Acute idiopathic thrombocytopenic purpura in children

McWilliams, Nancy B.; Maurer, Harold M.

doi:10.1002/ajh.2830070111

Cited by 45 publications

(10 citation statements)

References 75 publications

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“…The improvement of platelet counts which occurred within 4 wk in about 70% of the children in the untreated group, and in 88% of these children by the end of 4 months, would support the concept that treatment of this disorder in children may not be mandatory if bleeding is not H I~M P a ter oral pred a problem; however, such a prediction is not possible. Our results with oral prednisone coincide with Lusher & Iyer's (9) conclusion, based on a retrospective analysis of 236 children with ITP, although this is contrary to several more recent studies (10)(11)(12). Platelet response in 3 d was observed only in the HIVMP groupas it was in chronic ITP (6,13).…”

Section: Discussionsupporting

confidence: 69%

High‐dose intravenous methylprednisolone for acute childhood idiopathic thrombocytopenic purpura

Özsoylu

İrken

Karabent

1989

European J of Haematology

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49 children with acute idiopathic thrombocytopenic purpura (ITP) were divided into non-treatment, oral prednisone (2 mg/kg), and high-dose intravenous methylprednisolone (HIVMP) treatment groups which consisted of 17, 16 and 16 children respectively. Platelet counts rose above 150000/~1 over a 2-week period in 5 (29.4%) children in the first group, 5 (31.2%) in the second group and 15 (93.7%) children in the third group. Platelet counts reached the normal level in only 3 days in 11 (68.7%) children treated with HIVMP. Initially, antiplatelet antibodies (APA) were shown by the Handin and Stossel method in every patient. With normalization of platelet counts, the antibodies decreased but could still be detected in every case; antibody decrease was greater in the HIVMP group. With the exception of mild cushingoid appearance, none of the major corticosteroid side effects was observed in the treated children.

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Section: Discussionsupporting

confidence: 69%

High‐dose intravenous methylprednisolone for acute childhood idiopathic thrombocytopenic purpura

Özsoylu

İrken

Karabent

1989

European J of Haematology

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“…Although the clinical course may be alarming, mortality is low and prognosis is excellent [35], with 80–90%[11] rates of complete remission, irrespective of treatment. Some authors have recommended adequate parental education, restrictions of lifestyle and in the absence of severe haemorrhages, monitored waiting without specific therapy [25,36,37].…”

Section: Discussionmentioning

confidence: 99%

Dental treatment for children with chronic idiopathic thrombocytopaenic purpura: a report of two cases

Vaisman

Medina

Ramírez

2004

Int J Paed Dentistry

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Idiopathic thrombocytopaenic purpura (ITP) is the most common acquired bleeding disorder occurring in previously healthy children. The condition is benign and self-limiting, with a high possibility of recovery. Only 15-30% of children with acute ITP develop the chronic form. Clinically, ITP presents with petechiae, ecchymoses, haematomas, epistaxis, haematuria, mucocutaneous bleeding, and occasionally, haemorrhage into tissues. Oral manifestations include spontaneous gingival bleeding, petechiae or haematomas of the mucosa, tongue or palate. Two paediatric case reports are described concerning female patients diagnosed with chronic ITP. Oral findings and dental procedures are described. Standard dental treatment was performed with a platelet count higher than 50,000/mm3. The importance of adequate dental plaque control techniques in order to prevent inflammation, potential bleeding and infection in these patients is emphasized. The paediatric dentist must be aware of the clinical appearance of ITP in order to recognize the condition and successfully manage the patient.

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“…It is usually self-limited with spontaneous remissions in 90% of cases [16]. Splenomegaly has been reported in 10% of patients [18]. The duration of disease ranges from few days to weeks with an average of 4-6 weeks [19].…”

Section: Discussionmentioning

confidence: 99%

A Clinical Study of Patients With Idiopathic Thrombocytopenic Purpura

Rao

Patil

et al. 2017

Asian J Pharm Clin Res

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Objective: Idiopathic thrombocytopenic purpura (ITP) is an immuunological disorder characterized by the production of antibodies targeted toward platelets. Corticosteroids and intravenous immunoglobulins were the mainstay of immediate treatment after 1950s with splenectomy for more than 100 years remains the only option with curative potential. The aim of this study was to analyze the incidence, age and sex distribution among adults, various modes of presentation, correlation between thrombocytopenia and bleeding manifestations, and various modalities of treatment of ITP in a tertiary care hospital in India.. Methods:A prospective study included 40 cases of ITP admitted to Kasturba Medical College Hospital, Manipal, from November 2005 to March 2007. Patients above 14 years of age admitted with thrombocytopenia in this institution were screened based on detailed clinical history, physical examination, and laboratory investigations. Results:The maximum incidence was in the 3 rd decade of life accounting for 27.5% of the patients. Male-to-female ratio was 1:1.9 with female preponderance. Females in the 3 rd decade had maximum incidence while males in the 4 th decade have maximum incidence. The majority (12, 85.71%) of male patients and 15 (57.69%) female patients developed purpura during the course of disease. The mean count was 17.8×10 Among the remaining patients, 3 (7.5%) had a relapse of symptoms within next 6 months and responded to repeat prednisolone started at 1 mg/kg. 2 (5%) patients were given steroids tapering dose with IV immune globulins for initial 5 days as therapy to which they responded. Conclusion:Idiopathic thrombocytopenia is 1.9 times more common in females than males. Most common presentation is bleeding spots over body. Bleeding manifestations are more common with thrombocytopenia <30000/mm 3 . Corticosteroids are the mainstay in treatment. Complete remission is seen in up to 57.5% of the patients. Splenectomy is the second modality of treatment in ITP. Complete and sustained remission is seen 75% of patients.

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Acute idiopathic thrombocytopenic purpura in children

Cited by 45 publications

References 75 publications

High‐dose intravenous methylprednisolone for acute childhood idiopathic thrombocytopenic purpura

High‐dose intravenous methylprednisolone for acute childhood idiopathic thrombocytopenic purpura

Dental treatment for children with chronic idiopathic thrombocytopaenic purpura: a report of two cases

A Clinical Study of Patients With Idiopathic Thrombocytopenic Purpura

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