Acute impact of erythromycin and tetracycline on the kinetics of nitrification and organic carbon removal in mixed microbial culture

Katipoglu‐Yazan, Tugce; Pala‐Özkök, İlke; Ubay‐Cokgor, Emine; Orhon, Derin

doi:10.1016/j.biortech.2013.06.121

Cited by 78 publications

(38 citation statements)

References 27 publications

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“…), an observation corroborated by Katipoglu-Yazan et al [103]. When Louvet et al applied the same treatment to a different sludge (Epinal), however, a stimulatory effect was observed.…”

Section: Effects Of Antibiotics On Nitrificationsupporting

confidence: 71%

“…Inhibition is often deemed the most probable effect of antibiotics on nitrification, but this hypothesis is ineffectually supported by the present studies. Among 19 antibiotics and antimicrobials investigated, fewer than half (9) show that the antibiotic or antimicrobial tested inhibited nitrification and the minimum inhibitory concentration (MIC) ranged from 200 μg kg −1 (sulfadimethoxine, SDM) [95] to 200 mg kg −1 (TET) [103]. Based on their low sorption coefficients (Table 3), sulfonamide antibiotics are likely to be the most bioavailable, which may account for the low inhibitory concentration of SDM relative to more sorptive species like CTC and TET.…”

Section: Effects Of Antibiotics On Nitrificationmentioning

confidence: 99%

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Antibiotics and the Terrestrial Nitrogen Cycle: A Review

DeVries

Zhang

2016

Curr Pollution Rep

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The distribution, fate, and effects of human and veterinary antibiotics in the environment have been the subject of intense investigation for nearly two decades. Studies show that the structure and function of microbial communities in soil and sediment are modified by antibiotic exposure but the resulting impact on biogeochemical processes is poorly understood. This review summarizes the most recent data on the present use and physicochemical properties of human and veterinary antibiotics and provides an overview of their occurrence in soil and sediment. This is followed by an examination of the potential effects of antibiotics on microbial nitrogen turnover and methodological approaches to measuring the effects of antibiotics on nitrification and denitrification. Recent studies identified six major classes of antibiotics in soil and sediment, occurring at concentrations between ng·kg −1 and mg·kg −1. Among these, tetracycline and fluorquinolone antibiotics are the most resistant to degradation and leaching and may accumulate to high concentrations (mg·kg ) but their occurrence is also reported more frequently.Only 26 studies were found that investigated the effects of antibiotics on microbial nitrogen cycling. Some antibiotics had no observable effect on nitrogen redox activity in soil and sediment while others appeared to increase or decrease rates of reaction. This lack of consensus could be attributed to a number of different variables including antibiotic dose, method of antibiotic application, variations in the microbial community structure, or method of quantification. We conclude by recommending that future studies adopt a more comprehensive approach to report on changes of the microbial community structure and function as well as the short-and long-term impacts of antibiotics on the accumulation and loss of nitrogen pollutants.

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“…), an observation corroborated by Katipoglu-Yazan et al [103]. When Louvet et al applied the same treatment to a different sludge (Epinal), however, a stimulatory effect was observed.…”

Section: Effects Of Antibiotics On Nitrificationsupporting

confidence: 71%

Section: Effects Of Antibiotics On Nitrificationmentioning

confidence: 99%

Antibiotics and the Terrestrial Nitrogen Cycle: A Review

DeVries

Zhang

2016

Curr Pollution Rep

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“…Tetracycline, (TET), the selected antibiotic for this study, is classified among major protein synthesis blocking agents for bacteria. While a few studies were conducted on the impact of TET on the heterotrophic microbial community under aerobic and anaerobic conditions (Louvet et al, 2010;Cetecioglu et al, 2013), only a recent work reported the inhibitory effects of TET on nitrification kinetics following a first exposure of the microbial community to the antibiotics (Katipoglu-Yazan et al, 2013).…”

mentioning

confidence: 99%

Chronic impact of tetracycline on nitrification kinetics and the activity of enriched nitrifying microbial culture

et al. 2015

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“…To conclude, 14 out of the 16 tested antibiotics inhibited nitrification in the environment at therapeutic levels: sulfadiazine, oxytetracycline, ofloxacin, sulfamethoxazole, erythromycin, ciprofloxacin, gentamicin, colistin, trimethoprim, vancomycin, sulfadimethoxin, enrofloxacin, difloxacin, and tetracycline. The inhibition of such therapeutic antibiotic concentrations could entail severe efficiency loss from 25 % (sulfadiazine, in soils at 100 mg/kg; Kotzerke et al 2008) to the complete inhibition of nitrification (all in WWTP, see the antibiotic mixture of Schmidt et al 2012; tetracycline or erythromycin see in Katipoglu-Yazan et al 2013). Overall, environmental relevant concentrations of fluoroquinolones alone or in mixtures were able to inhibit nitrification rates in environmental samples, but the majority of the studies tested therapeutic levels.…”

