Acute infectious purpura fulminans caused by group A β-hemolytic Streptococcus: An uncommon organism

Gupta, Divya; Chandrashekar, Laxmisha; Srinivas, Bheemanathi Hanuman; Thappa, Devinder Mohan

doi:10.4103/2229-5178.178093

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“…The literature review first revealed no patients age 10–50 years, in contrast to the young adult patients with TTS and NF. No previous reports verified the bacteriological property or host predisposition [ 21 ]. Shock and coagulopathy was the hallmark of the disease onset, and half of them were previously healthy children.…”

Section: Discussionmentioning

confidence: 99%

Streptococcus pyogenes-purpura fulminans as an invasive form of group A streptococcal infection

Okuzono

Ishimura

Kanno

et al. 2018

Ann Clin Microbiol Antimicrob

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BackgroundStreptococcus pyogenes is an uncommon pathogen of purpura fulminans, and the pathogenesis of S. pyogenes-purpura fulminans remains unclear because of paucity of cases. We reported a pediatric case of S. pyogenes-purpura fulminans with literature review of the disease.Case presentationA 3-year-old boy showed limping, lethargy and acral gangrene within 24 h. A diagnosis of S. pyogenes-purpura fulminans was made for bacterial isolation from throat and peripheral blood. Intensive therapy led to a survival with amputation of the left distal metatarsal bone, and normal development. The isolated M12 carried no mutation of csrS/R or rgg. Thrombophilia or immunodeficiency was excluded.DiscussionTwelve-reported cases (9 pediatric and 3 elderly) of S. pyogenes-purpura fulminans started with shock and coagulopathy. Five patients age < 8 years had no underlying disease and survived. One youngest and two immunocompromised patients died.ConclusionStreptococcus pyogenes-acute infectious purpura fulminans is a distinctive rare form of aggressive GAS infections.

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Section: Discussionmentioning

confidence: 99%