Acute infection with Epstein–Barr virus is associated with atherogenic lipid changes

Apostolou, F.; Gazi, Irene F.; Lagos, Konstantinos; Tellis, C.; Tselepis, Alexandros D.; Liberopoulos, Evangelos N.; Elisaf, Moses

doi:10.1016/j.atherosclerosis.2010.06.006

Cited by 51 publications

(60 citation statements)

References 40 publications

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“…Various changes in Lp-PLA 2 activity in response to infection have been reported among different animal species [11] and in human studies [4,7,12,13]. PON1 is an esterase exclusively associated with HDL in plasma which plays an important role in HDL-mediated anti-atherogenic action [14].…”

Section: Introductionmentioning

confidence: 98%

Leptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low‐Density Lipoprotein and Decreased High‐Density Lipoprotein

Gazi¹,

Apostolou²,

Liberopoulos³

et al. 2011

Lipids

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The objective of the present study was to evaluate the effects of acute infection with Leptospira interrogans on lipids, lipoproteins and associated enzymes. Fasting serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), apolipoproteins (apo) A-Ι, B, E, C-II, C-III and lipoprotein (a) [Lp(a)] were determined in patients with Leptospirosis on diagnosis and 4 months after recovery as well as in age- and sex-matched controls. Activities of cholesteryl-ester transfer protein (CETP) and lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) as well as paraoxonase 1 (PON1) hydrolysing activity and levels of cytokines were determined. LDL subclass analysis was performed with Lipoprint LDL System. Eleven patients (10 men, mean age 49.5 ± 8.4 years) and 11 controls were included. TC, HDL-C, LDL-C, apoA-I, apoB and Lp(a) levels were lower at baseline, whereas TG and apoE levels were elevated compared with 4 months later. At baseline, higher levels of cytokines and cholesterol concentration of small dense LDL particles (sdLDL-C) were noticed, whereas LDL particle size was lower compared with follow-up. Activities of plasma Lp-PLA(2) and HDL-associated Lp-PLA(2) were lower at baseline compared with post treatment values, whereas PON1 activity was similar at baseline and 4 months later. 4 months after recovery, the levels of all lipid parameters evaluated did not differ compared with controls, except for HDL-C which remained lower. PON1 activity both at baseline and 4 months later was lower in patients compared with controls. Leptospirosis is associated with atherogenic changes of lipids, lipoproteins and associated enzymes.

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Section: Introductionmentioning

confidence: 98%

Leptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low‐Density Lipoprotein and Decreased High‐Density Lipoprotein

Gazi¹,

Apostolou²,

Liberopoulos³

et al. 2011

Lipids

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“…It was reported that paraoxonase activity may change during inflammatory diseases [7]. Paraoxonase enzyme has a role in pathogenesis of a number of diseases like chronic renal failure, Helicobacter pylori infection, intestinal nematode (Nippostrongylus brasiliensis) infection, human immunodeficiency virus infection, chronic hepatitis B, active pulmonary tuberculosis, acute infection with Epstein-Barr virus, HenochSchö nlein purpura, ovarian cancer, asthma, cardiovascular disease, inflammatory disease such as rheumatoid arthritis, and systemic lupus erythematosus, Behcet's disease, psoriasis [6,[17][18][19][20][21][22][23][24][25][26][27][28]. Reactive oxygen species are produced by activated neutrophils during inflammatory response and they are involved in tissue damage induced by inflammation.…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase and arylesterase activity and total oxidative/anti-oxidative status in patients with chronic adenotonsillitis

Koç

Aksoy

Bilinc

et al. 2011

International Journal of Pediatric Otorhinolaryngology

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“…Such changes can explain the correlation of inflammation and infection with atherogenesis [9]. In addition, response to infection and inflammation increases the amount of oxidized lipids in serum, and induces LDL oxidation in the body.…”

Section: Introductionmentioning

confidence: 99%

“…According to the findings of a study on adult patients, acute EBV infection could change the lipid profile which predisposes patients to atherogenesis [9]. However there is no supportive evidence of these changes among pediatric patients with acute infectious mononucleosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis

Sayyahfar

Lavasani²,

Nateghian

et al. 2017

Infect Chemother

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BackgroundAcute Epstein-Barr virus (EBV) infection could lead to atherogenic lipid profile changes in adults; while there is no evidence about the children with Infectious mononucleosis (IM). The aim of this study was to evaluate the lipid profile of the children in acute phase of mononucleosis and two months after the recovery.Materials and MethodsFrom 2010 through 2012, 36 children with IM aged 1-10 years were enrolled in a prospective cross-sectional study. Fasting serum total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglyceride level were measured during acute phase of the disease and after 2 months of the recovery.ResultsFrom 36 patients enrolled, 25 (69.4%) cases were male and the mean age of the patients was 4.1 ± 2.0 years. The mean of the total cholesterol level in the acute phase and 2 months after the recovery were149.5 ± 35.3 mg/dL and 145.7±30.6, respectively (P = 0.38). However, the serum level of HDL cholesterol in patients after 2 months of recovery was significantly increased (37.9 ± 9.3 mg/dL vs. 28.5 ± 10.6 mg/dL, P <0.001). The mean value of serum LDL cholesterol was significantly reduced, two months after recovery (81.4 ± 19.5 mg/dL, vs. 92.6 ± 28.8 mg/dL, P = 0.009). Furthermore, the serum triglyceride level was significantly reduced after the recovery (108.7 ± 36.9 mg/dL) compared with the acute phase (163.8 ± 114.3 mg/dL) (P = 0.004).ConclusionEBV infection in children could change lipid profile which is partially restored 2 months after the recovery.

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Acute infection with Epstein–Barr virus is associated with atherogenic lipid changes

Cited by 51 publications

References 40 publications

Leptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low‐Density Lipoprotein and Decreased High‐Density Lipoprotein

Leptospirosis is Associated with Markedly Increased Triglycerides and Small Dense Low‐Density Lipoprotein and Decreased High‐Density Lipoprotein

Paraoxonase and arylesterase activity and total oxidative/anti-oxidative status in patients with chronic adenotonsillitis

Evaluation of Lipid Profile Changes in Pediatric Patients with Acute Mononucleosis

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