Section: Nitrification (13 Studies-16 Antibiotics)mentioning

confidence: 90%

“…The duration of the exposure of colistin used by Bressan et al (2013) on ammonia-oxidizing bacteria was 5 h. Schmidt et al (2012) already stated that Binhibition of cell division or protein biosynthesis may be observed only after test duration of several days.^The importance of incubation time was also shown in the BSubstrate Induced Respiration (SIR)^test of Thiele-Bruhn and Beck (2005); no effect was observed after 4 h, whereas respiration was inhibited by both oxytetracycline and sulfapyridine after 24 h. Short-term experiments that are shorter than the growth rate of the targeted bacteria, therefore, explore the effect of the antibiotic on enzyme activity. Studies regarding short-term effects (Bressan et al 2013;Costanzo et al 2005;Hou et al 2015;Katipoglu-Yazan et al 2013) can be contrasted to long-term effect studies: from days (Ahmad et al 2014;Alighardashi et al 2009;Conkle and White 2012;Fountoulakis et al 2004;Hou et al 2015;Ingvorsen et al 2003;Thiele-Bruhn and Beck 2005;Yamamura et al 2014), weeks (Campos et al 2001;Cui et al 2014;Klaver and Matthews 1994;Kotzerke et al 2008;Kotzerke et al 2011;Lotti et al 2012;Rico et al 2014;Roose-Amsaleg et al 2013;Toth et al 2011;Underwood et al 2011;Wunder et al 2013;Yan et al 2013), months (Fernandez et al 2009;Hansen et al 1992;Näslund et al 2008;Rosendahl et al 2012), to a year (442 days by Schmidt et al 2012). Conducting experiments for extended time periods is difficult because degradable antibiotics, as well as nutrients, can be quickly consumed unless continuously added …”

Section: Duration Of the Experiments: Short-term Versus Long-term Effmentioning

confidence: 97%

Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes

Roose‐Amsaleg

Laverman²

2015

Environ Sci Pollut Res

170

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Antibiotic use in the early 1900 vastly improved human health but at the same time started an arms race of antibiotic resistance. The widespread use of antibiotics has resulted in ubiquitous trace concentrations of many antibiotics in most environments. Little is known about the impact of these antibiotics on microbial processes or "non-target" organisms. This mini-review summarizes our knowledge of the effect of synthetically produced antibiotics on microorganisms involved in biogeochemical cycling. We found only 31 articles that dealt with the effects of antibiotics on such processes in soil, sediment, or freshwater. We compare the processes, antibiotics, concentration range, source, environment, and experimental approach of these studies. Examining the effects of antibiotics on biogeochemical processes should involve environmentally relevant concentrations (instead of therapeutic), chronic exposure (versus acute), and monitoring of the administered antibiotics. Furthermore, the lack of standardized tests hinders generalizations regarding the effects of antibiotics on biogeochemical processes. We investigated the effects of antibiotics on biogeochemical N cycling, specifically nitrification, denitrification, and anammox. We found that environmentally relevant concentrations of fluoroquinolones and sulfonamides could partially inhibit denitrification. So far, the only documented effects of antibiotic inhibitions were at therapeutic doses on anammox activities. The most studied and inhibited was nitrification (25-100 %) mainly at therapeutic doses and rarely environmentally relevant. We recommend that firm conclusions regarding inhibition of antibiotics at environmentally relevant concentrations remain difficult due to the lack of studies testing low concentrations at chronic exposure. There is thus a need to test the effects of these environmental concentrations on biogeochemical processes to further establish the possible effects on ecosystem functioning.

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Acute impact of erythromycin and tetracycline on the kinetics of nitrification and organic carbon removal in mixed microbial culture

Cited by 78 publications

References 27 publications

Antibiotics and the Terrestrial Nitrogen Cycle: A Review

Antibiotics and the Terrestrial Nitrogen Cycle: A Review

Chronic impact of tetracycline on nitrification kinetics and the activity of enriched nitrifying microbial culture

Do antibiotics have environmental side-effects? Impact of synthetic antibiotics on biogeochemical processes

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