatory Drug Use in Endurance Sports: Balancing Performance and Health Implications - a Literature Review

Meyer-Glitza,

Langer,

Wieder

2023

Preprint

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The prevailing practice of using non-steroidal anti-inflammatory drugs(NSAIDs) in endurance sports, despite the lack of consistent evidence for theirergogenic effects, raises questions about potential benefits beyond painmanagement and the specific adverse consequences they might entail. Contraryto the intended outcomes, NSAIDs have shown mixed effectiveness in alleviatinginflammation during or after exercise, mainly showing harmful consequences inrunning. These contraproductive effects are particularly concerning for thegastrointestinal system.Regarding muscle adaptation, high doses of NSAIDs have been shown to inhibitmuscle growth, while moderate doses have a minor impact. Although theavailable studies on the impact of NSAIDs on human mitochondrial biogenesisare scarce, in vitro experiments suggest potential negative consequences.Furthermore, the presumed benefits of NSAIDs in promoting healing for softtissue, bone injuries, and muscle damage are frequently undermined, potentiallyimpeding the natural recovery process. Concerns regarding bone healingencompass delayed callus maturation, compromised mechanical strength, and anincreased fracture risk due to the inhibition of osteoblasts.In conclusion, endurance athletes are advised to exercise caution whencontemplating the use of NSAIDs without clear indications, as their potentialadverse effects outweigh the limited advantages in terms of performanceenhancement. While short-term NSAID applications may offer transient relief,alternative strategies should be sought for fostering long-term healing andoptimizing performance.Considering these findings, this review aims to provide endurance athletes withinsights spanning injury management, training adaptation, race performance, andrecovery.

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Acute ibuprofen ingestion does not attenuate fatigue during maximal intermittent knee extensor or all-out cycling exercise

Abstract: Acute ingestion of 400 mg IBP does not improve single-leg or maximal cycling performance in healthy humans.

Cited by 6 publications

References 54 publications

Effect of Non-Steroidal Anti-Inflammatory Drugs on Sport Performance Indices in Healthy People: a Meta-Analysis of Randomized Controlled Trials

Effect of Non-Steroidal Anti-Inflammatory Drugs on Sport Performance Indices in Healthy People: a Meta-Analysis of Randomized Controlled Trials

Greater myofibrillar protein synthesis following weight-bearing activity in obese old compared with non-obese old and young individuals

Non-Steroidal Anti-Inflammatory Drug Use in Endurance Sports: Balancing Performance and Health Implications - a Literature Review

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