Acute immunomodulatory effects of iron polyisomaltosate in rats

Poljak‐Blaži, Marija; Jaganjac, Morana; Mustapić, Maja; Pivac, Nela; Mück‐Šeler, Dorotea

doi:10.1016/j.imbio.2008.07.005

Cited by 18 publications

(9 citation statements)

References 40 publications

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“…Activation of AP-1 under oxidative conditions is believed to be mediated via phosphorylation of protooncogene c-jun [68]. Metal NP including Cr, Ni, and Fe have been shown to activate AP-1 via ROS generation [60]. …”

Section: Cellular Signaling Affected By Metal Nanoparticlesmentioning

confidence: 99%

“…Apart from industrial scale applications, metal NP are increasingly used in a variety of consumer products such as cosmetics, sunscreens, textiles, and food products. Among the transition metal oxides, titanium dioxide, cupric oxide, and zinc oxide have gained attention owing to their commercial usage [60]. Metal oxide particles can undergo surface modification for better stability and binding to other substrates.…”

Section: Introduction To Transition Metalsmentioning

confidence: 99%

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Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Manke

Wang

Rojanasakul

2013

BioMed Research International

1,299

830

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The rapidly emerging field of nanotechnology has offered innovative discoveries in the medical, industrial, and consumer sectors. The unique physicochemical and electrical properties of engineered nanoparticles (NP) make them highly desirable in a variety of applications. However, these novel properties of NP are fraught with concerns for environmental and occupational exposure. Changes in structural and physicochemical properties of NP can lead to changes in biological activities including ROS generation, one of the most frequently reported NP-associated toxicities. Oxidative stress induced by engineered NP is due to acellular factors such as particle surface, size, composition, and presence of metals, while cellular responses such as mitochondrial respiration, NP-cell interaction, and immune cell activation are responsible for ROS-mediated damage. NP-induced oxidative stress responses are torch bearers for further pathophysiological effects including genotoxicity, inflammation, and fibrosis as demonstrated by activation of associated cell signaling pathways. Since oxidative stress is a key determinant of NP-induced injury, it is necessary to characterize the ROS response resulting from NP. Through physicochemical characterization and understanding of the multiple signaling cascades activated by NP-induced ROS, a systemic toxicity screen with oxidative stress as a predictive model for NP-induced injury can be developed.

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Section: Cellular Signaling Affected By Metal Nanoparticlesmentioning

confidence: 99%

Section: Introduction To Transition Metalsmentioning

confidence: 99%

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Manke

Wang

Rojanasakul

2013

BioMed Research International

1,299

830

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“…The dot‐blot immunostaining method [14] was used to analyse the presence of TGF‐β1, IL‐17, GRO1 and neutrophil elastase in plasma samples. One hundred microlitres of 5% plasma samples diluted in phosphate‐buffered saline (PBS) were spotted onto nitrocellulose membranes (Amersham, UK).…”

Section: Methodsmentioning

confidence: 99%

Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression

Jaganjac

Poljak‐Blaži

Schaur

et al. 2012

Clinical and Experimental Immunology

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SummaryThe involvement of granulocytes in immune response against cancer is not well understood. Depending on the cytokine milieu in which they act and on their oxidative burst, granulocytes may play either an inhibitory or stimulatory role in tumour growth. Unsaturated fatty acids, essential components of cellular membranes and storage lipids, are susceptible to granulocyte-derived reactive oxygen species (ROS). ROS can induce lipid peroxidation (LPO) resulting in the destruction of biomembranes. Thus, murine W256 tumour progressing and tumour regressing animal models were used to study the involvement of plasma inflammatory mediators and oxidative burst of circulating granulocytes in malignant destruction and detrimental tumour growth. The involvement of LPO-derived aldehydes (i.e. acrolein, 4-hydroxy-2-nonenal and malondialdehyde) and myeloperoxidase (MPO) appearance in the granulocyte anti-cancer response were further evaluated. The results obtained revealed a significant increase in neutrophil elastase in animals with regressing tumour. Furthermore, the presence of MPO in tumour microenvironment was accompanied by the formation of acrolein only 5 h after tumour transplantation and its presence increased during tumour regression. Later, at an early stage of tumour regression, the presence of other LPO-derived aldehydes were also observed. The results obtained suggest that elevated neutrophil elastase and initiation of LPO may play an important role in the tumour development leading to tumour regression.

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“…The dot‐blot immunostaining method described by Poljak‐Blazi et al (2009), was used to analyze the presence of acrolein‐Lys adducts in BSA solutions treated by automotive exhaust gases obtained from the plain mineral diesel fuel and the one containing different amounts of Ecodiesel. For dot‐blot analysis 200 μL of collected samples from the absorbed exhaust gases were spotted onto nitrocellulose membranes (Amersham).…”

Section: Methodsmentioning

confidence: 99%

Effects of bioreactive acrolein from automotive exhaust gases on human cells in vitro

Jaganjac

Prah

Čipak

et al. 2011

Environmental Toxicology

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Acrolein is a toxic unsaturated aldehyde and widespread environmental pollutant produced during lipid peroxidation and also by burning of tobacco or liquid fuels. Inhalation or dermal exposure to acrolein could be toxic to organisms. This very reactive aldehyde has a strong affinity for binding to proteins thus forming pathogenic protein-adducts. In the present study we have analyzed formation of bioreactive acrolein-protein adducts in bovine serum albumin solution exposed to exhaust gases of mineral diesel fuel and of mineral diesel fuel supplemented with different amounts of a novel diesel fuel additive denoted Ecodiesel (produced by a genuine procedure of recycling of plant oils used for food preparation). The effects of acrolein-protein adducts were tested on human microvascular endothelial cells and on human osteosarcoma cells that are sensitive to bioactivities of lipid peroxidation products. The results have shown a reduction of the bioreactive acrolein in exhaust gases when mineral diesel was supplemented with 5-20% Ecodiesel. Moreover, acrolein-protein adducts obtained from mineral diesel supplemented with Ecodiesel were less toxic than those obtained from mineral diesel alone. Thus, we assume that supplementing mineral diesel fuel with Ecodiesel would be of benefit for the use of renewable energy, for environment and for human health due to reduced environmental pollution with bioreactive acrolein.

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Acute immunomodulatory effects of iron polyisomaltosate in rats

Cited by 18 publications

References 40 publications

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

Elevated neutrophil elastase and acrolein-protein adducts are associated with W256 regression

Effects of bioreactive acrolein from automotive exhaust gases on human cells in vitro

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