Acute idiopathic blind spot enlargement syndrome following measles, mumps and rubella vaccination

Wong, Melody; Campos-Baniak, Maria Gabriela; Colleaux, Kevin

doi:10.1016/j.jcjo.2018.09.005

Cited by 12 publications

(30 citation statements)

References 10 publications

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“… 1 , 3 The examination of patients with AIBSES usually reveals normal fundus and optic disc and, seldom instances, intraocular inflammation. 1 , 3 , 8 , 9 However, as was the case with our patient, some may show mild optic disc swelling and peripapillary vascular changes. 3 , 7 , 8 , 9 …”

Section: Discussionsupporting

confidence: 66%

“… 1 , 3 , 8 , 9 However, as was the case with our patient, some may show mild optic disc swelling and peripapillary vascular changes. 3 , 7 , 8 , 9 …”

Section: Discussionsupporting

confidence: 66%

“…The diagnosis of AIBSES may be challenging or easily missed as the condition lacks explicit changes in the early stages of the disease. 1 , 3 , 8 , 9 In our case, the initial referral was due to suspected optic neuritis due to her complaint of painful eye movements. However, the characteristic visual field defect and OCT findings and normal color vision and negative MRI findings and abnormal mERG suggested otherwise.…”

Section: Discussionmentioning

confidence: 71%

“…As expected, visual field testing in AIBSES shows blind spot enlargement. 1 , 3 , 8 , 9 Furthermore, OCT may reveal loss of regularity of the photoreceptor IS/OS line, and IVFA may show peripapillary leakage. 8 Moreover, mERG tends to be abnormal, more frequently than full-field ERG.…”

Section: Discussionmentioning

confidence: 99%

“…The etiology of AIBSES remains unknown. 3 , 9 There have been numerous case reports of PICCPs following vaccination, including influenza, but to our knowledge, only one case of AIBSES was reported following the measles, mumps, and rubella (MMR) vaccine. 9 , 10 , 11 We report this case of a 57-year-old female with AIBSES after influenza vaccination to highlight vaccination as an important consideration in the medical history for the differential diagnosis of chorioretinal inflammatory syndromes.…”

Section: Introductionmentioning

confidence: 99%

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Acute idiopathic blind spot enlargement syndrome following influenza vaccination

Quinones

Ortíz

Oliver

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To report a case of acute idiopathic blind spot enlargement syndrome (AIBSES) following influenza vaccination. Observations A 57-year old woman presented with a one-month history of photopsia, temporal visual field disturbance on the right eye, 11 days following the administration of the influenza virus vaccine. Visual acuity was 20/30, and color vision remained normal. Examination revealed mild venular dilation at the edge of the right optic disk and was otherwise unremarkable. Visual field testing revealed enlargement of the right physiological blind spot. Medical workup, including brain CT scan, brain MRI, RPR, Treponema pallidum antibodies, Chest X-Ray, ANA, and PPD testing, was found within normal limits. Ancillary testing was compatible with an assessment of AIBSES secondary to influenza virus vaccination. Conclusions and Importance Although direct causation may not be absolutely established by a single report, our case suggests that the influenza virus vaccine may serve as an immunological trigger for some cases of AIBSES. Thoughtful vaccination history is of the utmost importance when evaluating patients with AIBSES, as it may help elucidate the underlying precipitating factor. To our knowledge, this is the first reported case of AIBSES following influenza virus vaccination.

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Section: Discussionsupporting

confidence: 66%

“… 1 , 3 , 8 , 9 However, as was the case with our patient, some may show mild optic disc swelling and peripapillary vascular changes. 3 , 7 , 8 , 9 …”

Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Acute idiopathic blind spot enlargement syndrome following influenza vaccination

Quinones

Ortíz

Oliver

et al. 2020

American Journal of Ophthalmology Case Reports

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The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review

Abu Serhan,

Abu Suilik,

Hassan

et al. 2024

Int Ophthalmol

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Purpose To review all studies reporting the onset of white dot syndromes following COVID-19 vaccines. Methods Our protocol was registered prospectively on PROSPERO [registration number: CRD42023426012]. We searched five different databases including PubMed, Scopus, Web of Science, Google Scholar, and Science Direct up to May 2023. All the studies that reported the occurrence of white dot syndrome following COVID-19 vaccines were included. All statistical tests were conducted with a 95% confidence interval and a 5% error margin. A p value of less than 0.05 was considered statistically significant. The methodological quality of included studies was performed using the IHE Quality Appraisal Checklist for Case Series studies and JBI Critical Appraisal Checklist for Case Reports. Results Fifty studies involving seventy-one subjects were included. Multiple evanescent white dot syndrome (MEWDS) was the most common disease (n = 25, 35.2% %), followed by acute macular neuroretinopathy (AMN) (n = 22, 31.0%) and acute posterior multifocal placoid pigment epitheliopathy (APMPPE) (n = 4, 5.6%). They were mostly unilateral (n = 50, 70.4%). The presenting symptoms were blurred vision (n = 26, 36.6%), paracentral scotoma (n = 19, 26.8%), visual field disturbance, and photopsia (n = 7, 9.9%). The mean duration for follow-up was 10.15 ± 14.04 weeks. Nineteen subjects (29.69%) received steroids with improvement reported in 68.4%. Eleven subjects (17.19%) were managed by observation only with reported full recovery and improvement. Conclusion White dot syndromes are very rare entities. Our findings highlight a possible association between COVID-19 vaccines and the occurrence of white dot syndromes. However, larger studies with good quality should be implemented to confirm these findings.

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Measles-mumps-and-rubella-virus-vaccine

2019

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Acute idiopathic blind spot enlargement syndrome following measles, mumps and rubella vaccination

Cited by 12 publications

References 10 publications

Acute idiopathic blind spot enlargement syndrome following influenza vaccination

Acute idiopathic blind spot enlargement syndrome following influenza vaccination

The characteristics of white dot syndromes following COVID-19 Vaccines: a systematic review

Measles-mumps-and-rubella-virus-vaccine

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